{"id":"dexrabeprazole","rwe":[{"pmid":"37699222","year":"2023","title":"Reply to the letter to the editor \"Clarifications on the safety of dexrabeprazole vs. omeprazole in the treatment of gastroesophageal reflux disease\".","finding":"","journal":"Gaceta medica de Mexico","studyType":"Clinical Study"},{"pmid":"37699220","year":"2023","title":"Clarifications on the safety of dexrabeprazole vs. omeprazole in the treatment of gastroesophageal reflux disease.","finding":"","journal":"Gaceta medica de Mexico","studyType":"Clinical Study"},{"pmid":"36657136","year":"2022","title":"Efficacy and safety comparative study of dexrabeprazole vs. esomeprazole for the treatment of gastroesophageal reflux disease.","finding":"","journal":"Gaceta medica de Mexico","studyType":"Clinical Study"},{"pmid":"32312104","year":"2021","title":"Determination of Proton Pump Inhibitors by Spectrophotometric, Chromatographic and by Hyphenated Techniques: A Review.","finding":"","journal":"Critical reviews in analytical chemistry","studyType":"Clinical Study"},{"pmid":"31281995","year":"2019","title":"Chiral separation of lansoprazole and rabeprazole by capillary electrophoresis using dual cyclodextrin systems.","finding":"","journal":"Electrophoresis","studyType":"Clinical Study"}],"tags":[{"label":"Proton Pump Inhibitors","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Proto-oncogene tyrosine-protein kinase receptor Ret","category":"target"},{"label":"RET","category":"gene"},{"label":"FLT1","category":"gene"},{"label":"FLT4","category":"gene"},{"label":"A02BC07","category":"atc"},{"label":"Active","category":"status"},{"label":"Duodenal Ulcer due to H. Pylori","category":"indication"},{"label":"Duodenal ulcer disease","category":"indication"},{"label":"Erosive esophagitis","category":"indication"},{"label":"Gastric Hypersecretory Conditions","category":"indication"},{"label":"Gastric ulcer","category":"indication"},{"label":"Gastroesophageal reflux disease","category":"indication"},{"label":"Anti-Ulcer Agents","category":"pharmacology"},{"label":"Enzyme Inhibitors","category":"pharmacology"},{"label":"Gastrointestinal Agents","category":"pharmacology"},{"label":"Proton Pump Inhibitors","category":"pharmacology"}],"phase":"unknown","safety":{"drugInteractions":[{"url":"/drug/clopidogrel","drug":"clopidogrel","action":"Avoid combination","effect":"esomeprazole may diminish the antiplatelet effect of clopidogrel","source":"DrugCentral","drugSlug":"clopidogrel"},{"url":"/drug/dasatinib","drug":"dasatinib","action":"Avoid combination","effect":"Proton Pump Inhibitors may decrease the serum concentration of Dasatinib","source":"DrugCentral","drugSlug":"dasatinib"},{"url":"/drug/delavirdine","drug":"delavirdine","action":"Avoid combination","effect":"Proton Pump Inhibitors may decrease the serum concentration of Delavirdine","source":"DrugCentral","drugSlug":"delavirdine"},{"url":"/drug/erlotinib","drug":"erlotinib","action":"Avoid combination","effect":"Proton Pump Inhibitors may decrease the serum concentration of Erlotinib","source":"DrugCentral","drugSlug":"erlotinib"},{"url":"/drug/nelfinavir","drug":"nelfinavir","action":"Avoid combination","effect":"Proton Pump Inhibitors may decrease serum concentrations of the active metabolite(s) of Nelfinavir","source":"DrugCentral","drugSlug":"nelfinavir"},{"url":"/drug/ponatinib","drug":"ponatinib","action":"Avoid combination","effect":"Proton Pump Inhibitors may decrease the serum concentration of Ponatinib","source":"DrugCentral","drugSlug":"ponatinib"},{"url":"/drug/rilpivirine","drug":"rilpivirine","action":"Avoid combination","effect":"Proton Pump Inhibitors may decrease the serum concentration of Rilpivirine","source":"DrugCentral","drugSlug":"rilpivirine"},{"url":"/drug/risedronic-acid","drug":"risedronic acid","action":"Avoid combination","effect":"Proton Pump Inhibitors may diminish the therapeutic effect of