{"id":"destin-maximum-strength-40-zinc","safety":{"commonSideEffects":[{"rate":null,"effect":"Local skin irritation"},{"rate":null,"effect":"Allergic contact dermatitis"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Zinc oxide is a topical protectant that creates an occlusive barrier on the skin, preventing contact between irritants (urine, feces) and the epidermis. It also has mild astringent and antiseptic properties that support skin integrity and reduce inflammation in diaper dermatitis. The 40% concentration provides enhanced protective coverage for affected areas.","oneSentence":"Zinc oxide forms a physical barrier on the skin surface to protect against moisture and irritants, reducing diaper rash and promoting skin healing.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:44:20.857Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Diaper rash prevention and treatment"},{"name":"Minor skin irritation and chafing"}]},"trialDetails":[{"nctId":"NCT02716415","phase":"PHASE4","title":"Trial Comparing Calmoseptine Ointment and Desitin Diaper Rash Paste in Diaper Dermatitis in Neonates and Infants","status":"COMPLETED","sponsor":"University of the Philippines","startDate":"2015-03","conditions":"Diaper Dermatitis","enrollment":319},{"nctId":"NCT02080247","phase":"PHASE3","title":"Treatment of Incontinence Associated Dermatitis in Older Children and Adults","status":"COMPLETED","sponsor":"University of the Philippines","startDate":"2012-12","conditions":"Incontinence Associated Dermatitis","enrollment":142}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Destin"],"phase":"marketed","status":"active","brandName":"Destin Maximum Strength 40% Zinc","genericName":"Destin Maximum Strength 40% Zinc","companyName":"University of the Philippines","companyId":"university-of-the-philippines","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Zinc oxide forms a physical barrier on the skin surface to protect against moisture and irritants, reducing diaper rash and promoting skin healing. Used for Diaper rash prevention and treatment, Minor skin irritation and chafing.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}