{"id":"desomorphine","rwe":[{"pmid":"40443421","year":"2025","title":"Necrotic Lesions Associated with Desomorphine (\"Krokodil\") Drug Abuse: a Systematic Review.","finding":"","journal":"Journal of oral & maxillofacial research","studyType":"Clinical Study"},{"pmid":"40141378","year":"2025","title":"Morphinan Alkaloids and Their Transformations: A Historical Perspective of a Century of Opioid Research in Hungary.","finding":"","journal":"International journal of molecular sciences","studyType":"Clinical Study"},{"pmid":"39785722","year":"2025","title":"Street Pharmacology: Toxico-Dermatology of Injection Drug Use.","finding":"","journal":"Journal of clinical pharmacology","studyType":"Clinical Study"},{"pmid":"38077704","year":"2023","title":"Krokodil-Associated Cutaneous Ulceration, Cardiac Arrhythmia and Thrombi.","finding":"","journal":"European journal of case reports in internal medicine","studyType":"Clinical Study"},{"pmid":"37232759","year":"2023","title":"Surgical Treatment in Patients with Toxic Phosphorus Osteonecrosis of Facial Skull Middle Zone.","finding":"","journal":"Dentistry journal","studyType":"Clinical Study"}],"tags":[{"label":"desomorphine","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"},{"label":"Analgesics","category":"pharmacology"},{"label":"Analgesics, Opioid","category":"pharmacology"},{"label":"Central Nervous System Agents","category":"pharmacology"},{"label":"Central Nervous System Depressants","category":"pharmacology"},{"label":"Narcotics","category":"pharmacology"},{"label":"Peripheral Nervous System Agents","category":"pharmacology"},{"label":"Sensory System Agents","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":["NCT00147355","NCT05752734","NCT06076759","NCT02622126","NCT01021696","NCT00354835","NCT04603638","NCT02258815","NCT00580489","NCT02929589","NCT02135055","NCT00268814","NCT01986283","NCT06691386","NCT00337792","NCT07037745","NCT04316871","NCT04284098","NCT07218549","NCT00715988","NCT04033094","NCT02479581","NCT05537623","NCT05560542","NCT01552863","NCT03387956","NCT03330340","NCT00743587","NCT02926976","NCT05304585","NCT01198132","NCT01549652","NCT00751478","NCT05582135","NCT02033707","NCT00802087","NCT02858310","NCT04788589","NCT01538706","NCT05262465","NCT01596673","NCT07466316","NCT01919034","NCT03105232","NCT00802308","NCT03080493","NCT00544947","NCT04766463","NCT06931639","NCT01549002"],"aliases":[],"patents":[],"pricing":[],"allNames":"morphine d","offLabel":[],"synonyms":["desomorphine","Deoxydihydromorphine D","dihydrodeoxymorphine","Dihydrodesoxymorphine D","dihydroepoxymorphine","Morphine D"],"timeline":[],"approvals":[],"brandName":"Morphine D","ecosystem":[],"mechanism":{"target":"Opioid receptor","modality":"Small Molecule","drugClass":"desomorphine","explanation":"Imagine your brain has special locks called opioid receptors. Desomorphine is a key that fits into these locks, sending a signal to your brain that says 'pain is gone.' This helps to reduce the sensation of pain, but it can also lead to dependence and addiction.","oneSentence":"Desomorphine works by binding to opioid receptors in the brain, mimicking the action of natural opioids to produce pain relief.","technicalDetail":"Desomorphine exerts its analgesic effects by binding to mu-opioid receptors (MOR) in the central nervous system, activating G-protein coupled signaling pathways that ultimately lead to the inhibition of pain transmission."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/3134","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=DESOMORPHINE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T10:35:13.696518","biosimilars":[],"competitors":[{"drugName":"alfentanil","drugSlug":"alfentanil","fdaApproval":"1986-12-29","genericCount":1,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"apomorphine","drugSlug":"apomorphine","fdaApproval":"2004-04-20","patentExpiry":"Jun 11, 2030","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"codeine","drugSlug":"codeine","fdaApproval":"1952-01-21","genericCount":1,"patentStatus":"Off-patent — generic 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Hungary.","journal":"International journal of molecular sciences"},{"date":"2025 May","pmid":"39785722","title":"Street Pharmacology: Toxico-Dermatology of Injection Drug Use.","journal":"Journal of clinical pharmacology"},{"date":"2023","pmid":"38077704","title":"Krokodil-Associated Cutaneous Ulceration, Cardiac Arrhythmia and Thrombi.","journal":"European journal of case reports in internal medicine"},{"date":"2023 Apr 23","pmid":"37232759","title":"Surgical Treatment in Patients with Toxic Phosphorus Osteonecrosis of Facial Skull Middle Zone.","journal":"Dentistry journal"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Morphine D, also known as desomorphine, is a synthetic opioid analgesic developed by Paul Jolles in 1932. It is a small molecule drug classified under the desomorphine drug class. Desomorphine is not FDA-approved for any indications and its commercial status is unknown. Key safety considerations include its potential for abuse and dependence. As a potent opioid, it works by binding to opioid receptors in the brain, providing pain relief.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":true,"score":2}}