{"id":"dexmedetomidine-0-5-g-kg","safety":{"commonSideEffects":[{"rate":"10-20","effect":"Hypotension"},{"rate":"5-15","effect":"Bradycardia"},{"rate":"5-10","effect":"Dry mouth"},{"rate":"5-10","effect":"Hypertension (transient, initial)"},{"rate":"5","effect":"Dizziness"}]},"_chembl":{"chemblId":"CHEMBL2106195","moleculeType":"Small molecule","molecularWeight":"236.75"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Dexmedetomidine binds with high selectivity to alpha-2 adrenergic receptors, particularly in the locus coeruleus and other brainstem regions, leading to decreased norepinephrine release and reduced neuronal firing. This results in a unique sedative state characterized by maintained airway reflexes and the ability to be aroused, along with analgesic and anxiolytic effects. The drug is commonly used for sedation in perioperative and intensive care settings.","oneSentence":"Dexmedetomidine is a selective alpha-2 adrenergic receptor agonist that produces sedation, analgesia, and anxiolysis by activating presynaptic and postsynaptic alpha-2 receptors in the central nervous system.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:32:33.378Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Sedation in perioperative and intensive care unit settings"},{"name":"Analgesia and anxiolysis in procedural sedation"}]},"trialDetails":[{"nctId":"NCT07264556","phase":"NA","title":"Effect of OFA, OSA Versus Opioid-based Anesthesia on NETs and Cancer Cell Malignancy After Colorectal Cancer Surgery","status":"RECRUITING","sponsor":"Fudan University","startDate":"2025-11-01","conditions":"Colorectal Cancer, Opioid-free Anesthesia, NETs","enrollment":90},{"nctId":"NCT07204106","phase":"NA","title":"Efficacy Study of Dexmedetomidine Nasal Spray Combined With Propofol for Deep Sedation in ERCP","status":"COMPLETED","sponsor":"Shiyou Wei","startDate":"2025-10-02","conditions":"Dexmedetomidine Induced Sedation, Nasal Administration, Sprays","enrollment":180},{"nctId":"NCT07179913","phase":"PHASE4","title":"The Improvement of Low-dose Esketamine on Postoperative Depression in Patients Undergoing Bariatric Surgery With Preoperative Depression","status":"NOT_YET_RECRUITING","sponsor":"The First Hospital of Jilin University","startDate":"2025-09-10","conditions":"Depressed, Bariatric Surgery","enrollment":40},{"nctId":"NCT04635098","phase":"NA","title":"DexmedetOmidine Complement Treats Chronic insOmnia and Improves Circadian Rhythm (DOCTOR)","status":"COMPLETED","sponsor":"Ruijin Hospital","startDate":"2021-05-14","conditions":"Chronic Insomnia","enrollment":64},{"nctId":"NCT06735443","phase":"PHASE2, PHASE3","title":"Comparative Efficacy & Safety of Dexmedetomidine vs Tramadol in Paeds Hernioraphy. A Caudal Anaesthesia Approach","status":"COMPLETED","sponsor":"Sahiwal medical college sahiwal","startDate":"2021-03-06","conditions":"Hemodynamic Stability, Post Operative Pain, Inguinal Hernia Repair","enrollment":60},{"nctId":"NCT03809442","phase":"PHASE4","title":"Analgesic Efficacy of Ropivacaine Alone or in Combination With Adjuvants on Post-operative Analgesia Following Video-Assisted Thoracoscopic Surgery.","status":"COMPLETED","sponsor":"Aga Khan University","startDate":"2019-06-25","conditions":"Postoperative Analgesia","enrollment":116},{"nctId":"NCT05769530","phase":"PHASE4","title":"Advanced Analgesia on the Quality of Recovery After General Anesthesia in Elderly Patients","status":"UNKNOWN","sponsor":"Lili Jia","startDate":"2023-05-01","conditions":"General Anesthetics，Emergence Agitation","enrollment":360},{"nctId":"NCT03207100","phase":"NA","title":"Analgesia-first Minimal Sedation for Spontaneous Intracerebral Hemorrhage Early Antihypertensive Treatment","status":"COMPLETED","sponsor":"Hong Yang","startDate":"2017-12-06","conditions":"Early Systolic Blood Pressure Control Rate, Hematoma Growth, Blood Pressure Variability","enrollment":338},{"nctId":"NCT03770130","phase":"EARLY_PHASE1","title":"Dexmedetomidine and Liver Transplantation","status":"COMPLETED","sponsor":"RenJi Hospital","startDate":"2019-01-14","conditions":"Dexmedetomidine, Liver Transplantation, Allograft Function, Survival","enrollment":330},{"nctId":"NCT04385602","phase":"PHASE2, PHASE3","title":"Effect