{"id":"dexamethasone-palmitate","rwe":[{"pmid":"41809412","year":"2026","title":"A Case of a Novel Perforin Gene Variant in Severe Familial Hemophagocytic Lymphohistiocytosis Type 2 (FHL2).","finding":"","journal":"Case reports in hematology","studyType":"Clinical Study"},{"pmid":"41406884","year":"2026","title":"Dexamethasone palmitate: A promising intratympanic treatment option for severe sudden hearing loss.","finding":"","journal":"American journal of otolaryngology","studyType":"Clinical Study"},{"pmid":"41357139","year":"2025","title":"Dexamethasone palmitate-loaded sHDL nanodiscs: Enhanced efficacy and safety in allergic conjunctivitis.","finding":"","journal":"Journal of pharmaceutical analysis","studyType":"Clinical Study"},{"pmid":"41320217","year":"2025","title":"INDEX study: intravenous dexamethasone palmitate for prophylaxis of postoperative nausea and vomiting: a study protocol for a randomised controlled study.","finding":"","journal":"BMJ open","studyType":"Clinical Study"},{"pmid":"41155972","year":"2025","title":"Drug-Integrating Amphiphilic Nano-Assemblies: 3. 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Limethason is a synthetic version of that key, which binds to the lock and triggers the same calming effect, helping to reduce swelling and pain in conditions like arthritis or asthma.","oneSentence":"Limethason works by binding to the glucocorticoid receptor, activating it and triggering a cascade of downstream effects that reduce inflammation and immune response.","technicalDetail":"Limethason (dexamethasone palmitate) is a prodrug that is metabolized to dexamethasone, a potent glucocorticoid receptor agonist that exerts its effects through the transcriptional regulation of genes involved in inflammation and immune response."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/828","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=dexamethasone%20palmitate","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=dexamethasone palmitate","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T10:36:19.686322","biosimilars":[],"competitors":[{"drugName":"alclometasone dipropionate","drugSlug":"alclometasone-dipropionate","fdaApproval":"1982-12-14","genericCount":3,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"amcinonide","drugSlug":"amcinonide","fdaApproval":"1979-10-18","genericCount":4,"patentStatus":"Off-patent — generic 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dipropionate","approvalYear":"1982","relationship":"same-target"},{"drugId":"amcinonide","brandName":"amcinonide","genericName":"amcinonide","approvalYear":"1979","relationship":"same-target"},{"drugId":"auranofin","brandName":"auranofin","genericName":"auranofin","approvalYear":"1985","relationship":"same-target"},{"drugId":"beclometasone-dipropionate","brandName":"beclometasone dipropionate","genericName":"beclometasone dipropionate","approvalYear":"1976","relationship":"same-target"},{"drugId":"betamethasone","brandName":"betamethasone","genericName":"betamethasone","approvalYear":"1961","relationship":"same-target"},{"drugId":"betamethasone-acetate","brandName":"betamethasone acetate","genericName":"betamethasone acetate","approvalYear":"1965","relationship":"same-target"},{"drugId":"betamethasone-benzoate","brandName":"betamethasone benzoate","genericName":"betamethasone 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Pain","status":"NOT_YET_RECRUITING","sponsor":"Beijing Tiantan Hospital","startDate":"2026-02-02","conditions":["Pain, Postoperative","Dexamethasone Palmitate"],"enrollment":446,"completionDate":"2026-12-30"},{"nctId":"NCT06981754","phase":"NA","title":"Dexamethasone Palmitate for PONV After Minimally Invasive Endoscopic Surgery","status":"RECRUITING","sponsor":"Beijing Tiantan Hospital","startDate":"2025-06-17","conditions":["Postoperative