{"id":"dextromoramide","rwe":[{"pmid":"37464572","year":"2024","title":"Investigations on the in vitro and in vivo metabolic fate of the new synthetic opioid desmethylmoramide using HPLC-HRMS/MS for toxicological screening purposes.","finding":"","journal":"Drug testing and analysis","studyType":"Clinical Study"},{"pmid":"28681613","year":"2018","title":"The toxicological significance of post-mortem drug concentrations in bile.","finding":"","journal":"Clinical toxicology (Philadelphia, Pa.)","studyType":"Clinical Study"},{"pmid":"25972091","year":"2015","title":"Opioids for agitation in dementia.","finding":"","journal":"The Cochrane database of systematic reviews","studyType":"Clinical Study"},{"pmid":"17943808","year":"2007","title":"Methadone for cancer pain.","finding":"","journal":"The Cochrane database of systematic reviews","studyType":"Clinical Study"},{"pmid":"16966202","year":"2006","title":"Zolpidem and dextromoramide abuse with increased metabolism.","finding":"","journal":"The American journal on addictions","studyType":"Clinical Study"}],"tags":[{"label":"dextromoramide","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"N02AC01","category":"atc"},{"label":"Active","category":"status"},{"label":"Severe pain","category":"indication"},{"label":"Analgesics","category":"pharmacology"},{"label":"Analgesics, Opioid","category":"pharmacology"},{"label":"Central Nervous System Agents","category":"pharmacology"},{"label":"Central Nervous System Depressants","category":"pharmacology"},{"label":"Narcotics","category":"pharmacology"},{"label":"Peripheral Nervous System Agents","category":"pharmacology"},{"label":"Sensory System Agents","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"moramide","offLabel":[],"synonyms":["dextromoramide","moramide","pyrrolamidol","pyrrolamidolum","dextromoramide tartrate"],"timeline":[],"approvals":[],"brandName":"Moramide","ecosystem":[{"indication":"Severe pain","otherDrugs":[{"name":"buprenorphine","slug":"buprenorphine","company":"Reckitt Benckiser"},{"name":"clonidine","slug":"clonidine","company":"Boehringer Ingelheim"},{"name":"hydromorphone","slug":"hydromorphone","company":"Purdue Pharm Prods"},{"name":"ibuprofen","slug":"ibuprofen","company":""}],"globalPrevalence":1500000000}],"mechanism":{"modality":"Small Molecule","drugClass":"dextromoramide","explanation":"Imagine your body has special locks called opioid receptors. Dextromoramide is a key that fits into these locks, which helps to block pain signals to the brain and release feel-good chemicals called endorphins. This can provide relief from severe pain, but it can also lead to dependence and other side effects.","oneSentence":"Dextromoramide works by binding to opioid receptors in the brain, spinal cord, and other areas to produce analgesia and euphoria.","technicalDetail":"Dextromoramide exerts its effects by binding to mu-opioid receptors, kappa-opioid receptors, and delta-opioid receptors, which are involved in pain modulation, reward, and other physiological processes."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/843","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=DEXTROMORAMIDE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T10:32:32.793013","biosimilars":[],"competitors":[{"drugName":"dextropropoxyphene","drugSlug":"dextropropoxyphene","fdaApproval":"1957-08-16","relationship":"same-class"},{"drugName":"methadone","drugSlug":"methadone","fdaApproval":"1947-08-13","genericCount":13,"patentStatus":"Off-patent — generic available","relationship":"same-class"}],"genericName":"dextromoramide","indications":{"approved":[{"name":"Severe pain","source":"DrugCentral","snomedId":76948002,"regulator":"FDA","usPrevalence":51600000,"globalPrevalence":1500000000,"prevalenceMethod":"curated","prevalenceSource":"CDC, 2023"}],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"dextropropoxyphene","brandName":"dextropropoxyphene","genericName":"dextropropoxyphene","approvalYear":"1957","relationship":"same-class"},{"drugId":"methadone","brandName":"methadone","genericName":"methadone","approvalYear":"1947","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NUI":"N0000167041","NDDF":"003694","UNII":"9S4S6CIY83","CHEBI":"CHEBI:74274","INN_ID":"733","RXNORM":"104959","UMLSCUI":"C0011817","ChEMBL_ID":"CHEMBL431928","KEGG_DRUG":"D07287","DRUGBANK_ID":"DB01529","PUBCHEM_CID":"92943","SNOMEDCT_US":"322508000","SECONDARY_CAS_RN":"2922-44-3","MESH_DESCRIPTOR_UI":"D003916"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"pharmacokinetics":{"source":"DrugCentral","halfLife":"3.18 hours","clearance":"2.19 mL/min/kg","bioavailability":"99%","volumeOfDistribution":"0.47 L/kg"},"publicationCount":215,"therapeuticAreas":["Pain"],"atcClassification":{"source":"DrugCentral","atcCode":"N02AC01","allCodes":["N02AC01"]},"biosimilarFilings":[],"recentPublications":[{"date":"2024 Mar","pmid":"37464572","title":"Investigations on the in vitro and in vivo metabolic fate of the new synthetic opioid desmethylmoramide using HPLC-HRMS/MS for toxicological screening purposes.","journal":"Drug testing and analysis"},{"date":"2018 Jan","pmid":"28681613","title":"The toxicological significance of post-mortem drug concentrations in bile.","journal":"Clinical toxicology (Philadelphia, Pa.)"},{"date":"2015 May 14","pmid":"25972091","title":"Opioids for agitation in dementia.","journal":"The Cochrane database of systematic reviews"},{"date":"2007 Oct 17","pmid":"17943808","title":"Methadone for cancer pain.","journal":"The Cochrane database of systematic reviews"},{"date":"2006 Sep-Oct","pmid":"16966202","title":"Zolpidem and dextromoramide abuse with increased metabolism.","journal":"The American journal on addictions"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Moramide is a small molecule that acts as an agonist to the opioid receptors, specifically targeting the mu, kappa, and delta subtypes. It is classified as an agonist within the opioid receptor modality.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":false,"score":2}}