{"id":"dexchlorpheniramine-pseudoephedrine-guaifenesin","safety":{"commonSideEffects":[{"rate":null,"effect":"Drowsiness"},{"rate":null,"effect":"Dry mouth"},{"rate":null,"effect":"Nervousness or insomnia"},{"rate":null,"effect":"Tachycardia"},{"rate":null,"effect":"Headache"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Dexchlorpheniramine is a first-generation H1-receptor antagonist that blocks histamine-mediated allergic responses. Pseudoephedrine is an alpha-adrenergic agonist that causes vasoconstriction in nasal blood vessels to reduce congestion. Guaifenesin is an expectorant that thins respiratory secretions to facilitate clearance of mucus.","oneSentence":"This combination drug reduces allergy symptoms via antihistamine action, nasal congestion via sympathomimetic decongestant, and cough via expectorant action.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:09:18.216Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Allergic rhinitis with nasal congestion and cough"},{"name":"Common cold with allergic symptoms and congestion"}]},"trialDetails":[{"nctId":"NCT01085721","phase":"PHASE3","title":"Comparison Between Dexchlorpheniramine and Dexchlorpheniramine/Pseudoephedrine/Guaifenesin in Respiratory Infections","status":"UNKNOWN","sponsor":"Mantecorp Industria Quimica e Farmaceutica Ltd.","startDate":"","conditions":"Viral Infections of the Upper Respiratory Tract","enrollment":170}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Dexchlorpheniramine, pseudoephedrine, guaifenesin","genericName":"Dexchlorpheniramine, pseudoephedrine, guaifenesin","companyName":"Mantecorp Industria Quimica e Farmaceutica Ltd.","companyId":"mantecorp-industria-quimica-e-farmaceutica-ltd","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This combination drug reduces allergy symptoms via antihistamine action, nasal congestion via sympathomimetic decongestant, and cough via expectorant action. Used for Allergic rhinitis with nasal congestion and cough, Common cold with allergic symptoms and congestion.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}