{"id":"dexmetomidine-intravenously","safety":{"commonSideEffects":[{"rate":"15-30","effect":"Hypotension"},{"rate":"10-25","effect":"Bradycardia"},{"rate":"5-15","effect":"Hypertension (transient, initial)"},{"rate":"5-10","effect":"Dry mouth"},{"rate":"5-10","effect":"Tachycardia (rebound)"}]},"_chembl":{"chemblId":"CHEMBL2109039","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"By binding to alpha-2 adrenergic receptors, dexmedetomidine reduces norepinephrine release and enhances inhibitory neurotransmission, resulting in sedation without respiratory depression. It also provides analgesic and anxiolytic effects, making it useful for procedural sedation and ICU sedation. The drug maintains airway reflexes better than many other sedatives, which is a key clinical advantage.","oneSentence":"Dexmedetomidine is a selective alpha-2 adrenergic receptor agonist that produces sedation, analgesia, and anxiolysis by activating presynaptic and postsynaptic alpha-2 receptors in the central nervous system.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:44:32.294Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Sedation of initially intubated and mechanically ventilated patients in intensive care units"},{"name":"Sedation and analgesia for procedural sedation in awake, non-intubated patients"}]},"trialDetails":[{"nctId":"NCT05840328","phase":"PHASE4","title":"DEXMEDETOMIDINE in NORMAL VAGINAL DELIVERY","status":"UNKNOWN","sponsor":"Menoufia University","startDate":"2022-12-05","conditions":"Painless Vainal Labour","enrollment":60},{"nctId":"NCT02966249","phase":"PHASE4","title":"Dexmetomidine Intrathecally and Intravenously Additionally to Spinal Anaesthesia, in Total Knee Arthroplasty","status":"UNKNOWN","sponsor":"KAT General Hospital","startDate":"2016-10","conditions":"Neuromuscular Block","enrollment":90}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["DEX"],"phase":"marketed","status":"active","brandName":"Dexmetomidine intravenously","genericName":"Dexmetomidine intravenously","companyName":"KAT General Hospital","companyId":"kat-general-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Dexmedetomidine is an intravenous medication that has been studied for use in painless vaginal labor and as an alternative to local anesthetics such as bupivacaine for analgesia in normal vaginal delivery. The exact mechanism of action of dexmedetomidine is currently unknown.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}