{"id":"dexmedetomidine-load","safety":{"commonSideEffects":[{"rate":"15-30","effect":"Hypotension"},{"rate":"10-25","effect":"Bradycardia"},{"rate":"5-15","effect":"Hypertension (transient, initial)"},{"rate":"5-10","effect":"Dry mouth"},{"rate":"5-10","effect":"Tachycardia (rebound)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Dexmedetomidine binds with high selectivity to alpha-2 adrenergic receptors, particularly in the locus coeruleus and other brainstem regions, resulting in decreased norepinephrine release and subsequent sedation. This mechanism also provides analgesic and anxiolytic effects while maintaining a unique 'cooperative sedation' profile where patients remain arousable. The drug is the active d-enantiomer of medetomidine and has a rapid onset and short duration of action.","oneSentence":"Dexmedetomidine is a selective alpha-2 adrenergic agonist that produces sedation, analgesia, and anxiolysis by activating alpha-2 receptors in the central nervous system.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:32:40.940Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Sedation of intubated and mechanically ventilated patients in intensive care settings"},{"name":"Procedural sedation in perioperative and diagnostic settings"}]},"trialDetails":[{"nctId":"NCT07292324","phase":"PHASE4","title":"Continuous Epidural With Dexmedetomidine Adjuvant in Gynecologic Laparotomy","status":"COMPLETED","sponsor":"Udayana University","startDate":"2025-08-21","conditions":"Post Operative Pain, Acute, Chronic Post Surgical Pain, Gynecologic Disease","enrollment":62},{"nctId":"NCT06936410","phase":"PHASE2","title":"Using Lidocaine or Dexmedetomidine to Help Control Blood Pressure Spikes From a Tourniquet During Knee Surgery","status":"COMPLETED","sponsor":"Cairo University","startDate":"2025-03-01","conditions":"Tourniquet Hypertension","enrollment":186},{"nctId":"NCT07462195","phase":"PHASE4","title":"Dexmedetomidine for Improving Emergence Quality in Thyroid Surgery","status":"NOT_YET_RECRUITING","sponsor":"Bach Mai Hospital","startDate":"2026-03","conditions":"Thyroid Diseases","enrollment":100},{"nctId":"NCT04772222","phase":"PHASE2","title":"Dexmedetomidine Use in Infants Undergoing Cooling Due to Neonatal Encephalopathy (DICE Trial)","status":"COMPLETED","sponsor":"University of Utah","startDate":"2022-06-20","conditions":"Hypoxic-Ischemic Encephalopathy, Pain","enrollment":50},{"nctId":"NCT07377981","phase":"PHASE4","title":"An Exploratory Study of the Efficacy and Safety of Esketamine and Dexmedetomidine in Non-Intubated ICU Patients With Hyperactive Delirium","status":"NOT_YET_RECRUITING","sponsor":"The First Affiliated Hospital with Nanjing Medical University","startDate":"2026-02-22","conditions":"Dexmedetomidine, Ketamine, Analgesia","enrollment":86},{"nctId":"NCT07443163","phase":"PHASE3","title":"Comparison Between Total Intravenous Anesthesia With Magnesium Sulphate Versus Total Intravenous Anesthesia With Dexmedetomidine in Patients Undergoing Lumbar Spine Surgeries","status":"NOT_YET_RECRUITING","sponsor":"Cairo University","startDate":"2026-03","conditions":"Emergence From Anesthesia","enrollment":40},{"nctId":"NCT07425444","phase":"PHASE4","title":"Attenuate the Stress Response in Laparoscopic Cholecystectomy","status":"NOT_YET_RECRUITING","sponsor":"Assiut University","startDate":"2026-02","conditions":"Laparoscopic Cholecystectomy Surgery","enrollment":50},{"nctId":"NCT06431178","phase":"NA","title":"General Anesthesia Versus Sedation By Dexmedetomidine and Ketamine With Local Infiltration for Percutaneous Transcatheter Closure of Atrial Septal Defect in Pediatric Patients","status":"COMPLETED","sponsor":"Tanta University","startDate":"2024-05-01","conditions":"General Anesthesia, Dexmedetomidine, Ketamine","enrollment":60},{"nctId":"NCT07412223","phase":"PHASE4","title":"Effect of Tegileridine on Postoperative Bowel Function Recovery in Abdominal Surgery","status":"NOT_YET_RECRUITING","sponsor":"Xiangya Hospital of Central South University","startDate":"2026-02-24","conditions":"Pain, Postoperative, Postoperative