Risedronate","source":"DrugCentral","drugSlug":"risedronic-acid"}],"contraindications":["Acute nephropathy","Atrophic gastritis","Chronic heart failure","Disease of liver","Edema","Fracture of bone","Hepatic failure","Hypomagnesemia","Oliguria","Osteoporosis"]},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"dexpure","offLabel":[],"synonyms":["E3810","dexrabeprazole","dexrabeprazole sodium","dexpure"],"timeline":[],"approvals":[],"brandName":"Dexpure","ecosystem":[{"indication":"Duodenal Ulcer due to H. Pylori","otherDrugs":[{"name":"amoxicillin","slug":"amoxicillin","company":"Apothecon"},{"name":"bismuth subcitrate","slug":"bismuth-subcitrate","company":""},{"name":"bismuth subsalicylate","slug":"bismuth-subsalicylate","company":"Prometheus Labs"},{"name":"clarithromycin","slug":"clarithromycin","company":"Abbvie"}],"globalPrevalence":null},{"indication":"Duodenal ulcer disease","otherDrugs":[{"name":"algeldrate","slug":"algeldrate","company":"Sanofi Aventis Us"},{"name":"cimetidine","slug":"cimetidine","company":""},{"name":"famotidine","slug":"famotidine","company":"Valeant Pharms North"},{"name":"lansoprazole","slug":"lansoprazole","company":"Takeda Pharms Usa"}],"globalPrevalence":null},{"indication":"Erosive esophagitis","otherDrugs":[{"name":"dexlansoprazole","slug":"dexlansoprazole","company":"Takeda Pharms Usa"},{"name":"esomeprazole","slug":"esomeprazole","company":"Astrazeneca Pharms"},{"name":"famotidine","slug":"famotidine","company":"Valeant Pharms North"},{"name":"lansoprazole","slug":"lansoprazole","company":"Takeda Pharms Usa"}],"globalPrevalence":null},{"indication":"Gastric Hypersecretory Conditions","otherDrugs":[{"name":"algeldrate","slug":"algeldrate","company":"Sanofi Aventis Us"},{"name":"almasilate","slug":"almasilate","company":""},{"name":"lansoprazole","slug":"lansoprazole","company":"Takeda Pharms Usa"},{"name":"magnesium carbonate","slug":"magnesium-carbonate","company":"United Guardian"}],"globalPrevalence":null},{"indication":"Gastric ulcer","otherDrugs":[{"name":"algeldrate","slug":"algeldrate","company":"Sanofi Aventis Us"},{"name":"cimetidine","slug":"cimetidine","company":""},{"name":"famotidine","slug":"famotidine","company":"Valeant Pharms North"},{"name":"lansoprazole","slug":"lansoprazole","company":"Takeda Pharms Usa"}],"globalPrevalence":null},{"indication":"Gastroesophageal reflux disease","otherDrugs":[{"name":"algeldrate","slug":"algeldrate","company":"Sanofi Aventis Us"},{"name":"almasilate","slug":"almasilate","company":""},{"name":"cimetidine","slug":"cimetidine","company":""},{"name":"cisapride","slug":"cisapride","company":""}],"globalPrevalence":null},{"indication":"Maintenance of Healing Erosive Esophagitis","otherDrugs":[{"name":"dexlansoprazole","slug":"dexlansoprazole","company":"Takeda Pharms Usa"},{"name":"esomeprazole","slug":"esomeprazole","company":"Astrazeneca Pharms"},{"name":"omeprazole","slug":"omeprazole","company":"Astrazeneca Pharms"},{"name":"pantoprazole","slug":"pantoprazole","company":"Wyeth Pharms Inc"}],"globalPrevalence":null},{"indication":"Pathological Gastric Hypersecretory Condition","otherDrugs":[{"name":"esomeprazole","slug":"esomeprazole","company":"Astrazeneca Pharms"},{"name":"omeprazole","slug":"omeprazole","company":"Astrazeneca Pharms"},{"name":"rabeprazole","slug":"rabeprazole","company":"Eisai Inc"}],"globalPrevalence":null}],"mechanism":{"target":"Proto-oncogene tyrosine-protein kinase receptor Ret","targets":[{"gene":"RET","source":"DrugCentral","target":"Proto-oncogene tyrosine-protein kinase receptor Ret","protein":"Proto-oncogene tyrosine-protein kinase receptor Ret"},{"gene":"FLT1","source":"DrugCentral","target":"Vascular endothelial growth factor receptor 1","protein":"Vascular endothelial growth factor receptor 1"},{"gene":"FLT4","source":"DrugCentral","target":"Vascular endothelial growth factor receptor 3","protein":"Vascular endothelial growth factor receptor 