of Intratracheal Dexmedetomidine Administration on Recovery From General Anesthesia in Pediatrics Undergoing Lower Abdominal Surgery:","status":"COMPLETED","sponsor":"Assiut University","startDate":"2020-06-01","conditions":"Intratracheal, Dexmedetomidine","enrollment":60},{"nctId":"NCT05631028","phase":"NA","title":"95% Effective Dose(ED95) of Remimazolam During Dexmedetomidine Pretreatment","status":"COMPLETED","sponsor":"Shiyou Wei","startDate":"2022-12-01","conditions":"Lung Cancer, Anesthesia Induction","enrollment":115},{"nctId":"NCT05661227","phase":"NA","title":"Mechanism of Cardiac and Cerebral Function Injury Caused by Intraoperative Limb Ischemia-reperfusion","status":"UNKNOWN","sponsor":"Hebei Medical University Third Hospital","startDate":"2023-01-01","conditions":"Ischemic Reperfusion Injury","enrollment":120},{"nctId":"NCT05567523","phase":"PHASE4","title":"Safety Study of Dexmedetomidine in Elderly Under General Anesthesia","status":"COMPLETED","sponsor":"Zhenjiang First People's Hospital","startDate":"2019-06-01","conditions":"Hip Fractures, Hip Disease","enrollment":200},{"nctId":"NCT04923737","phase":"NA","title":"Immunomodulatory Effects of Dexmedetomidine Infusion","status":"UNKNOWN","sponsor":"Alexandria University","startDate":"2022-01-01","conditions":"Major Abdominal Surgery","enrollment":100},{"nctId":"NCT04730375","phase":"PHASE2","title":"Evaluation of the Effect of Different Doses Dexmedetomidine Infusion on Lung Mechanics and Oxygenation in Obese Patients","status":"COMPLETED","sponsor":"National Cancer Institute, Egypt","startDate":"2021-01-30","conditions":"Obesity; Drug","enrollment":70},{"nctId":"NCT04397406","phase":"PHASE4","title":"Dexmedetomidine or Fentanyl as Additives to Epidural Levobupivacaine in Painless Labor","status":"COMPLETED","sponsor":"Tanta University","startDate":"2020-07-01","conditions":"Epidural Analgesia, Painless Labor, Dexmedetomidine","enrollment":90},{"nctId":"NCT03760809","phase":"PHASE4","title":"Dexmedetomidine Combined With Hydromorphone in Tonsillectomy and Adenoidectomy","status":"COMPLETED","sponsor":"Eye & ENT Hospital of Fudan University","startDate":"2019-01-04","conditions":"Agitated; State, Acute Reaction to Stress","enrollment":130},{"nctId":"NCT03639896","phase":"PHASE4","title":"Endothelial Injury Mechanism in Elderly Patients Undergoing Major Surgery","status":"COMPLETED","sponsor":"The First Affiliated Hospital of Anhui Medical University","startDate":"2019-07-01","conditions":"Endothelial Dysfunction, Blood Brain Barrier Defect, Postoperative Cognitive Dysfunction","enrollment":464},{"nctId":"NCT03788538","phase":"NA","title":"Effects of Dexmedetomidine on Modulation of Perioperative Blood Glucose and Related Hormones","status":"COMPLETED","sponsor":"Zhuan Zhang","startDate":"2017-11-01","conditions":"Dexmedetomidine, Blood Glucose","enrollment":75},{"nctId":"NCT04276545","phase":"PHASE3","title":"Dexmedetomidine Improves the Surgical Field and Postoperative Recovery of Nasal Endoscopic Surgery","status":"COMPLETED","sponsor":"Eye & ENT Hospital of Fudan University","startDate":"2018-01-01","conditions":"Dexmedetomidine, Bleeding, Surgical Field","enrollment":118},{"nctId":"NCT03477994","phase":"NA","title":"Efficacy of Dexmedetomidine Versus Clonidine to Control Delirium in Patients Undergoing CABG","status":"COMPLETED","sponsor":"Ain Shams University","startDate":"2018-12-01","conditions":"Delirium on Emergence","enrollment":147},{"nctId":"NCT03102359","phase":"PHASE2","title":"Brain Protection Effect of Selective Head Cooling and Dexmedetomidine in Patients Undergoing Liver Transplantation","status":"UNKNOWN","sponsor":"Huazhong University of Science and Technology","startDate":"2017-04-05","conditions":"Liver Transplant; Complications","enrollment":100},{"nctId":"NCT03524950","phase":"PHASE3","title":"Effect of Dexmedetomidine on Stress Study of Pituitrin in Laparoscopic Hysteromyoma Surgery","status":"UNKNOWN","sponsor":"Beijing Anzhen Hospital","startDate":"2018-06-01","conditions":"Hysteromyoma","enrollment":90},{"nctId":"NCT02275182","phase":"PHASE4","title":"Impact of Dexmedetomidine on the Post-Operative Cognition Dysfunction(POCD) in Geriatric