Ileus","enrollment":152},{"nctId":"NCT07149545","phase":"NA","title":"Electrophysiologist-led Deep Sedation Protocols for Pulsed Field Ablation for Atrial Fibrillation Using a Bipolar Tip-Catheter: The DEEP-PFA Randomized Controlled Trial","status":"COMPLETED","sponsor":"Beijing Anzhen Hospital","startDate":"2025-10-15","conditions":"Atrial Fibrillation (AF), PFA, Deep Sedation","enrollment":240},{"nctId":"NCT06878703","phase":"PHASE3","title":"Efficacy of Dexmedetomidine Versus Midazolam Sedation on Extubation Time in Mechanically Ventilated Preterm Infants","status":"RECRUITING","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2025-10-16","conditions":"PreTerm Neonate, Sedation for Invasive Mechanical Ventilation, Very Preterm Neonates With Sedation for Invasive Mechanical Ventilation","enrollment":380},{"nctId":"NCT07384169","phase":"","title":"Cognitive Function in Geriatric Colonoscopy Patients","status":"COMPLETED","sponsor":"Ankara City Hospital Bilkent","startDate":"2023-08-01","conditions":"Cognition, Sedation, Geriatric Anesthesia","enrollment":164},{"nctId":"NCT07398066","phase":"NA","title":"DEXmedetomidine for Postoperative Analgesia and Delirium Prevention After NEUROsurgery (DEX-NEURO Trial)","status":"NOT_YET_RECRUITING","sponsor":"University of Malaya","startDate":"2026-07-22","conditions":"Neurosurgery, Brain Cancer, Meningioma","enrollment":60},{"nctId":"NCT07392983","phase":"NA","title":"Comparison of Effect of Dexmedetomidine and Midazolam on Emergence Agitation","status":"COMPLETED","sponsor":"Muhammad Aamir Latif","startDate":"2025-07-01","conditions":"Emergence Agitation","enrollment":146},{"nctId":"NCT07231926","phase":"NA","title":"Intrathecal Morphine for Recovery and Outcomes After VATS","status":"RECRUITING","sponsor":"Ataturk University","startDate":"2025-12-01","conditions":"Postoperative Pain Management in Video-Assisted Thoracoscopic Surgery","enrollment":52},{"nctId":"NCT07389096","phase":"PHASE4","title":"Opioid-Free Anesthesia Versus Opioid Based Anesthesia For Adolescent Idiopathic Scoliosis","status":"RECRUITING","sponsor":"Nashwa Ahmed","startDate":"2026-01-30","conditions":"Opioid Free Anesthesia","enrollment":30},{"nctId":"NCT04871308","phase":"NA","title":"Dexmedetomidine and Myocardial Protection","status":"COMPLETED","sponsor":"Seoul National University Hospital","startDate":"2021-07-07","conditions":"Cardiac Surgery, Cardiopulmonary Bypass","enrollment":224},{"nctId":"NCT05303987","phase":"PHASE2","title":"Dexmedetomidine Versus Propofol Sedation for Drug-Induced Sleep Endoscopy in Pediatric Obstructive Sleep Apnea","status":"RECRUITING","sponsor":"Erin Kirkham","startDate":"2022-10-05","conditions":"Obstructive Sleep Apnea","enrollment":90},{"nctId":"NCT07363681","phase":"NA","title":"Inhalational Agents Versus Dexmedetomidine for Maintenance of General Anesthesia","status":"RECRUITING","sponsor":"Bakirkoy Dr. Sadi Konuk Research and Training Hospital","startDate":"2024-10-01","conditions":"Ureterorenoscopic Lithotripsy, Transurethral Resection of the Bladder, Percutaneous Nephrolithotomy","enrollment":150},{"nctId":"NCT05788393","phase":"PHASE4","title":"Opioid Sparing Analgesia Continuous Intraoperative Infusion of Dexmedetomidine Versus Lidocaine for Laparoscopic Cholecystectomy","status":"COMPLETED","sponsor":"Assiut University","startDate":"2024-04-01","conditions":"Analgesia","enrollment":64},{"nctId":"NCT07330375","phase":"PHASE3","title":"Effect of Intravenous Dexmedetomidine and Ketamine on Post-Operative Analgesia","status":"NOT_YET_RECRUITING","sponsor":"Zagazig University","startDate":"2026-01-20","conditions":"Postoperative Analgesia, Postoperative Pain Management","enrollment":50},{"nctId":"NCT07326332","phase":"NA","title":"Effect of Dexmedetomidine on Tear Production in Angioplasty Patients","status":"NOT_YET_RECRUITING","sponsor":"Benha University","startDate":"2026-01-01","conditions":"Tear Film Alteration","enrollment":52},{"nctId":"NCT07308756","phase":"PHASE4","title":"Impact of Perioperative Dexmedetomidine and Esketamine on Postoperative Quality of Recovery","status":"NOT_YET_RECRUITING","sponsor":"Peking