{"id":"desonide-0-1-cream","safety":{"commonSideEffects":[{"rate":"10-20%","effect":"Skin irritation"},{"rate":"1-5%","effect":"Allergic contact dermatitis"},{"rate":"1-5%","effect":"Hypersensitivity reactions"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"Desonide works by binding to glucocorticoid receptors in the skin, which leads to a decrease in the production of pro-inflammatory cytokines and other mediators. This results in reduced inflammation and itching. The exact mechanism of action is not fully understood, but it is thought to involve the inhibition of phospholipase A2 and the subsequent reduction in the production of leukotrienes and prostaglandins.","oneSentence":"Desonide is a topical corticosteroid that reduces inflammation by inhibiting the production of pro-inflammatory mediators.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:09:07.149Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Eczema"},{"name":"Psoriasis"}]},"trialDetails":[{"nctId":"NCT03758365","phase":"PHASE1","title":"Evaluation of the Vasoconstriction Properties of MC2-01 Cream","status":"COMPLETED","sponsor":"MC2 Therapeutics","startDate":"2018-11-05","conditions":"Vasoconstriction","enrollment":36},{"nctId":"NCT01467362","phase":"PHASE3","title":"Efficacy Emollient on Xerosis in Children With Atopic Dermatitis","status":"COMPLETED","sponsor":"Pierre Fabre Medicament","startDate":"2011-11","conditions":"Atopic Dermatitis","enrollment":251}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Locapred"],"phase":"phase_3","status":"active","brandName":"desonide 0.1% cream","genericName":"desonide 0.1% cream","companyName":"Pierre Fabre Medicament","companyId":"pierre-fabre-medicament","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Desonide is a topical corticosteroid that reduces inflammation by inhibiting the production of pro-inflammatory mediators. Used for Eczema, Psoriasis.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}