{"id":"dexamethasone-dipropionate","rwe":[{"pmid":"24640598","year":"2014","title":"The effect of storage time on the release profile of dexamethasone dipropionate from admixtures of steroid and heparinoid ointments.","finding":"","journal":"Die Pharmazie","studyType":"Clinical Study"},{"pmid":"24206105","year":"2013","title":"Dexamethasone dipropionate loaded nanoparticles of α-elastin-g-PLGA for potential treatment of restenosis.","finding":"","journal":"Molecular pharmaceutics","studyType":"Clinical Study"},{"pmid":"22293488","year":"2012","title":"Release profiles of dexamethasone dipropionate from admixtures of steroid and heparinoid ointments prepared by different mixing methods.","finding":"","journal":"Chemical & pharmaceutical bulletin","studyType":"Clinical Study"}],"tags":[{"label":"Corticosteroid","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"},{"label":"Anti-Inflammatory Agents","category":"pharmacology"},{"label":"Antiemetics","category":"pharmacology"},{"label":"Antineoplastic Agents","category":"pharmacology"},{"label":"Antineoplastic Agents, Hormonal","category":"pharmacology"},{"label":"Central Nervous System Agents","category":"pharmacology"},{"label":"Gastrointestinal Agents","category":"pharmacology"},{"label":"Glucocorticoids","category":"pharmacology"},{"label":"Hormones","category":"pharmacology"},{"label":"Peripheral Nervous System Agents","category":"pharmacology"}],"phase":"unknown","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"methaderm","offLabel":[],"synonyms":["dexamethasone propionate","dexamethasone dipropionate","methaderm"],"timeline":[],"approvals":[],"brandName":"Methaderm","ecosystem":[],"mechanism":{"moaClass":"Corticosteroid Hormone Receptor Agonists","modality":"Small Molecule","drugClass":"Corticosteroid","explanation":"Imagine your body's immune system as a fire alarm that sounds when it detects an intruder. Corticosteroids like Methaderm are like a fire alarm silencer that reduces the alarm's sensitivity, allowing the body to reduce its inflammatory response and 'put out the fire'. This can help alleviate symptoms of conditions like arthritis or asthma.","oneSentence":"Methaderm works by binding to glucocorticoid receptors in the body, triggering a response that reduces inflammation and suppresses the immune system.","technicalDetail":"Methaderm exerts its effects by binding to glucocorticoid receptors in the cytosol, translocating to the nucleus, and inducing the expression of anti-inflammatory genes, while suppressing the expression of pro-inflammatory genes."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/827","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=dexamethasone%20dipropionate","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=dexamethasone dipropionate","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T10:36:14.812533","biosimilars":[],"competitors":[],"genericName":"dexamethasone dipropionate","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[{"nctId":"NCT02582177","phase":"PHASE3","title":"Effectiveness Study of Ketoconazole and Betamethasone to Treat Fungal Infection and Dermatophytosis","status":"COMPLETED","sponsor":"Ache Laboratorios Farmaceuticos S.A.","startDate":"2019-06-11","conditions":["Tinea"],"enrollment":125,"completionDate":"2020-03-24"},{"nctId":"NCT03279796","phase":"PHASE2","title":"Treatment of Tendon Disease Using Autologous Adipose-derived Mesenchymal Stem Cells","status":"UNKNOWN","sponsor":"Second Affiliated Hospital, School of Medicine, Zhejiang University","startDate":"2018-10-01","conditions":["Rotator Cuff Tear","Lateral Epicondylitis"],"enrollment":200,"completionDate":"2021-12-31"},{"nctId":"NCT03300531","phase":"PHASE2","title":"Impact of Autologous Pure Platelet-rich Plasma in the Treatment of Tendon Disease","status":"UNKNOWN","sponsor":"Second Affiliated Hospital, School of Medicine, Zhejiang University","startDate":"2017-12-01","conditions":["Rotator Cuff Tear","Lateral Epicondylitis","Achilles Tendinitis"],"enrollment":540,"completionDate":"2021-12-31"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"MMSL":"4552","NDDF":"002174","UNII":"K3UKR54YXW","CHEBI":"CHEBI:31470","VANDF":"4017922","INN_ID":"816","RXNORM":"3264","UMLSCUI":"C0245678","ChEMBL_ID":"CHEMBL1697788","KEGG_DRUG":"D01632","DRUGBANK_ID":"DB01234","PDB_CHEM_ID":" DEX","PUBCHEM_CID":"63049","SNOMEDCT_US":"372584003","MESH_DESCRIPTOR_UI":"D003907","MESH_SUPPLEMENTAL_RECORD_UI":"C059542"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":3,"therapeuticAreas":["Immunology"],"biosimilarFilings":[],"recentPublications":[{"date":"2014 Feb","pmid":"24640598","title":"The effect of storage time on the release profile of dexamethasone dipropionate from admixtures of steroid and heparinoid ointments.","journal":"Die Pharmazie"},{"date":"2013 Dec 2","pmid":"24206105","title":"Dexamethasone dipropionate loaded nanoparticles of α-elastin-g-PLGA for potential treatment of restenosis.","journal":"Molecular pharmaceutics"},{"date":"2012","pmid":"22293488","title":"Release profiles of dexamethasone dipropionate from admixtures of steroid and heparinoid ointments prepared by different mixing methods.","journal":"Chemical & pharmaceutical bulletin"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"Methaderm (dexamethasone dipropionate) is a corticosteroid small molecule medication. It is used to treat various inflammatory conditions, although specific approved indications are not provided. As a corticosteroid, Methaderm works by mimicking the effects of cortisol in the body, reducing inflammation and suppressing the immune system. The commercial status of Methaderm is unknown, and key safety considerations include potential side effects such as increased risk of infections and osteoporosis. Further information on its pharmacokinetics and commercial status is required.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":true,"score":2}}