{"id":"dextromethorphan-memantine","safety":{"commonSideEffects":[{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Cognitive effects"}]},"_chembl":{"chemblId":"CHEMBL807","moleculeType":"Small molecule","molecularWeight":"179.31"},"_dailymed":null,"mechanism":{"_ai_source":"anthropic-haiku","explanation":"Memantine is a non-competitive NMDA receptor antagonist that reduces excitotoxicity and neuroinflammation. Dextromethorphan, a sigma-1 receptor agonist and NMDA antagonist, enhances neuroprotection and has analgesic properties. Together, they provide complementary NMDA antagonism and neuroprotective effects, potentially beneficial in neurodegenerative or neuropathic conditions.","oneSentence":"This combination blocks NMDA receptors (memantine) and inhibits reuptake of norepinephrine and serotonin (dextromethorphan) to modulate neuropathic pain and neurological symptoms.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T01:09:18.771Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Neuropathic pain or neurological disorders (specific indication not publicly detailed)"}]},"trialDetails":[{"nctId":"NCT04687566","phase":"PHASE2, PHASE3","title":"Dextromethorphan, Memantine Monotherapy, or Combined Use of Dextromethorphan and Memantine in Amphetamine Addiction","status":"UNKNOWN","sponsor":"National Cheng-Kung University Hospital","startDate":"2020-08-11","conditions":"Amphetamine Addiction, Pharmacotherapy","enrollment":120},{"nctId":"NCT03729128","phase":"PHASE1, PHASE2","title":"Add-on Low Dose Dextromethorphan and Memantine in Patients With Amphetamine-type Stimulants Use Disorder","status":"COMPLETED","sponsor":"Tzu-Yun Wang","startDate":"2018-07-24","conditions":"Stimulants Use Disorder","enrollment":85},{"nctId":"NCT01602185","phase":"PHASE2","title":"Study of NMDA Antagonists and Neuropathic Pain","status":"COMPLETED","sponsor":"University Hospital, Clermont-Ferrand","startDate":"2012-05","conditions":"Neuropathic Pain","enrollment":7},{"nctId":"NCT03039842","phase":"PHASE3","title":"Combination of Dextromethorphan and Memantine in Treating Bipolar Disorder","status":"UNKNOWN","sponsor":"National Cheng-Kung University Hospital","startDate":"2013-01-01","conditions":"Bipolar Disorder II","enrollment":300},{"nctId":"NCT02860338","phase":"","title":"COMPARATIVE EFFECTIVENESS OF MCI and DEMENTIA TREATMENTS IN A COMMUNITY-BASED DEMENTIA PRACTICE","status":"COMPLETED","sponsor":"Clionsky Neuro Systems Inc.","startDate":"2009-01","conditions":"Mild Cognitive Impairment, Dementia, Hypoxia","enrollment":900},{"nctId":"NCT00001344","phase":"PHASE2","title":"Dextromethorphan Versus Placebo for Neuropathic Pain","status":"COMPLETED","sponsor":"National Institute of Dental and Craniofacial Research (NIDCR)","startDate":"1993-03","conditions":"Diabetic Neuropathies, Herpes Zoster, Neuralgia","enrollment":129}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"dextromethorphan+memantine","genericName":"dextromethorphan+memantine","companyName":"National Cheng-Kung University Hospital","companyId":"national-cheng-kung-university-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This combination blocks NMDA receptors (memantine) and inhibits reuptake of norepinephrine and serotonin (dextromethorphan) to modulate neuropathic pain and neurological symptoms. Used for Neuropathic pain or neurological disorders (specific indication not publicly detailed).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}