{"id":"dexniguldipine","rwe":[{"pmid":"22257057","year":"2012","title":"Three decades of P-gp inhibitors: skimming through several generations and scaffolds.","finding":"","journal":"Current medicinal chemistry","studyType":"Clinical Study"},{"pmid":"17937779","year":"2007","title":"Dihydropyridine derivatives to overcome atypical multidrug resistance: design, synthesis, QSAR studies, and evaluation of their cytotoxic and pharmacological activities.","finding":"","journal":"Chemical biology & drug design","studyType":"Clinical Study"},{"pmid":"16842198","year":"2006","title":"Multidrug resistance: retrospect and prospects in anti-cancer drug treatment.","finding":"","journal":"Current medicinal chemistry","studyType":"Clinical Study"},{"pmid":"12071854","year":"2002","title":"Transport of phosphatidylserine via MDR1 (multidrug resistance 1)P-glycoprotein in a human gastric carcinoma cell line.","finding":"","journal":"The Biochemical journal","studyType":"Clinical Study"},{"pmid":"12021398","year":"2002","title":"Characterization of the dexniguldipine binding site in the multidrug resistance-related transport protein P-glycoprotein by photoaffinity labeling and mass spectrometry.","finding":"","journal":"Molecular pharmacology","studyType":"Clinical Study"}],"tags":[{"label":"dexniguldipine","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Alpha-1A adrenergic receptor","category":"target"},{"label":"ADRA1A","category":"gene"},{"label":"ABCB1","category":"gene"},{"label":"ADRA1B","category":"gene"},{"label":"Active","category":"status"},{"label":"Antihypertensive Agents","category":"pharmacology"},{"label":"Antineoplastic Agents","category":"pharmacology"},{"label":"Calcium Channel Blockers","category":"pharmacology"},{"label":"Calcium-Regulating Hormones and Agents","category":"pharmacology"},{"label":"Cardiovascular Agents","category":"pharmacology"},{"label":"Membrane Transport Modulators","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"niguldipine fumarate","offLabel":[],"synonyms":["niguldipine hydrobromide","niguldipine fumarate","niguldipine hydrochloride","niguldipine HCl","B859-35","B 859-35","B8509-035","dexniguldipine","(+)-Niguldipine","(R)-Niguldipine"],"timeline":[],"aiSummary":"Niguldipine fumarate is a small molecule with the synonyms DEXNIGULDIPINE, DEXNIGULDIPINO, and (R)-NIGULDIPINE.","approvals":[],"brandName":"Niguldipine Fumarate","ecosystem":[],"mechanism":{"target":"Adenosine receptor A3, Multidrug resistance protein 1, Alpha-1A adrenergic receptor","targets":[{"gene":"ADRA1A","source":"DrugCentral","target":"Alpha-1A adrenergic receptor","protein":"Alpha-1A adrenergic receptor"},{"gene":"ABCB1","source":"DrugCentral","target":"Multidrug resistance protein 1","protein":"Multidrug resistance protein 1"},{"gene":"ADRA1B","source":"DrugCentral","target":"Alpha-1B adrenergic receptor","protein":"Alpha-1B adrenergic receptor"},{"gene":"ADRA1D","source":"DrugCentral","target":"Alpha-1D adrenergic receptor","protein":"Alpha-1D adrenergic receptor"},{"gene":"ADRA2C","source":"DrugCentral","target":"Alpha-2C adrenergic receptor","protein":"Alpha-2C adrenergic receptor"},{"gene":"ADRA2B","source":"DrugCentral","target":"Alpha-2B adrenergic receptor","protein":"Alpha-2B adrenergic receptor"},{"gene":"ADRA2A","source":"DrugCentral","target":"Alpha-2A adrenergic receptor","protein":"Alpha-2A adrenergic receptor"},{"gene":"CACNA1H","source":"DrugCentral","target":"Voltage-dependent T-type calcium channel subunit alpha-1H","protein":"Voltage-dependent T-type calcium channel subunit alpha-1H"},{"gene":"ADORA3","source":"DrugCentral","target":"Adenosine receptor A3","protein":"Adenosine receptor A3"},{"gene":"CACNA1C","source":"DrugCentral","target":"Voltage-gated L-type calcium channel","protein":"Voltage-dependent L-type calcium channel subunit alpha-1C"}],"modality":"Small Molecule","drugClass":"dexniguldipine","explanation":"Imagine your blood vessels are like roads in your body. When they constrict, it's like narrowing the roads, which can increase blood pressure. DEXNIGULDIPINE helps to keep these roads open by blocking a specific receptor that causes them to constrict.","oneSentence":"DEXNIGULDIPINE works by selectively blocking the Alpha-1A adrenergic receptor, which helps to regulate blood vessel constriction and blood pressure.","technicalDetail":"DEXNIGULDIPINE acts as a selective antagonist of the Alpha-1A adrenergic receptor, which is a subtype of adrenergic receptors that play a crucial role in regulating vascular tone and blood pressure."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/837","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=DEXNIGULDIPINE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T10:37:08.962683","biosimilars":[],"competitors":[{"drugName":"amfetamine","drugSlug":"amfetamine","fdaApproval":"1955-09-09","relationship":"same-target"},{"drugName":"amiodarone","drugSlug":"amiodarone","fdaApproval":"1985-12-24","patentExpiry":"Mar 13, 2029","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"amisulpride","drugSlug":"amisulpride","fdaApproval":"2020-02-26","patentExpiry":"Mar 10, 2031","patentStatus":"Patent 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