Patients","status":"COMPLETED","sponsor":"The First Affiliated Hospital of Anhui Medical University","startDate":"2014-10","conditions":"Postoperative Confusion, Delirium","enrollment":864},{"nctId":"NCT03337581","phase":"PHASE4","title":"Pharmacodynamics and Pharmacokinetics of Dexmedetomidine in Pediatric","status":"UNKNOWN","sponsor":"Chinese Medical Association","startDate":"2017-10-20","conditions":"Pediatrics, Dexmedetomidine, Pharmacodynamics","enrollment":187},{"nctId":"NCT02479581","phase":"PHASE2","title":"The Safety and Efficacy of the Enhanced Recovery After Surgery(ERAS)Applied on Cardiac Surgery With Cardiopulmonary Bypass","status":"COMPLETED","sponsor":"Xiangya Hospital of Central South University","startDate":"2015-07","conditions":"Valvular Heart Disease","enrollment":226},{"nctId":"NCT03135795","phase":"PHASE4","title":"The Epigenetic Modification in OPRM1 on Postoperative Analgesia and Side Effect Induced by Sufentanil","status":"UNKNOWN","sponsor":"Huazhong University of Science and Technology","startDate":"2017-02-06","conditions":"Epigenetics","enrollment":100},{"nctId":"NCT02528513","phase":"PHASE4","title":"Midazolam Used Alone or Sequential Use of Midazolam and Propofol/Dexmedetomidine in Mechanically Ventilated Patients","status":"UNKNOWN","sponsor":"West China Hospital","startDate":"2015-12","conditions":"Mechanical Ventilation, Complication, Delirium","enrollment":240},{"nctId":"NCT02727712","phase":"PHASE4","title":"Studies of Application of Combined General Anesthesia and Bilateral TPVB in OPCABG","status":"UNKNOWN","sponsor":"Xiangya Hospital of Central South University","startDate":"2016-04","conditions":"Coronary Heart Disease","enrollment":60},{"nctId":"NCT02619513","phase":"PHASE4","title":"Effects of Dexmedetomidine Used in Continuous Thoracic Paravertebral Blocks","status":"COMPLETED","sponsor":"Weifeng Tu","startDate":"2014-12","conditions":"Post-thoracotomy Pain Syndrome","enrollment":60},{"nctId":"NCT02296073","phase":"PHASE4","title":"The Efficacy and the Safety of Dexmedetomidine Sedation on the Pediatric Intensive Unit(PICU) Patients.","status":"UNKNOWN","sponsor":"Anhui Provincial Children's Hospital","startDate":"2014-12","conditions":"Failed Conscious Sedation During Procedure","enrollment":120},{"nctId":"NCT02134093","phase":"PHASE4","title":"Effects of Dexmedetomidine on Postoperative Cognitive Dysfunction During One-lung Ventilation in Elder Patients","status":"UNKNOWN","sponsor":"Tang-Du Hospital","startDate":"2014-07","conditions":"Postoperative Confusion","enrollment":120},{"nctId":"NCT02123355","phase":"PHASE4","title":"The Effect of Dexmedetomidine to Cognition of Geriatrics in Prolonged Surgery","status":"UNKNOWN","sponsor":"Shaanxi Provincial People's Hospital","startDate":"2014-08","conditions":"Cognitive Ability, General, Brain Injury","enrollment":80},{"nctId":"NCT01353456","phase":"PHASE3","title":"Multimodal Analgesic Using Morphine and COX-2 With or Without Dexmedetomidine for Colorectal Surgery","status":"COMPLETED","sponsor":"The University of Hong Kong","startDate":"2008-05","conditions":"Pain, Postoperative","enrollment":100},{"nctId":"NCT00815893","phase":"PHASE2, PHASE3","title":"The Feasibility of Dexmedetomidine for Awake Fiberoptic Nasal Intubation","status":"UNKNOWN","sponsor":"Kaohsiung Medical University Chung-Ho Memorial Hospital","startDate":"2008-08","conditions":"Awake Fiberoptic Nasal Intubation","enrollment":60}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":10,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Dexmedetomidine Hydrochloride Injection"],"phase":"marketed","status":"active","brandName":"Dexmedetomidine 0.5μg／kg","genericName":"Dexmedetomidine 0.5μg／kg","companyName":"Eye & ENT Hospital of Fudan University","companyId":"eye-ent-hospital-of-fudan-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Dexmedetomidine is a selective alpha-2 adrenergic receptor agonist that produces sedation, analgesia, and anxiolysis by activating presynaptic and postsynaptic alpha-2 receptors in the central nervous system. Used for Sedation in perioperative and intensive care unit settings, Analgesia and anxiolysis in procedural sedation.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}