{"id":"dexketoprofen-trometamol-paracetamol","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal upset"},{"rate":null,"effect":"Dyspepsia"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Headache"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Dexketoprofen trometamol is the active S-enantiomer of ketoprofen, a nonsteroidal anti-inflammatory drug (NSAID) that blocks COX-1 and COX-2 enzymes, thereby reducing inflammation, pain, and fever. Paracetamol (acetaminophen) complements this action through distinct mechanisms involving central inhibition of prostaglandin synthesis and modulation of pain perception. The combination provides enhanced analgesic and anti-inflammatory effects for acute pain management.","oneSentence":"Dexketoprofen inhibits cyclooxygenase (COX) enzymes to reduce prostaglandin synthesis, while paracetamol acts as an analgesic and antipyretic through central nervous system pathways.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:32:35.939Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute pain management"},{"name":"Postoperative pain"},{"name":"Musculoskeletal pain"}]},"trialDetails":[{"nctId":"NCT06878014","phase":"PHASE4","title":"Comparing the Safety and Effectiveness of Different Doses of Morphine Administered in Spinal Anethesia for Pain Relief After Hip Replacement Surgery","status":"RECRUITING","sponsor":"Medical University of Silesia","startDate":"2025-03-04","conditions":"Analgesics, Opioid, Anesthesia, Spinal, Total Hip Replacement","enrollment":120},{"nctId":"NCT06210126","phase":"NA","title":"Pectointercostal Fascial Plane Block Chronic Pain Sternotomy","status":"COMPLETED","sponsor":"Konya Meram State Hospital","startDate":"2024-01-18","conditions":"Chronic Pain","enrollment":50},{"nctId":"NCT06916234","phase":"PHASE4","title":"Evaluation of the Analgesic Efficacy of the Combination of Dexketoprofen + Paracetamol and the Combination of Naproxen Sodium + Codeine in Patients With Acute Dental Pain","status":"COMPLETED","sponsor":"ibrahim doğru","startDate":"2023-01-10","conditions":"Acute Dental Pain","enrollment":100},{"nctId":"NCT04894864","phase":"PHASE4","title":"Opioid Free Anesthesia-Analgesia Strategy and Surgical Stress in Elective Open Abdominal Aortic Aneurysm Repair","status":"RECRUITING","sponsor":"University of Crete","startDate":"2020-10-08","conditions":"Elective Surgical Procedures, Postoperative Pain, Anesthesia","enrollment":40},{"nctId":"NCT06222320","phase":"PHASE2, PHASE3","title":"Kinesiotaping Method for Rib Fractures","status":"COMPLETED","sponsor":"Kastamonu University","startDate":"2024-01-24","conditions":"Rib Fractures, Pain, Chest","enrollment":34},{"nctId":"NCT05602493","phase":"PHASE3","title":"A Randomized Control Trial Phase (IIIa) Unicentric, Placebo Controlled, Double-Blinded Efficacy and Safety of Topical Alendronic Acid on Alveolar Bone Remodeling After Tooth Extraction","status":"ACTIVE_NOT_RECRUITING","sponsor":"Xeolas Pharmaceuticals Limited","startDate":"2022-11-22","conditions":"Bone Loss, Alveolar","enrollment":60},{"nctId":"NCT06563271","phase":"PHASE4","title":"Approach to Ankle Sprains in the Emergency Department","status":"COMPLETED","sponsor":"Ankara Etlik City Hospital","startDate":"2023-12-01","conditions":"Ankle Sprains","enrollment":150},{"nctId":"NCT06558916","phase":"PHASE4","title":"Comparison of the Analgesic Efficacy of Dexketoprofen Trometamol, Meperidine, and Paracetamol in Renal Colic","status":"COMPLETED","sponsor":"Ismail Tekin","startDate":"2015-10","conditions":"Analgesia, Renal Colic","enrollment":90},{"nctId":"NCT05591105","phase":"","title":"The Postoperative Lidocaine and Ketamine Effects on Morphine Requirement in Bariatric Surgery","status":"COMPLETED","sponsor":"Tiva