{"id":"dfd06-cream","safety":{"commonSideEffects":[{"rate":null,"effect":"Application site irritation"},{"rate":null,"effect":"Skin atrophy"},{"rate":null,"effect":"Folliculitis"}]},"_chembl":{"chemblId":"CHEMBL2108947","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"DFD06 is a potent topical corticosteroid formulation designed for enhanced skin penetration and efficacy in inflammatory dermatological conditions. It works by binding to glucocorticoid receptors in skin cells, suppressing the production of pro-inflammatory mediators and reducing immune cell infiltration. The cream formulation is optimized for improved bioavailability and therapeutic effect in treating moderate to severe dermatitis and related inflammatory skin disorders.","oneSentence":"DFD06 is a topical corticosteroid cream that reduces inflammation and immune-mediated skin responses by suppressing inflammatory cytokines and T-cell activation in dermatological conditions.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:09:19.739Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Atopic dermatitis (eczema)"},{"name":"Inflammatory dermatitis conditions"}]},"trialDetails":[{"nctId":"NCT03179605","phase":"PHASE2","title":"Assess the Potential for Adrenal Suppression and Systemic Drug Absorption Following Multiple Dosing With DFD-06","status":"TERMINATED","sponsor":"Primus Pharmaceuticals","startDate":"2017-05-02","conditions":"Psoriasis","enrollment":22},{"nctId":"NCT02131324","phase":"PHASE2","title":"DFD06 Cream vs Clobetasol Propionate Cream, 0.05% Hypothalamic- Pituitary-Adrenal (HPA) Axis Suppression Study in Patients With Moderate to Severe Plaque Psoriasis","status":"COMPLETED","sponsor":"Promius Pharma, LLC","startDate":"2014-05-08","conditions":"Psoriasis","enrollment":50},{"nctId":"NCT02445807","phase":"PHASE3","title":"A Study of the Efficacy and Safety of DFD-06 Cream in the Treatment of Moderate to Severe Plaque Psoriasis","status":"COMPLETED","sponsor":"Promius Pharma, LLC","startDate":"2015-12","conditions":"Chronic Stable Plaque Psoriasis","enrollment":265},{"nctId":"NCT02635204","phase":"PHASE3","title":"A Study of the Efficacy and Safety of DFD-06 Cream in the Treatment of Moderate to Severe Plaque Psoriasis","status":"COMPLETED","sponsor":"Promius Pharma, LLC","startDate":"2015-12","conditions":"Psoriasis","enrollment":267}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":21642,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Clobetasol propionate Cream, 0.025%","clobetasol propionate, Impoyz Cream","Clobetasol Propionate 0.025% Cream"],"phase":"phase_3","status":"active","brandName":"DFD06 Cream","genericName":"DFD06 Cream","companyName":"Promius Pharma, LLC","companyId":"promius-pharma-llc","modality":"Small molecule","firstApprovalDate":"","aiSummary":"DFD06 is a topical corticosteroid cream that reduces inflammation and immune-mediated skin responses by suppressing inflammatory cytokines and T-cell activation in dermatological conditions. Used for Atopic dermatitis (eczema), Inflammatory dermatitis conditions.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}