{"id":"dexchlorpheniramine-1-lotion","safety":{"commonSideEffects":[{"rate":null,"effect":"Local skin irritation"},{"rate":null,"effect":"Contact dermatitis"},{"rate":null,"effect":"Drowsiness (if systemically absorbed)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"As a potent H1-receptor antagonist, dexchlorpheniramine competitively inhibits histamine at H1 receptors on mast cells, endothelial cells, and other tissues, thereby reducing itching, erythema, and other allergic manifestations. The lotion formulation allows topical delivery to affected skin areas, providing localized antihistamine and anti-inflammatory effects with reduced systemic absorption compared to oral formulations.","oneSentence":"Dexchlorpheniramine is a first-generation H1-receptor antagonist that blocks histamine binding to reduce allergic and inflammatory responses in the skin.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:09:18.137Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Pruritus and allergic dermatitis (topical treatment)"},{"name":"Urticaria and other allergic skin conditions"}]},"trialDetails":[{"nctId":"NCT01085851","phase":"PHASE3","title":"Non-inferiority Clinical Trial of Dexchlorpheniramine (Cream Versus Lotion) in the Relief of Sunburn Related Symptoms","status":"UNKNOWN","sponsor":"Mantecorp Industria Quimica e Farmaceutica Ltd.","startDate":"","conditions":"Sunburn","enrollment":30},{"nctId":"NCT00995397","phase":"PHASE3","title":"Non-inferiority Clinical Trial of Dexchlorpheniramine (Cream Versus Lotion) in the Relief of Insect Bite Related Symptoms","status":"UNKNOWN","sponsor":"Mantecorp Industria Quimica e Farmaceutica Ltd.","startDate":"","conditions":"Insect Bites","enrollment":30}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Dexchlorpheniramine 1% lotion","genericName":"Dexchlorpheniramine 1% lotion","companyName":"Mantecorp Industria Quimica e Farmaceutica Ltd.","companyId":"mantecorp-industria-quimica-e-farmaceutica-ltd","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Dexchlorpheniramine is a first-generation H1-receptor antagonist that blocks histamine binding to reduce allergic and inflammatory responses in the skin. Used for Pruritus and allergic dermatitis (topical treatment), Urticaria and other allergic skin conditions.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}