{"id":"dexter-ketamine","safety":{"commonSideEffects":[{"rate":null,"effect":"Dissociation"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Sedation"},{"rate":null,"effect":"Increased blood pressure"}]},"_chembl":{"chemblId":"CHEMBL742","moleculeType":"Small molecule","molecularWeight":"237.73"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Dexketamine is the S(+)-enantiomer of ketamine, which acts as a non-competitive antagonist at the N-methyl-D-aspartate (NMDA) receptor. This mechanism differs from traditional monoamine-based antidepressants and produces faster onset of action. The drug is used clinically for treatment-resistant depression and has anesthetic properties.","oneSentence":"Dexketamine (the active S-enantiomer of ketamine) blocks NMDA glutamate receptors in the central nervous system to produce rapid-acting antidepressant and anesthetic effects.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:44:31.813Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Treatment-resistant depression"},{"name":"Anesthesia induction and maintenance"}]},"trialDetails":[{"nctId":"NCT02953210","phase":"PHASE4","title":"Laparoscopic Cholecystectomy: General Anesthesia With Opioid Versus General Opioid Free Anesthesia","status":"UNKNOWN","sponsor":"Federal University of São Paulo","startDate":"2016-11","conditions":"Pain, Postoperative, Anesthesia Complication, Nausea","enrollment":40}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["ketamine plus"],"phase":"marketed","status":"active","brandName":"dexter ketamine","genericName":"dexter ketamine","companyName":"Federal University of São Paulo","companyId":"federal-university-of-s-o-paulo","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Dexketamine (the active S-enantiomer of ketamine) blocks NMDA glutamate receptors in the central nervous system to produce rapid-acting antidepressant and anesthetic effects. Used for Treatment-resistant depression, Anesthesia induction and maintenance.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}