{"id":"dexmedetomidine-in","safety":{"commonSideEffects":[{"rate":"15-30","effect":"Hypotension"},{"rate":"10-25","effect":"Bradycardia"},{"rate":"5-15","effect":"Hypertension (transient, initial)"},{"rate":"5-10","effect":"Dry mouth"},{"rate":"5-10","effect":"Headache"},{"rate":"5-10","effect":"Rebound hypertension on withdrawal"}]},"_chembl":null,"_dailymed":{"setId":"aea9a3ad-c244-42be-9cd3-5df83fe2b522","title":"DEXMEDETOMIDINE HYDROCHLORIDE IN 0.9% SODIUM CHLORIDE INJECTION [BAXTER HEALTHCARE COMPANY]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"By binding to alpha-2 adrenergic receptors, dexmedetomidine reduces norepinephrine release and enhances inhibitory neurotransmission, resulting in sedation without respiratory depression. It also provides analgesic and anxiolytic effects through spinal and supraspinal mechanisms. 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