Group","startDate":"2023-06-15","conditions":"Pharmacological Action, Post Operative Pain, Opioid Use","enrollment":64},{"nctId":"NCT05125796","phase":"NA","title":"Analgesic Use for Pain Relief in Scorpion Sting","status":"COMPLETED","sponsor":"Adiyaman University Research Hospital","startDate":"2020-09-01","conditions":"Scorpion Stings","enrollment":106},{"nctId":"NCT05529290","phase":"PHASE4","title":"Evaluation of the Efficacy of Different Drugs in the Treatment of the Pain in Patients With Temporomandibular Disorder","status":"COMPLETED","sponsor":"Yuzuncu Yil University","startDate":"2019-07-16","conditions":"Temporomandibular Disorder","enrollment":200},{"nctId":"NCT05172739","phase":"PHASE4","title":"Opioid Free Anaesthesia-Analgesia Strategy on Surgical Stress and Immunomodulation in Elective VATS-Lobectomy for NSCLC","status":"RECRUITING","sponsor":"University of Crete","startDate":"2021-10-01","conditions":"Systemic Inflammatory Response Syndrome, Postoperative Pain, Acute, Postoperative Pain, Chronic","enrollment":70},{"nctId":"NCT04847024","phase":"NA","title":"Parecoxib vs. Dexketoprofen for the Management of Pain After Cesarean Section.","status":"COMPLETED","sponsor":"Saint Thomas Hospital, Panama","startDate":"2019-07-01","conditions":"Caesarean Section; Pain","enrollment":380},{"nctId":"NCT02777970","phase":"PHASE4","title":"Tramadol Hydrochloride and Dexketoprofen Trometamol for the Oral Treatment of Moderate to Severe Acute Pain Following Removal of Impacted Lower Third Molar","status":"COMPLETED","sponsor":"Menarini Group","startDate":"2016-04","conditions":"Acute Pain","enrollment":654},{"nctId":"NCT04609254","phase":"PHASE4","title":"Paracetamol, Dexketoprofen and Ibuprofen In Non-Traumatic Acute Low Back Pain","status":"COMPLETED","sponsor":"Pamukkale University","startDate":"2018-12-15","conditions":"Low Back Pain, Mechanical","enrollment":210},{"nctId":"NCT04372264","phase":"PHASE4","title":"Intravenous Paracetamol, Dexketoprofen and Ibuprofen in the Treatment of Acute Migraine Attack Headache","status":"UNKNOWN","sponsor":"Pamukkale University","startDate":"2018-10-15","conditions":"Headache, Migraine","enrollment":210},{"nctId":"NCT04313374","phase":"PHASE4","title":"Integrated Pulmonary Index and Opioid Based Patient Controlled Analgesia","status":"COMPLETED","sponsor":"Istanbul University","startDate":"2016-08-01","conditions":"Brain Tumors","enrollment":90},{"nctId":"NCT04200885","phase":"PHASE4","title":"Is Therapeutic Elastic Bandage As Effective As Corticosteroids Following Third Molar Surgery?","status":"COMPLETED","sponsor":"Tokat Gaziosmanpasa University","startDate":"2019-05-02","conditions":"Third Molar Surgery","enrollment":52},{"nctId":"NCT04178109","phase":"PHASE2","title":"Oral Use of Dexketoprofen/Tramadol for Acute Postoperative Pain in Total Hip Replacement With a Direct Anterior Approach.","status":"COMPLETED","sponsor":"KAT General Hospital","startDate":"2019-01-10","conditions":"Postoperative Pain, Pain, Acute","enrollment":226},{"nctId":"NCT02018601","phase":"PHASE4","title":"Intercostal Nerves Block in the Midaxillary Line Versus Paravertebral Block for no Reconstructive Breast Surgery","status":"UNKNOWN","sponsor":"Paula Diéguez García","startDate":"2013-09","conditions":"no Reconstructive Breast Surgery","enrollment":120},{"nctId":"NCT03865004","phase":"PHASE4","title":"Combination Trial of Intravenous Paracetamol - Morphine for Treating Acute Renal Colic in Emergency Setting: An Optimum Treatment","status":"COMPLETED","sponsor":"Akdeniz University","startDate":"2015-10-17","conditions":"Renal Colic","enrollment":136},{"nctId":"NCT03830398","phase":"PHASE4","title":"Comparison of Drugs on Headache Treatment After ECT