{"id":"desoxycortone","rwe":[{"pmid":"41109644","year":"2025","title":"Brain-derived exosomes from aged mice accelerate cognitive decline in repeated mild traumatic brain injury by activating neuronal Tnfrsf25.","finding":"","journal":"Experimental gerontology","studyType":"Clinical Study"},{"pmid":"40998882","year":"2025","title":"Characterization of the effects of oxymatrine on myocardial hypertrophy in spontaneously hypertensive rats through transcriptomics and metabolomics.","finding":"","journal":"Scientific reports","studyType":"Clinical Study"},{"pmid":"38720776","year":"2024","title":"Shenling Baizhu San ameliorates non-alcoholic fatty liver disease in mice by modulating gut microbiota and metabolites.","finding":"","journal":"Frontiers in pharmacology","studyType":"Clinical Study"},{"pmid":"37202726","year":"2023","title":"Alterations of the gut microbiome and metabolic profile in CVB3-induced mice acute viral myocarditis.","finding":"","journal":"BMC microbiology","studyType":"Clinical Study"},{"pmid":"36257488","year":"2022","title":"Protective effect of biogenic selenium nanoparticles against diquat-induced acute toxicity via regulation of gut microbiota and its metabolites.","finding":"","journal":"Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association","studyType":"Clinical Study"}],"tags":[{"label":"desoxycortone","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Mineralocorticoid receptor","category":"target"},{"label":"NR3C2","category":"gene"},{"label":"HTR2A","category":"gene"},{"label":"HTR2C","category":"gene"},{"label":"H02AA03","category":"atc"},{"label":"Active","category":"status"},{"label":"Hormones","category":"pharmacology"},{"label":"Mineralocorticoids","category":"pharmacology"}],"phase":"unknown","safety":{"drugInteractions":[{"url":"/drug/aripiprazole","drug":"aripiprazole","action":"Monitor closely","effect":"May interact with Aripiprazole, Desoxycorticosterone","source":"DrugCentral","drugSlug":"aripiprazole"},{"url":"/drug/quetiapine","drug":"quetiapine","action":"Monitor closely","effect":"May interact with Desoxycorticosterone, Quetiapine Fumarate","source":"DrugCentral","drugSlug":"quetiapine"},{"url":"/drug/risperidone","drug":"risperidone","action":"Monitor closely","effect":"May interact with Desoxycorticosterone, Risperidone","source":"DrugCentral","drugSlug":"risperidone"}]},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"cortexone","offLabel":[],"synonyms":["desoxycorticosterone","cortexone","deoxycorticosterone","deoxycortone","desoxycortone"],"timeline":[],"approvals":[],"brandName":"Cortexone","ecosystem":[],"mechanism":{"target":"Corticosteroid-binding globulin, Sex hormone-binding globulin, 5-hydroxytryptamine receptor 2A","targets":[{"gene":"NR3C2","source":"DrugCentral","target":"Mineralocorticoid receptor","protein":"Mineralocorticoid receptor"},{"gene":"HTR2A","source":"DrugCentral","target":"5-hydroxytryptamine receptor 2A","protein":"5-hydroxytryptamine receptor 2A"},{"gene":"HTR2C","source":"DrugCentral","target":"5-hydroxytryptamine receptor 2C","protein":"5-hydroxytryptamine receptor 2C"},{"gene":"SERPINA6","source":"DrugCentral","target":"Corticosteroid-binding globulin","protein":"Corticosteroid-binding globulin"},{"gene":"HTR2B","source":"DrugCentral","target":"5-hydroxytryptamine receptor 2B","protein":"5-hydroxytryptamine receptor 2B"},{"gene":"SHBG","source":"DrugCentral","target":"Sex hormone-binding globulin","protein":"Sex hormone-binding globulin"},{"gene":"NR3C1","source":"DrugCentral","target":"Glucocorticoid receptor","protein":"Glucocorticoid receptor"}],"modality":"Small Molecule","drugClass":"desoxycortone","explanation":"Imagine your body has locks on the cells that control how much water and salt you have. The mineralocorticoid receptor is like a key that unlocks these locks, allowing the right amount of water and salt to enter the body. Cortexone is like a fake key that fits into these locks, telling the cells to behave in a certain way.","oneSentence":"Cortexone works by binding to the mineralocorticoid receptor, mimicking the effects of naturally occurring corticosteroids.","technicalDetail":"Cortexone exerts its effects by binding to the mineralocorticoid receptor (MR), a nuclear receptor that regulates gene expression involved in electrolyte and water balance, blood pressure, and other physiological processes."