University First Hospital","startDate":"2025-12","conditions":"General Anesthesia, Surgery, Dexmedetomidine","enrollment":316},{"nctId":"NCT07306702","phase":"PHASE4","title":"Dexmedetomidine-Enhanced PCIA After Lobectomy in Nicotine-Dependent Patients","status":"COMPLETED","sponsor":"Shenyang Sixth People's Hospital","startDate":"2023-07-01","conditions":"Postoperative Pain Management","enrollment":102},{"nctId":"NCT07307625","phase":"NA","title":"LAPOFAR Trial: Opioid-Free vs. Remifentanil Anesthesia in Laparoscopic Cholecystectomy","status":"COMPLETED","sponsor":"Dr. Lutfi Kirdar Kartal Training and Research Hospital","startDate":"2024-12-15","conditions":"Postoperative Pain Management, Postoperative Nausea and Vomiting, Laparoscopic Cholecystectomy","enrollment":101},{"nctId":"NCT06210061","phase":"NA","title":"Propofol-Fentanyl-Dexmedetomidine and Propofol-Fentanyl-Sevoflurane Anesthesia for Major Spine Surgery Under Somato Sensory- and Motor- Evoked Potential Monitoring","status":"COMPLETED","sponsor":"Ain Shams University","startDate":"2024-01-20","conditions":"Propofol, Fentanyl, Dexmedetomidine","enrollment":78},{"nctId":"NCT06791811","phase":"NA","title":"A Comparative Study Between Opioids Free Anesthesia and Opioid Anesthesia in Patients With Supratentorial Tumor Resection","status":"COMPLETED","sponsor":"Kasr El Aini Hospital","startDate":"2025-03-01","conditions":"Supra-tentorial Tumor","enrollment":86},{"nctId":"NCT06835010","phase":"NA","title":"Sevoflurane and Dexmedetomidine's Contrasting Renal Impacts After Non-Cardiac Surgery","status":"COMPLETED","sponsor":"Tanta University","startDate":"2024-05-20","conditions":"AKI - Acute Kidney Injury","enrollment":90},{"nctId":"NCT04289142","phase":"PHASE4","title":"Cognitive Outcomes After Dexmedetomidine Sedation in Cardiac Surgery Patients","status":"RECRUITING","sponsor":"Sunnybrook Health Sciences Centre","startDate":"2019-12-01","conditions":"Delirium, Cognitive Dysfunction, Cognition Disorder","enrollment":2400},{"nctId":"NCT07073846","phase":"PHASE4","title":"Effect of Lidocaine-Dexmedetomidine on Pain, Inflammation, and Oxidative Stress After Bariatric Surgery.","status":"RECRUITING","sponsor":"Instituto Mexicano del Seguro Social","startDate":"2025-10-06","conditions":"Morbid Obesity Requiring Bariatric Surgery, Postoperative Pain, Postoperative Pain Management","enrollment":104},{"nctId":"NCT07255027","phase":"NA","title":"Study on the Efficacy and Safety of Anesthesia-Induced Sleep Therapy for Refractory Insomnia","status":"NOT_YET_RECRUITING","sponsor":"Beijing Tiantan Hospital","startDate":"2025-12-01","conditions":"Insomnia","enrollment":180},{"nctId":"NCT06662318","phase":"NA","title":"Perioperative Pain Management for Lumbar Spine Surgery","status":"COMPLETED","sponsor":"Benha University","startDate":"2024-10-01","conditions":"Pain, Postoperative","enrollment":75},{"nctId":"NCT03263117","phase":"PHASE4","title":"SEdation Versus General Anesthesia for Endovascular Therapy in Acute Ischemic Stroke","status":"COMPLETED","sponsor":"The University of Texas Health Science Center, Houston","startDate":"2018-07-01","conditions":"Stroke","enrollment":260},{"nctId":"NCT07235605","phase":"NA","title":"Intravenous Sedation and Analgesia Versus Local Anesthesia During Microwave Ablation of Benign Thyroid Nodules","status":"NOT_YET_RECRUITING","sponsor":"Suez University","startDate":"2025-11","conditions":"Benign Thyroid Nodule","enrollment":52},{"nctId":"NCT07105618","phase":"NA","title":"Total Intravenous Anesthesia in Patients Undergoing Craniotomy","status":"RECRUITING","sponsor":"Zagazig University","startDate":"2025-08-10","conditions":"Anesthesia","enrollment":108},{"nctId":"NCT05436964","phase":"NA","title":"Effect of Intraoperative Dexmedetomidine on Postoperative Delirium in Elderly Patients Undergoing Major Abdominal Surgery","status":"COMPLETED","sponsor":"Chinese PLA General Hospital","startDate":"2022-07-01","conditions":"Delirium in Old Age","enrollment":268},{"nctId":"NCT06511128","phase":"","title":"Evaluation of Anesthesia Depth Using 4-channel EEG in Patients Undergoing