3"},{"gene":"DDR1","source":"DrugCentral","target":"Epithelial discoidin domain-containing receptor 1","protein":"Epithelial discoidin domain-containing receptor 1"},{"gene":"FGFR1","source":"DrugCentral","target":"Fibroblast growth factor receptor 1","protein":"Fibroblast growth factor receptor 1"},{"gene":"KDR","source":"DrugCentral","target":"Vascular endothelial growth factor receptor 2","protein":"Vascular endothelial growth factor receptor 2"},{"gene":"FGFR2","source":"DrugCentral","target":"Fibroblast growth factor receptor 2","protein":"Fibroblast growth factor receptor 2"},{"gene":"DDR2","source":"DrugCentral","target":"Discoidin domain-containing receptor 2","protein":"Discoidin domain-containing receptor 2"},{"gene":"RIPK2","source":"DrugCentral","target":"Receptor-interacting serine/threonine-protein kinase 2","protein":"Receptor-interacting serine/threonine-protein kinase 2"},{"gene":"FGFR3","source":"DrugCentral","target":"Fibroblast growth factor receptor 3","protein":"Fibroblast growth factor receptor 3"}],"modality":"Small Molecule","drugClass":"Proton Pump Inhibitors","explanation":"Imagine your stomach lining is like a factory that produces acid to help digest food. Dexpure blocks the acid-producing factories, reducing the amount of acid produced and helping to heal stomach ulcers and other conditions.","oneSentence":"Dexpure works by irreversibly inhibiting the H+/K+ ATPase enzyme in the stomach lining, reducing acid production.","technicalDetail":"Dexpure is a competitive and reversible inhibitor of the H+/K+ ATPase enzyme, specifically targeting the proton pump in the gastric parietal cells, which is responsible for acid secretion."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/4867","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=dexrabeprazole","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=dexrabeprazole","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T10:37:41.779054","biosimilars":[],"competitors":[{"drugName":"omeprazole","drugSlug":"omeprazole","fdaApproval":"1989-09-14","patentExpiry":"Dec 8, 2036","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"pantoprazole","drugSlug":"pantoprazole","fdaApproval":"2000-02-02","patentExpiry":"Jun 7, 2026","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"lansoprazole","drugSlug":"lansoprazole","fdaApproval":"1995-05-10","patentExpiry":"Apr 21, 2036","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"rabeprazole","drugSlug":"rabeprazole","fdaApproval":"1999-08-19","genericCount":10,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"esomeprazole","drugSlug":"esomeprazole","fdaApproval":"2001-02-20","patentExpiry":"Dec 8, 2036","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"dexlansoprazole","drugSlug":"dexlansoprazole","fdaApproval":"2009-01-30","patentExpiry":"Sep 27, 2026","patentStatus":"Patent protected","relationship":"same-class"}],"genericName":"dexrabeprazole","indications":{"approved":[{"name":"Duodenal Ulcer due to H. Pylori","source":"DrugCentral","snomedId":"","regulator":"FDA"},{"name":"Duodenal ulcer disease","source":"DrugCentral","snomedId":51868009,"regulator":"FDA"},{"name":"Erosive esophagitis","source":"DrugCentral","snomedId":40719004,"regulator":"FDA"},{"name":"Gastric Hypersecretory Conditions","source":"DrugCentral","snomedId":"","regulator":"FDA"},{"name":"Gastric ulcer","source":"DrugCentral","snomedId":397825006,"regulator":"FDA"},{"name":"Gastroesophageal reflux disease","source":"DrugCentral","snomedId":235595009,"regulator":"FDA"},{"name":"Maintenance of Healing Erosive Esophagitis","source":"DrugCentral","snomedId":"","regulator":"FDA"},{"name":"Pathological Gastric Hypersecretory Condition","source":"DrugCentral","snomedId":"","regulator":"FDA"},{"name":"Peptic reflux disease","source":"DrugCentral","snomedId":57643001,"regulator":"FDA"},{"name":"Peptic