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The combination leverages complementary mechanisms to achieve balanced sedation with potentially reduced dosing requirements for each agent.","oneSentence":"Dexmedetomidine and propofol are combined sedative agents that work synergistically to produce sedation and anesthesia through alpha-2 adrenergic receptor agonism and GABA-A receptor potentiation, respectively.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:32:39.944Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Sedation in intensive care units"},{"name":"Procedural sedation"},{"name":"Perioperative sedation and anesthesia"}]},"trialDetails":[{"nctId":"NCT07191652","phase":"","title":"The Relationship Between Opioid-Free Anesthesia and Postoperative Agitation-Delirium and Quality of Recovery in Pediatric Ear, Nose, and Throat Cases Monitored With Perioperative Bispectral Index","status":"RECRUITING","sponsor":"Istanbul University - Cerrahpasa","startDate":"2026-03-25","conditions":"Ear Throat Nose Surgery, Delirium - Postoperative, Pain Postoperative","enrollment":120},{"nctId":"NCT07486336","phase":"NA","title":"Awareness Neuraxial Versus General Anesthesia in Frail Patients Undergoing Laparoscopic or Robotic Abdominopelvic Surgery.","status":"NOT_YET_RECRUITING","sponsor":"Ente Ospedaliero Ospedali Galliera","startDate":"2026-09-01","conditions":"Fraily, Abdominal Surgery, Postoperative Cognitive Dysfunction (POCD)","enrollment":100},{"nctId":"NCT07462195","phase":"PHASE4","title":"Dexmedetomidine for Improving Emergence Quality in Thyroid Surgery","status":"NOT_YET_RECRUITING","sponsor":"Bach Mai Hospital","startDate":"2026-03","conditions":"Thyroid Diseases","enrollment":100},{"nctId":"NCT07460310","phase":"NA","title":"Comparison of Anesthetic Techniques for Early Recovery After Ankle Arthroscopy","status":"NOT_YET_RECRUITING","sponsor":"Second Affiliated Hospital, School of Medicine, Zhejiang University","startDate":"2026-03-01","conditions":"Ankle Sprain, Ankle (Ligaments); Instability (Old Injury), Pain Management","enrollment":200},{"nctId":"NCT07120230","phase":"NA","title":"Tubeless Strategy in Lung Transplantation: A Prospective Single-Arm Study","status":"COMPLETED","sponsor":"The First Affiliated Hospital of Guangzhou Medical University","startDate":"2025-08-03","conditions":"Lung Transplant Recipient","enrollment":30},{"nctId":"NCT07337135","phase":"NA","title":"Opioid-Free vs Opioid-Based Anesthesia in Bariatric Surgery","status":"COMPLETED","sponsor":"Hospital dos Lusíadas","startDate":"2023-10-02","conditions":"Morbid Obesity, Postoperative Pain, Opioid Free Anesthesia","enrollment":60},{"nctId":"NCT07423676","phase":"","title":"Comparison Between Two Drugs in Sedation of Upper GI Endoscopy","status":"NOT_YET_RECRUITING","sponsor":"Zagazig University","startDate":"2026-03-01","conditions":"Sedation During GI Endoscopy","enrollment":52},{"nctId":"NCT07211399","phase":"EARLY_PHASE1","title":"Transition From Acute to Chronic Opioid Use and Chronic Pain","status":"NOT_YET_RECRUITING","sponsor":"Jacques E. 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