{"id":"dexlansoprazole-mr","safety":{"commonSideEffects":[{"rate":"12-15","effect":"Headache"},{"rate":"5-10","effect":"Diarrhea"},{"rate":"5-8","effect":"Abdominal pain"},{"rate":"4-7","effect":"Nausea"},{"rate":"3-5","effect":"Upper respiratory tract infection"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Dexlansoprazole is the active R-enantiomer of lansoprazole, a proton pump inhibitor (PPI). It binds to and inactivates the proton pump (H+/K+-ATPase) on the secretory surface of gastric parietal cells, reducing both basal and stimulated gastric acid production. The modified-release (MR) formulation provides dual-peak plasma concentrations to extend acid suppression throughout the day.","oneSentence":"Dexlansoprazole is a proton pump inhibitor that suppresses gastric acid secretion by irreversibly blocking the H+/K+-ATPase enzyme in parietal cells.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:09:18.145Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Gastroesophageal reflux disease (GERD)"},{"name":"Healing of erosive esophagitis"},{"name":"Maintenance of healed erosive esophagitis"}]},"trialDetails":[{"nctId":"NCT02646332","phase":"NA","title":"Comparing the Efficacy of Reverse Hybrid Therapy and Concomitant Therapy","status":"COMPLETED","sponsor":"Kaohsiung Veterans General Hospital.","startDate":"2015-12","conditions":"Helicobacter Pylori Infection","enrollment":248},{"nctId":"NCT04311541","phase":"","title":"A Study of Dexlansoprazole Modified Release (MR) in Gastroesophageal Reflux Disease 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molecule","firstApprovalDate":"","aiSummary":"Dexlansoprazole is a proton pump inhibitor that suppresses gastric acid secretion by irreversibly blocking the H+/K+-ATPase enzyme in parietal cells. Used for Gastroesophageal reflux disease (GERD), Healing of erosive esophagitis, Maintenance of healed erosive esophagitis.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}