{"id":"dextenza-ophthalmic-insert","safety":{"commonSideEffects":[{"rate":null,"effect":"Ocular irritation"},{"rate":null,"effect":"Conjunctival hyperemia"},{"rate":null,"effect":"Eye discomfort"},{"rate":null,"effect":"Increased intraocular pressure"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Dextenza is a sustained-release insert placed in the canaliculus (tear drainage system) that provides prolonged local delivery of dexamethasone, a potent corticosteroid. The insert gradually releases the drug over several days, maintaining therapeutic concentrations in the anterior segment of the eye while minimizing systemic exposure. This localized delivery reduces post-operative inflammation, pain, and the need for frequent topical eye drops.","oneSentence":"Dextenza is a corticosteroid-eluting ophthalmic insert that delivers dexamethasone directly to ocular tissues to reduce inflammation and pain following eye surgery.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:09:22.140Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Post-operative inflammation and pain following ocular surgery"},{"name":"Corneal refractive surgery pain and inflammation"}]},"trialDetails":[{"nctId":"NCT06235567","phase":"PHASE1, PHASE2","title":"Dextenza Versus Topical Steroid Eye Drops for Postoperative Management Following Corneal Crosslinking","status":"ENROLLING_BY_INVITATION","sponsor":"Maanasa Indaram, MD","startDate":"2025-04-11","conditions":"Keratoconus","enrollment":20},{"nctId":"NCT04977427","phase":"PHASE4","title":"Dextenza vs Prednisolone Acetate After Cataract Surgery for Patients With Diabetes","status":"WITHDRAWN","sponsor":"Baylor Research Institute","startDate":"2021-08-31","conditions":"Cataract Diabetic, Macula Edema","enrollment":""},{"nctId":"NCT05626478","phase":"PHASE4","title":"Assessing eFficacy and Safety of DEXTENZA 0.4 mg inseRt, Following Cataract Surgery","status":"COMPLETED","sponsor":"Nicole Fram M.D.","startDate":"2023-06-01","conditions":"Corneal Edema, Corneal Defect, Anterior Chamber Inflammation","enrollment":50},{"nctId":"NCT04371445","phase":"PHASE4","title":"Dextenza in the Post-op Management of Vitreoretinal Surgeries","status":"RECRUITING","sponsor":"The Cleveland Clinic","startDate":"2020-06-01","conditions":"Vitreoretinal Surgery, Ocular Inflammation, Post-operative Pain","enrollment":30},{"nctId":"NCT05620901","phase":"EARLY_PHASE1","title":"DEXTENZA in Pediatric Patients Following Retinal Surgery or Laser Treatment Under Anesthesia","status":"COMPLETED","sponsor":"Lejla Vajzovic, MD, FASRS","startDate":"2023-02-01","conditions":"Vitreoretinopathy, Coats' Disease, Exudative Retinopathy","enrollment":16},{"nctId":"NCT05023304","phase":"PHASE4","title":"In Clinic Optometrist Insertion of Dextenza Prior to Cataract Surgery","status":"COMPLETED","sponsor":"Vance Thompson Vision","startDate":"2021-08-23","conditions":"Cataract","enrollment":30},{"nctId":"NCT04418999","phase":"EARLY_PHASE1","title":"Safety and Efficacy of Intracanalicular Dexamethasone Compared to Loteprednol Etabonate in Patients With Keratoconus","status":"COMPLETED","sponsor":"Illinois College of Optometry","startDate":"2020-09-01","conditions":"Keratoconus, Dry Eye, Allergy","enrollment":36},{"nctId":"NCT04527887","phase":"PHASE4","title":"Intracanalicular Dexamethasone Insert for the Treatment of Inflammation and Discomfort in Dry Eye Disease (DEcIDED)","status":"TERMINATED","sponsor":"Tufts Medical Center","startDate":"2020-09-04","conditions":"Dry Eye","enrollment":54},{"nctId":"NCT04237012","phase":"PHASE4","title":"ACCURATE Study for Subjects With Dry Eyes","status":"COMPLETED","sponsor":"The Eye Centers of Racine and Kenosha","startDate":"2019-12-16","conditions":"Dry Eye Syndromes","enrollment":30},{"nctId":"NCT04667507","phase":"PHASE4","title":"Pharmacokinetics of Aqueous Dexamethasone","status":"COMPLETED","sponsor":"Frank A. 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