Drug-induced Sleep Endoscopy (DISE) With Two Different Sedation Methods.","status":"COMPLETED","sponsor":"Ankara City Hospital Bilkent","startDate":"2024-03-05","conditions":"Seeing the Benefits of Using 4 Channel EEG During the DISE Procedure With Sedation","enrollment":50},{"nctId":"NCT06860100","phase":"","title":"The Effect of Preoperative Dexmedetomidine and Tramadol on Sedation, Pain and Haemodynamics in Haemorrhoids Patients","status":"ACTIVE_NOT_RECRUITING","sponsor":"Yuzuncu Yil University","startDate":"2025-11-17","conditions":"Analgesia, Sedation, Anxiety","enrollment":90},{"nctId":"NCT06139692","phase":"PHASE4","title":"Comparison of Perioperative Conscious Sedation During Endovascular Thrombectomy in Acute Ischemic Stroke","status":"RECRUITING","sponsor":"Jinling Hospital, China","startDate":"2023-11-21","conditions":"Acute Ischemic Stroke","enrollment":810},{"nctId":"NCT07214714","phase":"PHASE4","title":"Hemodynamic and Cardiac Effects of Dexmedetomidine Versus Fentanyl by Intravenous Infusion as Adjuncts to General Anesthesia in Patients Undergoing Major Abdominal Cancer Surgeries.","status":"NOT_YET_RECRUITING","sponsor":"Assiut University","startDate":"2025-11-01","conditions":"Abdominal Cancer Surgeries","enrollment":70},{"nctId":"NCT05242692","phase":"EARLY_PHASE1","title":"The Effects of Subanesthetic S-ketamine on Postoperative Delirium and Cognitive Function in the Elderly Undergoing Non-cardiac Thoracic Surgery","status":"COMPLETED","sponsor":"Affiliated Cancer Hospital & Institute of Guangzhou Medical University","startDate":"2022-03-10","conditions":"Postoperative Delirium, Elderly Patients","enrollment":520},{"nctId":"NCT07199595","phase":"NA","title":"Dexmedetomidine Versus Magnesium Sulfate Infusion in Craniotomy","status":"NOT_YET_RECRUITING","sponsor":"Assiut University","startDate":"2025-10-20","conditions":"Craniotomy Surgery","enrollment":60},{"nctId":"NCT06251375","phase":"PHASE4","title":"Early Sedation With Dexmedetomidine vs. Placebo in Older Ventilated Critically Ill Patients","status":"NOT_YET_RECRUITING","sponsor":"St. Joseph's Healthcare Hamilton","startDate":"2025-09-07","conditions":"Respiratory Insufficiency","enrollment":300},{"nctId":"NCT07166614","phase":"NA","title":"Dexmedetomidine vs Propofol in High-Risk ERCP Patients","status":"RECRUITING","sponsor":"Sisli Hamidiye Etfal Training and Research Hospital","startDate":"2025-09-03","conditions":"Respiratory Depression, Hypoxemia, Hypotension Drug-Induced","enrollment":2},{"nctId":"NCT05581485","phase":"NA","title":"Dex vs SLNB in Spontaneous Breathing Via THRIVE for Laryngeal Surgery","status":"COMPLETED","sponsor":"Kaohsiung Veterans General Hospital.","startDate":"2022-11-29","conditions":"Endoscopic Laryngeal Surgery","enrollment":46},{"nctId":"NCT07145814","phase":"NA","title":"Dexmedetomidine Dose-Dependent on Lung Function and AQP1 in One-Lung Ventilation Surgery","status":"COMPLETED","sponsor":"People's Hospital of Guangxi Zhuang Autonomous Region","startDate":"2018-01-05","conditions":"Acute Lung Injury(ALI)","enrollment":60},{"nctId":"NCT05772832","phase":"","title":"COMPARISON OF DEXMEDETOMIDINE AND REMIFENTANIL FOR POSTOPERATIVE PAIN IN TRANSPHENOIDAL Pituitary SURGERY","status":"COMPLETED","sponsor":"Kocaeli University","startDate":"2021-11-17","conditions":"Postoperative Pain","enrollment":104},{"nctId":"NCT06085573","phase":"","title":"A Study to Learn About the Study Medicine - Precedex in Children From Japan.","status":"COMPLETED","sponsor":"Pfizer","startDate":"2023-10-18","conditions":"Sedation","enrollment":111},{"nctId":"NCT06530563","phase":"PHASE4","title":"the Efficacy and Safety of Oliceridine Fumarate Injection for Acute Pain After Abdominal Surgery","status":"NOT_YET_RECRUITING","sponsor":"Xiangya Hospital of Central South University","startDate":"2025-08","conditions":"Acute Pain, Opioid Analgesic Adverse Reaction","enrollment":606},{"nctId":"NCT07101367","phase":"PHASE1, PHASE2","title":"A Comparative Study Between Dexmedetomidine Versus Methylprednisolone on Induced Inflammatory Response in Patients Undergoing On-pump