{"id":"dexchlorpheniramine-1-gel","safety":{"commonSideEffects":[{"rate":null,"effect":"Local skin irritation or burning"},{"rate":null,"effect":"Drowsiness (if systemic absorption occurs)"},{"rate":null,"effect":"Contact dermatitis"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"As a first-generation antihistamine, dexchlorpheniramine competitively antagonizes H1 histamine receptors, preventing histamine from binding and triggering allergic symptoms such as itching, urticaria, and inflammation. When formulated as a 1% gel, it provides localized topical delivery to affected skin areas, reducing systemic absorption and side effects while targeting cutaneous allergic reactions directly.","oneSentence":"Dexchlorpheniramine is a selective H1-receptor antagonist that blocks histamine-mediated allergic and inflammatory responses in topical form.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:45:50.015Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Allergic dermatitis and pruritus (topical)"},{"name":"Urticaria and other allergic skin conditions (topical)"}]},"trialDetails":[{"nctId":"NCT02441894","phase":"PHASE4","title":"Combination of Cabazitaxel With Prednisolone With Primary Prophylaxis With PEG-G-CSF in Treatment of Patients With Prostate Cancer","status":"COMPLETED","sponsor":"Sanofi","startDate":"2015-04","conditions":"Prostate Cancer","enrollment":21},{"nctId":"NCT01237925","phase":"PHASE3","title":"Non-inferiority Clinical Trial of Dexchlorpheniramine (Cream Versus Gel) in the Relief of Sunburn Related Symptoms","status":"UNKNOWN","sponsor":"Mantecorp Industria Quimica e Farmaceutica Ltd.","startDate":"","conditions":"Sunburn","enrollment":124},{"nctId":"NCT01233934","phase":"PHASE3","title":"Comparative Study of Two Forms of Topical Dexchlorpheniramine Maleate (Cream Versus Gel) for Insect Bites","status":"UNKNOWN","sponsor":"Mantecorp Industria Quimica e Farmaceutica Ltd.","startDate":"2011-02","conditions":"Insect Bites","enrollment":90}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Dexchlorpheniramine 1% gel","genericName":"Dexchlorpheniramine 1% gel","companyName":"Mantecorp Industria Quimica e Farmaceutica Ltd.","companyId":"mantecorp-industria-quimica-e-farmaceutica-ltd","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Dexchlorpheniramine is a selective H1-receptor antagonist that blocks histamine-mediated allergic and inflammatory responses in topical form. Used for Allergic dermatitis and pruritus (topical), Urticaria and other allergic skin conditions (topical).","enrichmentLevel":3,"visitCount":2,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}