{"id":"dfdba-with-atorvastatin","safety":{"commonSideEffects":[{"rate":null,"effect":"Infection at graft site"},{"rate":null,"effect":"Graft rejection or resorption"},{"rate":null,"effect":"Swelling or edema"}]},"_chembl":{"chemblId":"CHEMBL1487","moleculeType":"Small molecule","molecularWeight":"558.65"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"DFDBA is an allograft material that provides a scaffold for bone formation and contains osteoinductive proteins that stimulate new bone growth. Atorvastatin, a statin, enhances osteoblast differentiation and bone formation while reducing inflammatory markers, synergistically improving bone regeneration outcomes in dental applications.","oneSentence":"DFDBA (demineralized freeze-dried bone allograft) combined with atorvastatin promotes bone regeneration and reduces inflammation in periodontal and dental defects.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T00:31:46.950Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Periodontal bone defects and regeneration"},{"name":"Alveolar bone loss associated with periodontitis"},{"name":"Dental implant site augmentation"}]},"trialDetails":[{"nctId":"NCT03009097","phase":"PHASE4","title":"Atorvastatin as an Adjunct to DFDBA in Intrabony Defects","status":"COMPLETED","sponsor":"Kamineni Institute of Dental Sciences","startDate":"2013-04","conditions":"Chronic Periaortitis, Intrabony Periodontal Defect","enrollment":26}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["atorvastatin gel"],"phase":"marketed","status":"active","brandName":"DFDBA with atorvastatin","genericName":"DFDBA with atorvastatin","companyName":"Kamineni Institute of Dental Sciences","companyId":"kamineni-institute-of-dental-sciences","modality":"Small molecule","firstApprovalDate":"","aiSummary":"DFDBA (demineralized freeze-dried bone allograft) combined with atorvastatin promotes bone regeneration and reduces inflammation in periodontal and dental defects. Used for Periodontal bone defects and regeneration, Alveolar bone loss associated with periodontitis, Dental implant site augmentation.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}