CABG","status":"NOT_YET_RECRUITING","sponsor":"Ain Shams University","startDate":"2025-09-01","conditions":"Coronary Artery Disease, Systemic Inflammatory Response Syndrome, Postoperative Complications","enrollment":60},{"nctId":"NCT03089905","phase":"PHASE3","title":"A Study to Compare the Long-term Outcomes After Two Different Anaesthetics","status":"ACTIVE_NOT_RECRUITING","sponsor":"Murdoch Childrens Research Institute","startDate":"2017-08-10","conditions":"Anesthesia, Neurotoxicity, Child Development","enrollment":450},{"nctId":"NCT06030804","phase":"NA","title":"Perioperative Dexmedetomidine and Long-term Survival After Cancer Surgery","status":"RECRUITING","sponsor":"Peking University First Hospital","startDate":"2023-09-12","conditions":"Elderly, Cancer Surgery, Dexmedetomidine","enrollment":4532},{"nctId":"NCT07088016","phase":"","title":"A Comparative Study Between Lumbar Epidural Analgesia Versus Local Infiltration Anesthesia Combined With Dexmedetomidine Intravenous Infusion in Endoscopic Lumbar Discectomy Surgeries: A Retrospective Study","status":"COMPLETED","sponsor":"Ain Shams University","startDate":"2021-01-01","conditions":"Epidural Analgesics for Comparison","enrollment":100},{"nctId":"NCT07034963","phase":"PHASE1, PHASE2","title":"Study on the Effective Dose and Safety of Esketamine in Hysteroscopic Surgery Under Monitored Anesthesia Care","status":"ACTIVE_NOT_RECRUITING","sponsor":"The First Affiliated Hospital of Xiamen University","startDate":"2025-06-26","conditions":"Intrauterine Polyp, Intrauterine Synechiae","enrollment":95},{"nctId":"NCT06720220","phase":"PHASE3","title":"Role of Airway Topicalization in Awake Fiberoptic Intubation","status":"COMPLETED","sponsor":"Zagazig University","startDate":"2023-06-01","conditions":"Airway Complication of Anesthesia","enrollment":56},{"nctId":"NCT03933306","phase":"PHASE4","title":"Intraoperative Goal-directed Blood Pressure and Dexmedetomidine on Outcomes","status":"COMPLETED","sponsor":"Peking University First Hospital","startDate":"2019-05-20","conditions":"Blood Pressure, Dexmedetomidine, High-risk Patients","enrollment":496},{"nctId":"NCT06653244","phase":"PHASE1","title":"Morphine, Midazolam and Dexmedetomidine in the Management of Acute Cardiogenic Pulmonary Edema, Safety and Efficacy","status":"COMPLETED","sponsor":"Menoufia University","startDate":"2024-04-01","conditions":"Sedative Adverse Reaction","enrollment":84},{"nctId":"NCT05610774","phase":"NA","title":"Optic Nerve Sheath Diameter in Pre-Eclamptic Parturient Receiving Magnesium Sulfate Combined With Dexmedetomidine","status":"COMPLETED","sponsor":"Benha University","startDate":"2023-06-06","conditions":"Preeclampsia Severe, Optic Nerve Sheath Diameter","enrollment":50},{"nctId":"NCT06490731","phase":"PHASE1, PHASE2","title":"Effects of Dexmedetomidine Versus Ketamine on Inflammatory Response and Hemodynamic in Patients","status":"RECRUITING","sponsor":"New Valley University","startDate":"2025-04-01","conditions":"Haemodynamic Rebound","enrollment":2},{"nctId":"NCT06981494","phase":"NA","title":"Dexmedetomidine Versus Dexmedetomidine and Ketamine (Ketodex) in Ear and Nose Surgeries","status":"RECRUITING","sponsor":"Sohag University","startDate":"2025-02-05","conditions":"Ear and Nose Surgeries With Hypotensive Anaesthesia e.g FESS , MLS , TURBINECTOMY","enrollment":84},{"nctId":"NCT06977425","phase":"NA","title":"Efficacy of Intraoperative Magnesium Sulphate vs Dexmedetomidine on Emergence Agitation in Pediatric Patients","status":"COMPLETED","sponsor":"Ain Shams University","startDate":"2024-04-01","conditions":"Magnesium Sulphate, Dexmedetomidine, Emergence Agitation","enrollment":60},{"nctId":"NCT06970626","phase":"PHASE2, PHASE3","title":"Quality of Recovery in Laparoscopic Sleeve Gastrectomy Using Dexmedetomidine Infusion Versus Laparoscopic TAP Block in Combination With Paragastric Neural Block","status":"RECRUITING","sponsor":"Alexandria University","startDate":"2025-04-03","conditions":"Laparoscopic Sleeve Gastrectomy","enrollment":60},{"nctId":"NCT06970678","phase":"PHASE1, PHASE2","title":"Combining Dexmedetomidine