Treatment","status":"UNKNOWN","sponsor":"Mustafa Kemal University","startDate":"2018-11-20","conditions":"Mental Disorders","enrollment":225},{"nctId":"NCT03768882","phase":"PHASE4","title":"Comparison of the Efficacy of Intravenous Dexketoprofen and Paracetamol in the Treatment of Sore Throat","status":"COMPLETED","sponsor":"Pamukkale University","startDate":"2017-12-01","conditions":"Sore Throat","enrollment":200},{"nctId":"NCT03697746","phase":"NA","title":"Comparison of Dexketoprofen, Paracetamol and Ibuprofen in the Treatment of Primary Dysmenorrhea","status":"UNKNOWN","sponsor":"Pamukkale University","startDate":"2018-10-01","conditions":"Dysmenorrhea","enrollment":300},{"nctId":"NCT03428503","phase":"PHASE4","title":"Comparison of Efficacy of Intravenous Paracetamol and Dexketoprofen for Acute Traumatic Musculoskeletal Pain","status":"COMPLETED","sponsor":"Pamukkale University","startDate":"2015-12","conditions":"Musculoskeletal Pain","enrollment":200},{"nctId":"NCT03122314","phase":"PHASE4","title":"Comparison of Efficacy of Intravenous Paracetamol and Dexketoprofen for Acute Nontraumatic Musculoskeletal Pain","status":"COMPLETED","sponsor":"Pamukkale University","startDate":"2015-08","conditions":"Musculoskeletal Pain","enrollment":200},{"nctId":"NCT01638962","phase":"NA","title":"The Effect on Knee Joint Loads of Analgesic Use Compared With Exercise in Patients With Knee Osteoarthritis - An RCT","status":"COMPLETED","sponsor":"University of Southern Denmark","startDate":"2012-08","conditions":"Osteoarthritis, Knee","enrollment":93},{"nctId":"NCT02602197","phase":"PHASE3","title":"Intravenous Paracetamol Compared Dexketoprofen for Postoperative Analgesia After Septoplasty","status":"UNKNOWN","sponsor":"Baskent University","startDate":"2013-08","conditions":"Postoperative Pain","enrollment":2},{"nctId":"NCT02373514","phase":"PHASE4","title":"IV Paracetamol Versus IV Dexketoprofen in Dysmenorrhea","status":"UNKNOWN","sponsor":"Akdeniz University","startDate":"2015-01","conditions":"Dysmenorrhea","enrollment":100},{"nctId":"NCT01993589","phase":"NA","title":"Effect of Paracetamol, Dexketoprofen Trometamol, Lidocaine Spray, Pethidine and Diclofenac Sodium Application for Pain Relief During Fractional Curettage","status":"COMPLETED","sponsor":"Kayseri Education and Research Hospital","startDate":"2012-11","conditions":"Pain and Curettage","enrollment":144},{"nctId":"NCT01947205","phase":"NA","title":"Pain and Suction Curettage","status":"COMPLETED","sponsor":"Gökhan Açmaz","startDate":"2012-11","conditions":"Curettage, Analgesia, Paracervical Block","enrollment":111},{"nctId":"NCT01730326","phase":"PHASE4","title":"Intravenous Dexketoprofen and Paracetamol in the Treatment of Headache Caused by Acute Migraine Attack","status":"COMPLETED","sponsor":"Pamukkale University","startDate":"2012-03","conditions":"Acute Migraine","enrollment":200},{"nctId":"NCT01422291","phase":"PHASE4","title":"IV Paracetamol, Dexketoprofen or Morphine for the Treatment of Low Back Pain","status":"COMPLETED","sponsor":"Pamukkale University","startDate":"2011-01","conditions":"Low Back Pain","enrollment":120}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":36,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Dexketoprofen Trometamol + Paracetamol","genericName":"Dexketoprofen Trometamol + Paracetamol","companyName":"Yuzuncu Yil University","companyId":"yuzuncu-yil-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Dexketoprofen inhibits cyclooxygenase (COX) enzymes to reduce prostaglandin synthesis, while paracetamol acts as an analgesic and antipyretic through central nervous system pathways. Used for Acute pain management, Postoperative pain, Musculoskeletal pain.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}