{"id":"dexmedetomidine-01","safety":{"commonSideEffects":[{"rate":"15-25","effect":"Hypotension"},{"rate":"10-20","effect":"Bradycardia"},{"rate":"5-15","effect":"Hypertension (transient, dose-dependent)"},{"rate":"5-10","effect":"Dry mouth"},{"rate":"5","effect":"Headache"},{"rate":"null","effect":"Rebound hypertension on discontinuation"}]},"_chembl":{"chemblId":"CHEMBL2106195","moleculeType":"Small molecule","molecularWeight":"236.75"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Dexmedetomidine binds with high selectivity to alpha-2 adrenergic receptors, particularly in the locus coeruleus and other brainstem regions, leading to decreased norepinephrine release and reduced neuronal firing. This results in a unique sedative state characterized by maintained airway reflexes and the ability to be aroused, along with analgesic and anxiolytic effects. The drug produces dose-dependent sedation without significant respiratory depression, making it suitable for procedural sedation and ICU sedation.","oneSentence":"Dexmedetomidine is a selective alpha-2 adrenergic receptor agonist that produces sedation, analgesia, and anxiolysis by activating presynaptic and postsynaptic alpha-2 receptors in the central nervous system.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:44:28.790Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Sedation of intubated and mechanically ventilated patients in intensive care settings"},{"name":"Procedural sedation for diagnostic and therapeutic procedures"},{"name":"Perioperative anxiolysis and analgesia"}]},"trialDetails":[{"nctId":"NCT04751812","phase":"NA","title":"Venous Cannulation Pain to Guide Choice of Anesthetic Method","status":"COMPLETED","sponsor":"Region Halland","startDate":"2022-03-01","conditions":"Pain, Postoperative, Pain Prediction, Laparoscopic Surgery","enrollment":270},{"nctId":"NCT03645603","phase":"PHASE2","title":"Efficacy and Safety of Dexmedetomidine During Weaning From Analgesia and Sedation in PICU (TIP-15-01)","status":"TERMINATED","sponsor":"IRCCS Azienda Ospedaliero-Universitaria di Bologna","startDate":"2018-08-30","conditions":"Withdrawal Syndrome","enrollment":45},{"nctId":"NCT02111421","phase":"PHASE4","title":"Postpartum Women's Dexmedetomidine Sedation","status":"COMPLETED","sponsor":"Guangzhou General Hospital of Guangzhou Military Command","startDate":"2015-06","conditions":"Cesarean Section","enrollment":60},{"nctId":"NCT02099253","phase":"PHASE4","title":"The Influence of Age on Dexmedetomidine Pharmacodynamic","status":"COMPLETED","sponsor":"Guangzhou General Hospital of Guangzhou Military Command","startDate":"2014-03","conditions":"Spinal Anesthesia","enrollment":82}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Dexmedetomidine 01","genericName":"Dexmedetomidine 01","companyName":"Guangzhou General Hospital of Guangzhou Military Command","companyId":"guangzhou-general-hospital-of-guangzhou-military-command","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Dexmedetomidine is a selective alpha-2 adrenergic receptor agonist that produces sedation, analgesia, and anxiolysis by activating presynaptic and postsynaptic alpha-2 receptors in the central nervous system. Used for Sedation of intubated and mechanically ventilated patients in intensive care settings, Procedural sedation for diagnostic and therapeutic procedures, Perioperative anxiolysis and analgesia.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}