Infusion and Paragastric Autonomic Neural Block to Enhance Postoperative Recovery in Patients Undergoing Laparoscopic Sleeve Gastrectomy","status":"RECRUITING","sponsor":"Alexandria University","startDate":"2025-04-04","conditions":"Laparoscopic Sleeve Gastrectomy (LSG)","enrollment":46},{"nctId":"NCT06907277","phase":"NA","title":"Dexmedetomidine Enhancing the Recovery After Cardiac Surgery","status":"COMPLETED","sponsor":"Benha University","startDate":"2024-08-30","conditions":"Post-cardiac Surgery","enrollment":75},{"nctId":"NCT05742438","phase":"NA","title":"Effects of Dexmedetomidine/Lidocaine/Intrathecal Morphine on Cancer Metastasis Biomarker After Colorectal Surgery","status":"COMPLETED","sponsor":"Samsung Medical Center","startDate":"2023-04-12","conditions":"Colorectal Cancer, Anesthesia, Cancer Metastatic","enrollment":114},{"nctId":"NCT06867302","phase":"NA","title":"Dexmedetomidine and Agitation After Nasal Surgery","status":"RECRUITING","sponsor":"Fayoum University Hospital","startDate":"2025-03-01","conditions":"Nasal Disease, Agitation, Emergence","enrollment":50},{"nctId":"NCT06848764","phase":"NA","title":"Lidocaine and Dexmedetomidine Infusions for Intraoperative Bleeding in Functional Endoscopic Sinus Surgery","status":"RECRUITING","sponsor":"Ain Shams University","startDate":"2025-03-01","conditions":"Lidocaine, Dexmedetomidine, Infusion","enrollment":40},{"nctId":"NCT06848595","phase":"PHASE3","title":"Mg Sulfate Versus Dexmedetomidine on Cerebral Oxygen Saturation","status":"NOT_YET_RECRUITING","sponsor":"Tanta University","startDate":"2025-02-23","conditions":"Cerebral Desaturation Events, Spine Surgeries","enrollment":90},{"nctId":"NCT06837519","phase":"NA","title":"Lidocaine and Dexmedetomidine Infusion and Their Combination on Perioperative Pain in Patients Undergoing Video-Assisted Thoracoscopic Surgery","status":"RECRUITING","sponsor":"Ain Shams University","startDate":"2025-02-20","conditions":"Lidocaine, Dexmedetomidine, Infusion","enrollment":75},{"nctId":"NCT06834841","phase":"NA","title":"Dexmedetomidine and Fentanyl As Adjuvants to Hyperbaric Bupivacaine for the Prevention of Post-spinal Shivering in Hip Arthroplasty Surgeries","status":"UNKNOWN","sponsor":"Ain Shams University","startDate":"2024-04-01","conditions":"Post Spinal Shivering","enrollment":100},{"nctId":"NCT06822088","phase":"PHASE4","title":"Effects of Esketamine on Oxygenation and Quality of Recovery in Patients Undergoing Thoracoscopic Surgery","status":"NOT_YET_RECRUITING","sponsor":"Jinqiao Qian","startDate":"2025-03-01","conditions":"Esketamine, One-lung Ventilation, Oxygenation Indices","enrollment":126},{"nctId":"NCT06756178","phase":"EARLY_PHASE1","title":"Effect of Remimazolam Versus Dexmedetomidine on the Incidence of Delirium After Elective Cardiac Surgery with Cardiopulmonary Bypass: a Prospective Randomized Controlled Trial","status":"NOT_YET_RECRUITING","sponsor":"Assiut University","startDate":"2025-01-10","conditions":"Delirium - Postoperative","enrollment":111},{"nctId":"NCT06752863","phase":"PHASE4","title":"Labetalol Infusion and Dexmedetomidine Infusion in Hypotensive Anesthesia","status":"RECRUITING","sponsor":"Ain Shams University","startDate":"2024-11-27","conditions":"Hypotensive Anesthesia, Ear, Nose and Throat Procedure","enrollment":80},{"nctId":"NCT03480061","phase":"PHASE4","title":"Dexmedetomidine to Reduce the Incidence of POCD After Open Cardiac Surgery","status":"ACTIVE_NOT_RECRUITING","sponsor":"Sunnybrook Health Sciences Centre","startDate":"2018-08-09","conditions":"Delirium, Postoperative Cognitive Dysfunction, Dexmedetomidine","enrollment":90},{"nctId":"NCT06719960","phase":"","title":"How Are Cognitive Functions Affected by Different Sedation Methods in Geriatric Patients?","status":"COMPLETED","sponsor":"Ankara City Hospital Bilkent","startDate":"2023-07-20","conditions":"Cognition, Sedation for Gastroenteric Endoscopic Procedure, Geriatric Patients","enrollment":184},{"nctId":"NCT06614881","phase":"NA","title":"Dexmedetomidine Dosage for Postoperative Delirium and Cognitive Function in Elderly TKA