Nausea and Vomiting","Dexamethasone Palmitate","Minimally Invasive Endoscopic Procedures"],"enrollment":588,"completionDate":"2026-12-31"},{"nctId":"NCT06997419","phase":"NA","title":"Dexamethasone Palmitate for PONV After Open Surgery","status":"RECRUITING","sponsor":"Beijing Tiantan Hospital","startDate":"2025-07-01","conditions":["Postoperative Nausea and Vomiting","Dexamethasone Palmitate","Open Surgery"],"enrollment":500,"completionDate":"2026-12-31"},{"nctId":"NCT06988124","phase":"NA","title":"Dexamethasone Palmitate for PONV After Craniotomy","status":"RECRUITING","sponsor":"Beijing Tiantan Hospital","startDate":"2025-06-25","conditions":["Postoperative Nausea and Vomiting"],"enrollment":500,"completionDate":"2027-06-01"},{"nctId":"NCT05920967","phase":"NA","title":"PANDORA: Paravertebral AdjuNctive DexamethasOne Palmitate Reducing Chronic Pain After Caridiac Surgery","status":"ACTIVE_NOT_RECRUITING","sponsor":"Xijing Hospital","startDate":"2023-07-11","conditions":["Chronic Postoperative Pain"],"enrollment":562,"completionDate":"2025-12-30"},{"nctId":"NCT05693467","phase":"PHASE4","title":"Preemptive Co-infiltration of Dexamethasone Palmitate With Ropivacaine for Postoperative Pain in Major Spinal Surgery","status":"COMPLETED","sponsor":"Beijing Tiantan Hospital","startDate":"2023-03-01","conditions":["Pain, Postoperative"],"enrollment":124,"completionDate":"2023-09-30"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{},"crossReferences":{"MMSL":"4552","NDDF":"002174","UNII":"601XWN7060","CHEBI":"CHEBI:31471","VANDF":"4017922","INN_ID":"816","RXNORM":"3264","UMLSCUI":"C5222049","ChEMBL_ID":"CHEMBL384467","KEGG_DRUG":"D01615","DRUGBANK_ID":"DB01234","PDB_CHEM_ID":" DEX","PUBCHEM_CID":"63044","SNOMEDCT_US":"372584003","MESH_DESCRIPTOR_UI":"D003907","MESH_SUPPLEMENTAL_RECORD_UI":"C035081"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":79,"therapeuticAreas":["Immunology"],"biosimilarFilings":[],"recentPublications":[{"date":"2026","pmid":"41809412","title":"A Case of a Novel Perforin Gene Variant in Severe Familial Hemophagocytic Lymphohistiocytosis Type 2 (FHL2).","journal":"Case reports in hematology"},{"date":"2026 Jan-Feb","pmid":"41406884","title":"Dexamethasone palmitate: A promising intratympanic treatment option for severe sudden hearing loss.","journal":"American journal of otolaryngology"},{"date":"2025 Nov","pmid":"41357139","title":"Dexamethasone palmitate-loaded sHDL nanodiscs: Enhanced efficacy and safety in allergic conjunctivitis.","journal":"Journal of pharmaceutical analysis"},{"date":"2025 Nov 29","pmid":"41320217","title":"INDEX study: intravenous dexamethasone palmitate for prophylaxis of postoperative nausea and vomiting: a study protocol for a randomised controlled study.","journal":"BMJ open"},{"date":"2025 Oct 16","pmid":"41155972","title":"Drug-Integrating Amphiphilic Nano-Assemblies: 3. PEG-PPS/Palmitate Nanomicelles for Sustained and Localized Delivery of Dexamethasone in Cell and Tissue Transplantations.","journal":"Pharmaceutics"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"Limethason (dexamethasone palmitate) is a corticosteroid medication that targets the glucocorticoid receptor. It is a small molecule that works by binding to the receptor, mimicking the effects of the body's natural glucocorticoids. Limethason is used to treat various inflammatory conditions, but its commercial status and approved indications are unknown. As a corticosteroid, it carries key safety considerations, including potential side effects such as immunosuppression and increased risk of infections. Further research is needed to determine its full scope of use and safety profile.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":4,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":true,"score":2}}