{"id":"dexketoprofen-trometamol-thiocolchicoside","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal upset (nausea, dyspepsia)"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Abdominal pain"}]},"_chembl":{"chemblId":"CHEMBL213907","moleculeType":"Small molecule","molecularWeight":"563.63"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Dexketoprofen trometamol is the active S-enantiomer of ketoprofen, a nonsteroidal anti-inflammatory drug that inhibits cyclooxygenase (COX) enzymes to reduce prostaglandin synthesis and inflammation. Thiocolchicoside is a semi-synthetic derivative of colchicine that acts as a muscle relaxant by stabilizing microtubules and modulating GABA receptors, reducing muscle spasm and pain transmission. The combination targets both inflammatory pain and muscle tension.","oneSentence":"Dexketoprofen reduces pain and inflammation via COX inhibition, while thiocolchicoside relaxes muscles by modulating neuromuscular transmission and reducing spasticity.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:32:31.589Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute musculoskeletal pain with muscle spasm"},{"name":"Back pain with muscle tension"},{"name":"Inflammatory pain conditions"}]},"trialDetails":[{"nctId":"NCT05529290","phase":"PHASE4","title":"Evaluation of the Efficacy of Different Drugs in the Treatment of the Pain in Patients With Temporomandibular Disorder","status":"COMPLETED","sponsor":"Yuzuncu Yil University","startDate":"2019-07-16","conditions":"Temporomandibular Disorder","enrollment":200}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":2,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Dexketoprofen Trometamol + Thiocolchicoside","genericName":"Dexketoprofen Trometamol + Thiocolchicoside","companyName":"Yuzuncu Yil University","companyId":"yuzuncu-yil-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Dexketoprofen reduces pain and inflammation via COX inhibition, while thiocolchicoside relaxes muscles by modulating neuromuscular transmission and reducing spasticity. Used for Acute musculoskeletal pain with muscle spasm, Back pain with muscle tension, Inflammatory pain conditions.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}