{"id":"dexmedetomidine-80-g","safety":{"commonSideEffects":[{"rate":"15-30","effect":"Hypotension"},{"rate":"10-25","effect":"Bradycardia"},{"rate":"5-15","effect":"Hypertension (transient, initial)"},{"rate":"5-10","effect":"Dry mouth"},{"rate":"5-10","effect":"Tachycardia (rebound)"},{"rate":"5-10","effect":"Nausea"}]},"_chembl":{"chemblId":"CHEMBL2106195","moleculeType":"Small molecule","molecularWeight":"236.75"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Dexmedetomidine binds with high selectivity to alpha-2 adrenergic receptors, particularly in the locus coeruleus and other brainstem regions, leading to decreased norepinephrine release and reduced neuronal firing. This results in a unique sedative state characterized by maintained airway reflexes and the ability to be aroused, along with analgesic and anxiolytic effects. The drug is the active d-enantiomer of medetomidine and is approximately 1600-fold more selective for alpha-2 versus alpha-1 receptors.","oneSentence":"Dexmedetomidine is a selective alpha-2 adrenergic receptor agonist that produces sedation, analgesia, and anxiolysis by activating presynaptic and postsynaptic alpha-2 receptors in the central nervous system.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:44:27.856Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Sedation of intubated and mechanically ventilated patients in intensive care settings"},{"name":"Sedation and analgesia during procedural sedation"},{"name":"Perioperative anxiolysis and sedation"}]},"trialDetails":[{"nctId":"NCT06627816","phase":"NA","title":"Efficacy of Intravenous Nefopam, Dexmedetomidine, and Meperidine in Preventing Post-Spinal Anesthesia Shivering in Adult Patients Undergoing Lower Abdominal and Lower Limb Surgeries.","status":"COMPLETED","sponsor":"Kasr El Aini Hospital","startDate":"2025-01-10","conditions":"Nefopam, Dexmeditomidine, Meperidine","enrollment":240},{"nctId":"NCT05435560","phase":"EARLY_PHASE1","title":"Neurochemical Mechanisms of the Awake vs. Anesthetized Brain","status":"UNKNOWN","sponsor":"Massachusetts General Hospital","startDate":"2022-04-12","conditions":"Anesthesia, Healthy","enrollment":30},{"nctId":"NCT04718714","phase":"PHASE4","title":"Effects of Dexmedetomidine vs Propofol in Patients With Intra-abdominal Sepsis","status":"COMPLETED","sponsor":"Assiut University","startDate":"2021-01-23","conditions":"Septic Peritonitis","enrollment":60},{"nctId":"NCT03064633","phase":"PHASE4","title":"Dexamethasone Versus Dexmedetomidine","status":"COMPLETED","sponsor":"Fayoum University Hospital","startDate":"2017-03-08","conditions":"Postoperative Pain","enrollment":54},{"nctId":"NCT03393988","phase":"PHASE4","title":"Techniques for Perioperative Analgesia for Live Liver Donors; A Pilot Study","status":"UNKNOWN","sponsor":"Ain Shams University","startDate":"2017-12-07","conditions":"Anesthesia","enrollment":20}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["precedex 100 µg/ml"],"phase":"marketed","status":"active","brandName":"dexmedetomidine 80 µg","genericName":"dexmedetomidine 80 µg","companyName":"Fayoum University Hospital","companyId":"fayoum-university-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Dexmedetomidine is a selective alpha-2 adrenergic receptor agonist that produces sedation, analgesia, and anxiolysis by activating presynaptic and postsynaptic alpha-2 receptors in the central nervous system. Used for Sedation of intubated and mechanically ventilated patients in intensive care settings, Sedation and analgesia during procedural sedation, Perioperative anxiolysis and sedation.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}