{"id":"dexamethasone-tobramycin-netilimicin","safety":{"commonSideEffects":[{"rate":null,"effect":"Local irritation or burning"},{"rate":null,"effect":"Allergic reaction"},{"rate":null,"effect":"Ototoxicity (with systemic absorption)"},{"rate":null,"effect":"Nephrotoxicity (with systemic absorption)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Dexamethasone suppresses inflammatory and immune responses by binding glucocorticoid receptors, while tobramycin and netilimicin are aminoglycoside antibiotics that inhibit bacterial protein synthesis by binding to the 30S ribosomal subunit. This combination is typically used topically or in localized settings to address both infection and inflammation simultaneously.","oneSentence":"This is a combination of a corticosteroid (dexamethasone) and two aminoglycoside antibiotics (tobramycin and netilimicin) that reduces inflammation and provides broad-spectrum bacterial coverage.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:32:32.949Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Bacterial infections with concurrent inflammation (likely ophthalmic or otic use)"}]},"trialDetails":[{"nctId":"NCT06404541","phase":"PHASE4","title":"A Comparative Study Between Preservative With Benzalkonium Chloride vs Preservative Free Eye Drops on the Ocular Surface","status":"ACTIVE_NOT_RECRUITING","sponsor":"Kasr El Aini Hospital","startDate":"2024-01-10","conditions":"Ocular Surface Disease, Dry Eye Syndromes","enrollment":60}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Dexamethasone, tobramycin, netilimicin","genericName":"Dexamethasone, tobramycin, netilimicin","companyName":"Kasr El Aini Hospital","companyId":"kasr-el-aini-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This is a combination of a corticosteroid (dexamethasone) and two aminoglycoside antibiotics (tobramycin and netilimicin) that reduces inflammation and provides broad-spectrum bacterial coverage. Used for Bacterial infections with concurrent inflammation (likely ophthalmic or otic use).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}