{"id":"dexmedetomidine-esketamine-ropivacaine-combination-1","safety":{"commonSideEffects":[{"rate":null,"effect":"Hypotension"},{"rate":null,"effect":"Bradycardia"},{"rate":null,"effect":"Sedation"},{"rate":null,"effect":"Dissociative effects"},{"rate":null,"effect":"Local anesthetic toxicity"}]},"_chembl":{"chemblId":"CHEMBL1077896","moleculeType":"Small molecule","molecularWeight":"274.41"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Dexmedetomidine acts as a selective alpha-2 adrenergic agonist producing sedation and analgesia. Esketamine is an NMDA receptor antagonist providing dissociative anesthesia and analgesia. Ropivacaine is a local anesthetic that blocks sodium channels in nerve fibers. Together, this combination provides multimodal anesthesia and analgesia for procedural use.","oneSentence":"This combination provides sedation and analgesia through alpha-2 adrenergic agonism (dexmedetomidine), dissociative anesthesia (esketamine), and local anesthetic blockade (ropivacaine).","_ai_confidence":"low"},"_scrapedAt":"2026-03-27T23:44:30.794Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Local/regional anesthesia with sedation and analgesia for procedures"}]},"trialDetails":[{"nctId":"NCT07145775","phase":"PHASE4","title":"Dexmedetomidine-esketamine-ropivacaine Versus Sufentanil-ropivacaine for Epidural Labor Analgesia","status":"NOT_YET_RECRUITING","sponsor":"Peking University First Hospital","startDate":"2025-08","conditions":"Epidural Analgesia, Labor Pain, Sufentanil","enrollment":300}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":467,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["epidural analgesia using the dexmedetomidine-esketamine-ropivacaine combination 1"],"phase":"marketed","status":"active","brandName":"dexmedetomidine-esketamine-ropivacaine combination 1","genericName":"dexmedetomidine-esketamine-ropivacaine combination 1","companyName":"Peking University First Hospital","companyId":"peking-university-first-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This combination provides sedation and analgesia through alpha-2 adrenergic agonism (dexmedetomidine), dissociative anesthesia (esketamine), and local anesthetic blockade (ropivacaine). Used for Local/regional anesthesia with sedation and analgesia for procedures.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}