{"id":"dexketoprofen-vitamin-b","safety":{"commonSideEffects":[{"rate":"10-20","effect":"Gastrointestinal upset (nausea, dyspepsia)"},{"rate":"5-15","effect":"Abdominal pain"},{"rate":"5-10","effect":"Headache"},{"rate":"3-8","effect":"Dizziness"},{"rate":"1-5","effect":"Gastric ulceration (with chronic use)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Dexketoprofen is the active S-enantiomer of ketoprofen, a nonsteroidal anti-inflammatory drug (NSAID) that blocks COX-1 and COX-2 enzymes, thereby reducing pain, inflammation, and fever. The addition of vitamin B (likely B-complex vitamins) may support nerve function and potentially enhance the analgesic effect through nutritional supplementation, making this a combination product targeting pain management.","oneSentence":"Dexketoprofen inhibits cyclooxygenase (COX) enzymes to reduce prostaglandin synthesis and inflammation, while vitamin B provides nutritional support and may enhance analgesic efficacy.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:09:18.119Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute and chronic pain conditions"},{"name":"Inflammatory conditions (arthritis, musculoskeletal pain)"}]},"trialDetails":[{"nctId":"NCT05001555","phase":"PHASE3","title":"Efficacy and Safety of Dexketoprofen/Vitamin B Vs Dexketoprofen for Post-traumatic Cervical Sprain Grade I-II","status":"COMPLETED","sponsor":"Laboratorios Silanes S.A. de C.V.","startDate":"2021-11-23","conditions":"Acute Low Back Pain","enrollment":174},{"nctId":"NCT05027126","phase":"PHASE1","title":"Comparison of Bioavailability of Dexketoprofen-Vit B vs Dexketoprofen, in Healthy Subjects, Under Fasting Conditions","status":"COMPLETED","sponsor":"Laboratorios Silanes S.A. de C.V.","startDate":"2019-02-28","conditions":"Healthy","enrollment":36}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["D/VitB"],"phase":"phase_3","status":"active","brandName":"Dexketoprofen/Vitamin B","genericName":"Dexketoprofen/Vitamin B","companyName":"Laboratorios Silanes S.A. de C.V.","companyId":"laboratorios-silanes-s-a-de-c-v","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Dexketoprofen inhibits cyclooxygenase (COX) enzymes to reduce prostaglandin synthesis and inflammation, while vitamin B provides nutritional support and may enhance analgesic efficacy. Used for Acute and chronic pain conditions, Inflammatory conditions (arthritis, musculoskeletal pain).","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}