{"id":"dexmedetomidine-administered-intranasally","safety":{"commonSideEffects":[{"rate":null,"effect":"Hypotension"},{"rate":null,"effect":"Bradycardia"},{"rate":null,"effect":"Dry mouth"},{"rate":null,"effect":"Sedation/drowsiness"},{"rate":null,"effect":"Rebound hypertension"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Dexmedetomidine binds with high selectivity to alpha-2 adrenergic receptors, which are distributed throughout the brain and spinal cord. This activation leads to decreased norepinephrine release and reduced neuronal firing, resulting in sedative and analgesic effects. 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