{"id":"dha-pqp-and-pq-starting-on-day-42","safety":{"commonSideEffects":[{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Vomiting"},{"rate":null,"effect":"Abdominal pain"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Hemolysis (with primaquine in G6PD deficiency)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Dihydroartemisinin-piperaquine (DHA-PQP) combines a fast-acting artemisinin derivative with a longer-acting quinoline to eliminate blood-stage parasites, while primaquine (PQ) targets hypnozoites in the liver to prevent relapse in P. vivax and P. ovale malaria. This combination provides both rapid parasite clearance and prevention of recurrent infections.","oneSentence":"DHA-PQP and PQ are antimalarial combination drugs that work by disrupting parasite metabolism and preventing malaria transmission.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:45:51.997Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Plasmodium vivax malaria treatment and relapse prevention"},{"name":"Plasmodium falciparum malaria treatment"}]},"trialDetails":[{"nctId":"NCT03208907","phase":"PHASE3","title":"DHA-PQP vs Chloroquine and Primaquine for Radical Cure of Vivax Malaria in Brazil","status":"COMPLETED","sponsor":"Fundação de Medicina Tropical Dr. Heitor Vieira Dourado","startDate":"2018-07-05","conditions":"Malaria, Vivax, Therapeutics","enrollment":419}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Experimental treatment with no potential synergy"],"phase":"phase_3","status":"active","brandName":"DHA-PQP and PQ starting on Day 42","genericName":"DHA-PQP and PQ starting on Day 42","companyName":"Fundação de Medicina Tropical Dr. Heitor Vieira Dourado","companyId":"funda-o-de-medicina-tropical-dr-heitor-vieira-dourado","modality":"Small molecule","firstApprovalDate":"","aiSummary":"DHA-PQP and PQ are antimalarial combination drugs that work by disrupting parasite metabolism and preventing malaria transmission. Used for Plasmodium vivax malaria treatment and relapse prevention, Plasmodium falciparum malaria treatment.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}