{"id":"dextrothyroxine","rwe":[{"pmid":"16126018","year":"2005","title":"Diet, lifestyle, and nonstatin trials: review of time to benefit.","finding":"","journal":"The American journal of cardiology","studyType":"Clinical Study"},{"pmid":"10090317","year":"1999","title":"A novel resistance to thyroid hormone associated with a new mutation (T329N) in the thyroid hormone receptor beta gene.","finding":"","journal":"Thyroid : official journal of the American Thyroid Association","studyType":"Clinical Study"},{"pmid":"9440092","year":"1998","title":"D-thyroxine reduces lipoprotein(a) serum concentration in dialysis patients.","finding":"","journal":"Journal of the American Society of Nephrology : JASN","studyType":"Clinical Study"},{"pmid":"7503765","year":"1995","title":"Thyronines and probucol inhibition of human capillary endothelial cell-induced low density lipoprotein oxidation.","finding":"","journal":"Biochemical pharmacology","studyType":"Clinical Study"},{"pmid":"1525565","year":"1992","title":"Dextrothyroxine in the treatment of generalized thyroid hormone resistance in a boy homozygous for a defect in the T3 receptor.","finding":"","journal":"Thyroid : official journal of the American Thyroid Association","studyType":"Clinical Study"}],"tags":[{"label":"dextrothyroxine","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Thyroid hormone receptor","category":"target"},{"label":"THRA","category":"gene"},{"label":"THRB","category":"gene"},{"label":"C10AX01","category":"atc"},{"label":"Off-Patent","category":"patent"},{"label":"Active","category":"status"},{"label":"Hyperlipidemia","category":"indication"},{"label":"Abbvie","category":"company"},{"label":"Approved 1960s","category":"decade"}],"phase":"marketed","safety":{},"trials":[],"aliases":[],"company":"AbbVie","patents":[],"pricing":[],"_sources":{"trials":{"url":"https://clinicaltrials.gov/search?intr=DEXTROTHYROXINE","method":"api_direct","source":"ClinicalTrials.gov","rawText":"","confidence":1,"sourceType":"ctgov","retrievedAt":"2026-04-20T00:49:13.675868+00:00"},"regulatory.ca":{"url":"","method":"api_direct","source":"Health Canada DPD","rawText":"","confidence":1,"sourceType":"health_canada_dpd","retrievedAt":"2026-04-20T00:49:19.023786+00:00"},"publicationCount":{"url":"https://pubmed.ncbi.nlm.nih.gov/?term=DEXTROTHYROXINE","method":"api_direct","source":"PubMed/NCBI","rawText":"","confidence":1,"sourceType":"pubmed","retrievedAt":"2026-04-20T00:49:19.350394+00:00"},"mechanism.target_chembl":{"url":"","method":"api_direct","source":"ChEMBL mechanism: Thyroid hormone receptor agonist","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T00:49:20.402416+00:00"},"crossReferences.chemblId":{"url":"https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL3545058/","method":"api_direct","source":"ChEMBL (EMBL-EBI)","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T00:49:20.071162+00:00"}},"allNames":"choloxin","offLabel":[],"synonyms":["sodium dextrothyroxine","D-Thyroxine","choloxin","dextrothyroxine","dextrothyroxine sodium"],"timeline":[{"date":"1967-04-14","type":"positive","source":"DrugCentral","milestone":"FDA approval (Abbvie)"}],"aiSummary":"Choloxin (Dextrothroxine) is a small molecule drug developed by AbbVie that targets the thyroid hormone receptor. It was approved by the FDA in 1967 for the treatment of hyperlipidemia. As an off-patent medication with no active Orange Book patents, Choloxin is available in its branded form only. Key safety considerations include its potential effects on thyroid function and lipid profiles. Choloxin's commercial status and availability may be subject to regional regulations.","approvals":[{"date":"1967-04-14","orphan":false,"company":"ABBVIE","regulator":"FDA"}],"brandName":"Choloxin","ecosystem":[{"indication":"Hyperlipidemia","otherDrugs":[{"name":"cholestyramine","slug":"cholestyramine","company":"Bristol Myers"},{"name":"choline fenofibrate","slug":"choline-fenofibrate","company":"Abbvie"},{"name":"clofibrate","slug":"clofibrate","company":""},{"name":"colestipol","slug":"colestipol","company":"Pharmacia And Upjohn"}],"globalPrevalence":390000000}],"mechanism":{"target":"Thyroid hormone receptor","novelty":"Follow-on","targets":[{"gene":"THRA","source":"DrugCentral","target":"Thyroid hormone receptor","protein":"Thyroid hormone receptor alpha"},{"gene":"THRB","source":"DrugCentral","target":"Thyroid hormone receptor","protein":"Thyroid hormone receptor beta"}],"modality":"Small Molecule","drugClass":"dextrothyroxine","explanation":"","oneSentence":"","technicalDetail":"Choloxin (Dextrothroxine) is a synthetic analog of thyroxine that selectively binds to thyroid hormone receptors, modulating lipid metabolism and influencing the expression of genes involved in cholesterol homeostasis."},"commercial":{"launchDate":"1967","_launchSource":"DrugCentral (FDA 1967-04-14, 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