{"id":"desogestrel-early-follicular-phase","safety":{"commonSideEffects":[{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Breast tenderness"},{"rate":null,"effect":"Breakthrough bleeding"},{"rate":null,"effect":"Mood changes"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Desogestrel is a third-generation synthetic progestin used in hormonal contraceptives. It works primarily by inhibiting the luteinizing hormone (LH) surge needed to trigger ovulation. Additionally, it increases cervical mucus viscosity to impede sperm penetration and alters the endometrium to reduce implantation likelihood. The early follicular phase formulation is part of a biphasic or multiphasic oral contraceptive regimen.","oneSentence":"Desogestrel is a progestin that prevents pregnancy by suppressing ovulation and altering cervical mucus and endometrial conditions.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:09:10.105Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Contraception (pregnancy prevention)"}]},"trialDetails":[{"nctId":"NCT03895099","phase":"PHASE3","title":"New Ovarian Stimulation With Random Start, Use of Progestin Protocol for Oocyte Donors","status":"COMPLETED","sponsor":"Centre Hospitalier Intercommunal Creteil","startDate":"2020-09-04","conditions":"Infertility","enrollment":110}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":14,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Desogestrel early follicular phase","genericName":"Desogestrel early follicular phase","companyName":"Centre Hospitalier Intercommunal Creteil","companyId":"centre-hospitalier-intercommunal-creteil","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Desogestrel is a progestin that prevents pregnancy by suppressing ovulation and altering cervical mucus and endometrial conditions. Used for Contraception (pregnancy prevention).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}