ulcer","source":"DrugCentral","snomedId":13200003,"regulator":"FDA","usPrevalence":null,"globalPrevalence":64000000,"prevalenceMethod":"curated","prevalenceSource":"Aliment Pharmacol Ther, 2009 (PMID:19220208)"},{"name":"Zollinger-Ellison syndrome","source":"DrugCentral","snomedId":53132006,"regulator":"FDA"}],"offLabel":[{"name":"Upper gastrointestinal hemorrhage","source":"DrugCentral","drugName":"dexrabeprazole","evidenceCount":60,"evidenceLevel":"strong"}],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"omeprazole","brandName":"omeprazole","genericName":"omeprazole","approvalYear":"1989","relationship":"same-class"},{"drugId":"pantoprazole","brandName":"pantoprazole","genericName":"pantoprazole","approvalYear":"2000","relationship":"same-class"},{"drugId":"lansoprazole","brandName":"lansoprazole","genericName":"lansoprazole","approvalYear":"1995","relationship":"same-class"},{"drugId":"rabeprazole","brandName":"rabeprazole","genericName":"rabeprazole","approvalYear":"1999","relationship":"same-class"},{"drugId":"esomeprazole","brandName":"esomeprazole","genericName":"esomeprazole","approvalYear":"2001","relationship":"same-class"},{"drugId":"dexlansoprazole","brandName":"dexlansoprazole","genericName":"dexlansoprazole","approvalYear":"2009","relationship":"same-class"}],"trialDetails":[{"nctId":"NCT02689999","phase":"PHASE4","title":"The Effect of Dexrabeprazole on Intragastric and Intraesophageal Acidity","status":"COMPLETED","sponsor":"Neutec Ar-Ge San ve Tic A.Ş","startDate":"2016-02","conditions":["Gastroesophageal Reflux Disease (GERD)"],"enrollment":12,"completionDate":"2017-08"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"65JK8810RM","CHEBI":"CHEBI:134729","UMLSCUI":"C3661450","ChEMBL_ID":"CHEMBL1615209","DRUGBANK_ID":"DB13762","PDB_CHEM_ID":"RZX","PUBCHEM_CID":"9906855","SNOMEDCT_US":"1177188006","SECONDARY_CAS_RN":"171440-18-9","MESH_DESCRIPTOR_UI":"D064750","MESH_SUPPLEMENTAL_RECORD_UI":"C000595232"},"formularyStatus":[],"_enricherVersion":"v2","_offLabelChecked":true,"developmentCodes":[],"ownershipHistory":[],"publicationCount":14,"therapeuticAreas":["Gastroenterology"],"atcClassification":{"source":"DrugCentral","atcCode":"A02BC07","allCodes":["A02BC07"]},"biosimilarFilings":[],"recentPublications":[{"date":"2023","pmid":"37699222","title":"Reply to the letter to the editor \"Clarifications on the safety of dexrabeprazole vs. omeprazole in the treatment of gastroesophageal reflux disease\".","journal":"Gaceta medica de Mexico"},{"date":"2023","pmid":"37699220","title":"Clarifications on the safety of dexrabeprazole vs. omeprazole in the treatment of gastroesophageal reflux disease.","journal":"Gaceta medica de Mexico"},{"date":"2022","pmid":"36657136","title":"Efficacy and safety comparative study of dexrabeprazole vs. esomeprazole for the treatment of gastroesophageal reflux disease.","journal":"Gaceta medica de Mexico"},{"date":"2021","pmid":"32312104","title":"Determination of Proton Pump Inhibitors by Spectrophotometric, Chromatographic and by Hyphenated Techniques: A Review.","journal":"Critical reviews in analytical chemistry"},{"date":"2019 Nov","pmid":"31281995","title":"Chiral separation of lansoprazole and rabeprazole by capillary electrophoresis using dual cyclodextrin systems.","journal":"Electrophoresis"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"Dexpure (dexrabeprazole) is a proton pump inhibitor (PPI) small molecule developed to target the proto-oncogene tyrosine-protein kinase receptor Ret. It is used to treat various gastrointestinal conditions, including duodenal ulcers, erosive esophagitis, and gastroesophageal reflux disease. The commercial status of Dexpure is currently unknown, and it has not been approved by the FDA. Key safety considerations include potential interactions with other medications and the risk of osteoporosis with long-term use. Dexpure works by reducing stomach acid production.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":true,"score":3}}