Patients","status":"COMPLETED","sponsor":"Tanta University","startDate":"2024-07-01","conditions":"Post Operative Delirium","enrollment":132},{"nctId":"NCT06702488","phase":"PHASE1","title":"Dexmedetomidine and Magnesium Sulfate in the Reduction Cognitive Dysfunction in Geriatrics","status":"RECRUITING","sponsor":"Fayoum University","startDate":"2024-11-21","conditions":"Mental Disorder","enrollment":58},{"nctId":"NCT04364945","phase":"NA","title":"Association Between Anesthetic Drugs for General Anesthesia and Postoperative Intelligence/behavioral Assessment Results in Children","status":"ACTIVE_NOT_RECRUITING","sponsor":"Seoul National University Hospital","startDate":"2020-06-17","conditions":"Anesthesia and Neurotoxicity","enrollment":400},{"nctId":"NCT06565338","phase":"","title":"Comparison Between Effect of Vitamin D Versus Dexmedetomidine in Patients with Head Trauma Using Interleukin 6","status":"COMPLETED","sponsor":"Minia University","startDate":"2021-04-25","conditions":"Traumatic Brain Injury","enrollment":60},{"nctId":"NCT06427707","phase":"PHASE2, PHASE3","title":"The Effect of Adding Either Propofol or Ketamine to Magnesium and Lidocaine Infusions in Nasal Surgeries.","status":"RECRUITING","sponsor":"Ain Shams University","startDate":"2024-06-15","conditions":"Intraoperative Bleeding","enrollment":90},{"nctId":"NCT05778305","phase":"EARLY_PHASE1","title":"Effect of Dexmedetomidine on Left Ventricular Function in Coronary Artery Bypass Graft Surgery Outcome","status":"COMPLETED","sponsor":"Ain Shams University","startDate":"2023-01-29","conditions":"Effect of Drug in CABAG Patients","enrollment":50},{"nctId":"NCT03653832","phase":"PHASE3","title":"Alpha 2 Agonists for Sedation to Produce Better Outcomes From Critical Illness (A2B Trial)","status":"COMPLETED","sponsor":"University of Edinburgh","startDate":"2018-12-10","conditions":"Critical Illness","enrollment":1437},{"nctId":"NCT06575179","phase":"PHASE4","title":"Dexmedetomidine Reduces Sevoflurane MAC-BAR During Pneumoperitoneum","status":"RECRUITING","sponsor":"Fujian Provincial Hospital","startDate":"2024-09-02","conditions":"Laparoscopic Cholecystectomy","enrollment":90},{"nctId":"NCT03289325","phase":"NA","title":"Dexmedetomidine and Long-term Outcomes in Elderly Patients After Cardiac Surgery","status":"COMPLETED","sponsor":"Peking University First Hospital","startDate":"2021-10-21","conditions":"Cardiac Surgery, Dexmedetomidine, Long-term Outcome","enrollment":285},{"nctId":"NCT06581731","phase":"NA","title":"Comparison of Remifentanil with a Combination of Remimazolam and Dexmedetomidine for Awake Tracheal Intubation","status":"RECRUITING","sponsor":"Nanjing First Hospital, Nanjing Medical University","startDate":"2024-09-19","conditions":"Difficult or Failed Intubation, Sedative Adverse Reaction","enrollment":60},{"nctId":"NCT06587620","phase":"NA","title":"Tranexamic Acid Versus Dexmedetomidine for Improving Surgical Field Quality During Spine Surgeries","status":"COMPLETED","sponsor":"Zagazig University","startDate":"2023-12-01","conditions":"Surgical Field Quality Improvement in Spine Surgeries","enrollment":78},{"nctId":"NCT06551259","phase":"PHASE4","title":"Effect of Dexmedetomidine on Central Nervous System Complications in Patients Undergoing Cardiac Surgery","status":"COMPLETED","sponsor":"Chinese PLA General Hospital","startDate":"2024-01-01","conditions":"Randomized Controlled Trial, Dexmedetomidine","enrollment":200},{"nctId":"NCT02053766","phase":"NA","title":"Anesthesia in Patients With Mitochondrial Disease","status":"TERMINATED","sponsor":"The University of Texas Health Science Center, Houston","startDate":"2014-01-10","conditions":"Mitochondrial Diseases","enrollment":19},{"nctId":"NCT06550414","phase":"NA","title":"Dexmedetomidine As An Adjuvant To Bupivacaine 0.1% in Labor Analgesia","status":"COMPLETED","sponsor":"Services Institute of Medical Sciences, Pakistan","startDate":"2022-11-01","conditions":"Labor Analgesia, Labor Pain","enrollment":165},{"nctId":"NCT06493396","phase":"NA","title":"Effect of Opioid-free Anesthesia on Sleep Quality, Cognitive Function and Recovery Quality