{"id":"dexamethasone-azathioprine-pulse-therapy","safety":{"commonSideEffects":[{"rate":null,"effect":"Infection (opportunistic and bacterial)"},{"rate":null,"effect":"Hyperglycemia"},{"rate":null,"effect":"Hypertension"},{"rate":null,"effect":"Myelosuppression"},{"rate":null,"effect":"Gastrointestinal disturbance"},{"rate":null,"effect":"Osteoporosis"}]},"_chembl":{"chemblId":"CHEMBL1542","moleculeType":"Small molecule","molecularWeight":"277.27"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Dexamethasone is a potent glucocorticoid that suppresses inflammatory cytokine production and immune cell activation. Azathioprine is a purine analog that inhibits lymphocyte proliferation by interfering with nucleotide synthesis. Pulse therapy involves high-dose intermittent administration to achieve rapid immunosuppression while potentially reducing cumulative toxicity compared to continuous dosing.","oneSentence":"This combination therapy uses dexamethasone (a corticosteroid) to suppress inflammation and azathioprine (an immunosuppressant) to inhibit T-cell proliferation, administered in pulse doses for rapid immune modulation.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:33:56.560Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Severe autoimmune diseases (e.g., lupus nephritis, vasculitis, severe rheumatoid arthritis)"},{"name":"Organ transplant rejection prophylaxis"}]},"trialDetails":[{"nctId":"NCT06846255","phase":"PHASE4","title":"Comparing DCP and DAP for Pemphigus Vulgaris","status":"COMPLETED","sponsor":"Jinnah Postgraduate Medical Centre","startDate":"2021-06-15","conditions":"Pemphigus Vulgaris","enrollment":66},{"nctId":"NCT05861297","phase":"PHASE4","title":"Immune Thrombocytopenia Management in Adults","status":"UNKNOWN","sponsor":"Nahda University","startDate":"2020-05-05","conditions":"Immune Thrombocytopenia Purpura","enrollment":467},{"nctId":"NCT00656656","phase":"PHASE2","title":"Immunoadsorption, Dexamethasone Pulse Therapy and Rituximab for Pemphigus","status":"COMPLETED","sponsor":"University of Luebeck","startDate":"2008-01","conditions":"Pemphigus","enrollment":23}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Injection Decadron , Tablet Imuran Pulse therapy"],"phase":"marketed","status":"active","brandName":"Dexamethasone Azathioprine Pulse therapy","genericName":"Dexamethasone Azathioprine Pulse therapy","companyName":"Jinnah Postgraduate Medical Centre","companyId":"jinnah-postgraduate-medical-centre","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This combination therapy uses dexamethasone (a corticosteroid) to suppress inflammation and azathioprine (an immunosuppressant) to inhibit T-cell proliferation, administered in pulse doses for rapid immune modulation. Used for Severe autoimmune diseases (e.g., lupus nephritis, vasculitis, severe rheumatoid arthritis), Organ transplant rejection prophylaxis.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}