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/820","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=desoxycortone","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=desoxycortone","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T10:29:36.948611","biosimilars":[],"competitors":[{"drugName":"fludrocortisone acetate","drugSlug":"fludrocortisone-acetate","fdaApproval":"1955-08-18","genericCount":7,"patentStatus":"Off-patent — generic available","relationship":"same-class"}],"dataSources":[{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"genericName":"desoxycortone","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"fludrocortisone-acetate","brandName":"fludrocortisone acetate","genericName":"fludrocortisone acetate","approvalYear":"1955","relationship":"same-class"}],"trialDetails":[{"nctId":"NCT06801249","phase":"PHASE4","title":"Effect of Metyrapone on Cardiovascular Risk Factors in Patients With Adrenal Incidentalomas and Cushing's Syndrome","status":"RECRUITING","sponsor":"IRCCS Azienda Ospedaliero-Universitaria di Bologna","startDate":"2021-02-23","conditions":["Adrenal Incidentalomas","Cushing Syndrome"],"enrollment":50,"completionDate":"2025-02-17"},{"nctId":"NCT00570271","phase":"NA","title":"Placebo Effects on Blood Pressure","status":"UNKNOWN","sponsor":"Charite University, Berlin, Germany","startDate":"2007-04","conditions":["Blood Pressure"],"enrollment":90,"completionDate":"2008-02"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{},"crossReferences":{"NUI":"N0000147802","NDDF":"002207","UNII":"40GP35YQ49","VUID":"4019710","CHEBI":"CHEBI:16973","VANDF":"4019710","INN_ID":"387","RXNORM":"3256","UMLSCUI":"C0011710","ChEMBL_ID":"CHEMBL1200542","KEGG_DRUG":"D07792","DRUGBANK_ID":"DB15972","PDB_CHEM_ID":" 1CA","PUBCHEM_CID":"6166","SNOMEDCT_US":"1336006","IUPHAR_LIGAND_ID":"2871","MESH_DESCRIPTOR_UI":"D003900"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":14,"therapeuticAreas":["Hematology"],"atcClassification":{"source":"DrugCentral","atcCode":"H02AA03","allCodes":["H02AA03"]},"biosimilarFilings":[],"recentPublications":[{"date":"2025 Nov","pmid":"41109644","title":"Brain-derived exosomes from aged mice accelerate cognitive decline in repeated mild traumatic brain injury by activating neuronal Tnfrsf25.","journal":"Experimental gerontology"},{"date":"2025 Sep 25","pmid":"40998882","title":"Characterization of the effects of oxymatrine on myocardial hypertrophy in spontaneously hypertensive rats through transcriptomics and metabolomics.","journal":"Scientific reports"},{"date":"2024","pmid":"38720776","title":"Shenling Baizhu San ameliorates non-alcoholic fatty liver disease in mice by modulating gut microbiota and metabolites.","journal":"Frontiers in pharmacology"},{"date":"2023 May 18","pmid":"37202726","title":"Alterations of the gut microbiome and metabolic profile in CVB3-induced mice acute viral myocarditis.","journal":"BMC microbiology"},{"date":"2022 Dec","pmid":"36257488","title":"Protective effect of biogenic selenium nanoparticles against diquat-induced acute toxicity via regulation of gut microbiota and its metabolites.","journal":"Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"Cortexone, also known as desoxycortone, is a small molecule that targets the mineralocorticoid receptor. It is a synthetic corticosteroid, but its exact commercial status and approved indications are unknown. As a desoxycortone, it is classified as a synthetic corticosteroid, but further information on its development, approval, and manufacturing is not available. Further research is needed to understand its pharmacokinetics and safety profile. Its exact mechanism of action and clinical applications are unclear.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":true,"score":2}}