After General Anesthesia in Elderly Patients","status":"NOT_YET_RECRUITING","sponsor":"Beijing Friendship Hospital","startDate":"2024-08-01","conditions":"Opioid-Free Anesthesia, POCD, Recovery Quality","enrollment":88},{"nctId":"NCT06464263","phase":"NA","title":"Dexmedetomidine Versus Midazolam-Fentanyl for Analgesia and Sedation","status":"RECRUITING","sponsor":"Egymedicalpedia","startDate":"2024-02-10","conditions":"Valvular Cardiac Surgeries","enrollment":60},{"nctId":"NCT02631135","phase":"PHASE4","title":"Cognitive Functions After TIVA With Dexmedetomidine","status":"COMPLETED","sponsor":"Uludag University","startDate":"2008-01","conditions":"Postoperative Confusion","enrollment":40},{"nctId":"NCT06414395","phase":"PHASE4","title":"The Effects of Different Loading Doses of Dexmedetomidine on The Bispectral Index-Guided Propofol Sedation in Patients Undergoing Advanced Upper Gastrointestinal Endoscopic Procedures: A Randomized Control Study","status":"RECRUITING","sponsor":"Theodor Bilharz Research Institute","startDate":"2024-05-01","conditions":"GIT Endoscopy, Procedural Sedation","enrollment":52},{"nctId":"NCT06409104","phase":"NA","title":"Propofol Versus Dexmedetomidine for Sedation of Cancer Patients Undergoing ERCP","status":"COMPLETED","sponsor":"National Cancer Institute, Egypt","startDate":"2023-09-01","conditions":"Sedation in ERCP","enrollment":202},{"nctId":"NCT06305221","phase":"NA","title":"Effect of Opioid-free Analgesia and Anesthesia on the Quality of Postoperative Recovery and Nausea Vomit in Patients Receiving Laparoscopic Sleeve Gastrectomy","status":"RECRUITING","sponsor":"Beijing Friendship Hospital","startDate":"2024-03-09","conditions":"Opioid-Free Anesthesia, Laparoscopic Sleeve Gastrectomy, Postoperative Vomiting","enrollment":76},{"nctId":"NCT06366412","phase":"PHASE4","title":"Dexmedetomidine on Postoperative Cognitive Dysfunction and Serum Tau-217 Protein.","status":"RECRUITING","sponsor":"Minia University Hospital","startDate":"2024-04","conditions":"Cognitive Impairment","enrollment":94},{"nctId":"NCT06139926","phase":"PHASE3","title":"Clinical Study of Dexmedetomidine Administered Intranasally to Relieve Perioperative Anxiety and Depression in Patients With Colorectal Tumors","status":"RECRUITING","sponsor":"First Affiliated Hospital of Chongqing Medical University","startDate":"2023-12-01","conditions":"Colorectal Cancer","enrollment":126},{"nctId":"NCT06354478","phase":"NA","title":"IV Dexmedetomidine vs Oral Gabapentin and Their Combination for Postoperative Analgesia in Cancer Patients Undergoing Modified Radical Mastectomy","status":"COMPLETED","sponsor":"National Cancer Institute, Egypt","startDate":"2021-01-01","conditions":"Breast Cancer, Pain, Postoperative, Pain, Acute","enrollment":90},{"nctId":"NCT05781854","phase":"PHASE2, PHASE3","title":"Dexmedetomidine for Intermittent Epidural Boluses Versus Continuous Epidural Infusion for Labour Epidural Analgesia","status":"RECRUITING","sponsor":"Assiut University","startDate":"2023-05-29","conditions":"Labor Pain","enrollment":60},{"nctId":"NCT06238011","phase":"NA","title":"Dexmedetomidine vs Control on Attenuation Hemodynamic Response to Noxious Stimuli in CABG Surgical Patients","status":"UNKNOWN","sponsor":"Sawanpracharak hospital","startDate":"2024-02-28","conditions":"CABG","enrollment":60}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":2,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Precedex","Dexmedetomidine Hydrochloride"],"phase":"marketed","status":"active","brandName":"Dexmedetomidine load","genericName":"Dexmedetomidine load","companyName":"University of Pennsylvania","companyId":"university-of-pennsylvania","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Dexmedetomidine is a selective alpha-2 adrenergic agonist that produces sedation, analgesia, and anxiolysis by activating alpha-2 receptors in the central nervous system. Used for Sedation of intubated and mechanically ventilated patients in intensive care settings, Procedural sedation in perioperative and diagnostic settings.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}