{"id":"deslorelin","rwe":[{"pmid":"41547312","year":"2026","title":"Elevated anti-müllerian hormone concentrations in blood serum of dogs with oligozoospermia or azoospermia.","finding":"","journal":"Domestic animal endocrinology","studyType":"Clinical Study"},{"pmid":"41349370","year":"2026","title":"Deslorelin influences canine epididymal gene expression of the androgen receptor and prostaglandin metabolism.","finding":"","journal":"Animal reproduction science","studyType":"Clinical Study"},{"pmid":"41255165","year":"2025","title":"Effectiveness of Deslorelin Implants in Suppressing Egg Production in a White-Naped Crane (Antigone vipio): A Case Study.","finding":"","journal":"Zoo biology","studyType":"Clinical Study"},{"pmid":"41112769","year":"2025","title":"Serum proteomic profiling during the periovulatory period identifies preliminary candidate biomarkers of oocyte maturation in deslorelin-induced ovulation in dogs.","finding":"","journal":"PeerJ","studyType":"Clinical Study"},{"pmid":"41065688","year":"2025","title":"DEVELOPMENT AND VALIDATION OF DESLORELIN ACETATE ASSAY AND A PILOT STUDY ON THE PHARMACOKINETICS OF DESLORELIN ACETATE IMPLANTS AND FECAL HORMONE MONITORING IN THE DOMESTIC GOAT (CAPRA HIRCUS).","finding":"","journal":"Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians","studyType":"Clinical Study"}],"tags":[{"label":"Peptide","category":"modality"},{"label":"Gonadotropin-releasing hormone receptor","category":"target"},{"label":"GNRHR","category":"gene"},{"label":"Active","category":"status"},{"label":"Enzyme Inhibitors","category":"pharmacology"}],"phase":"marketed","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"_sources":{"trials":{"url":"https://clinicaltrials.gov/search?intr=DESLORELIN","method":"api_direct","source":"ClinicalTrials.gov","rawText":"","confidence":1,"sourceType":"ctgov","retrievedAt":"2026-04-20T00:38:43.576158+00:00"},"regulatory.ca":{"url":"","method":"api_direct","source":"Health Canada DPD","rawText":"","confidence":1,"sourceType":"health_canada_dpd","retrievedAt":"2026-04-20T00:38:48.800105+00:00"},"publicationCount":{"url":"https://pubmed.ncbi.nlm.nih.gov/?term=DESLORELIN","method":"api_direct","source":"PubMed/NCBI","rawText":"","confidence":1,"sourceType":"pubmed","retrievedAt":"2026-04-20T00:38:49.135738+00:00"},"mechanism.target_chembl":{"url":"","method":"api_direct","source":"ChEMBL mechanism: Gonadotropin-releasing hormone receptor agonist","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T00:38:50.370736+00:00"},"crossReferences.chemblId":{"url":"https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL2357192/","method":"api_direct","source":"ChEMBL (EMBL-EBI)","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T00:38:49.856149+00:00"}},"allNames":["deslorelin","deslorelin acetate"],"offLabel":[],"synonyms":["deslorelin","deslorelin acetate"],"timeline":[],"aiSummary":"Deslorelin is a small molecule that targets the gonadotropin-releasing hormone receptor. It is used to treat conditions such as precocious puberty and certain types of cancer. The commercial status of deslorelin is patented, with the original developer being Zeneca (now part of AstraZeneca) and the current owner being a subsidiary of Zoetis. Key safety considerations include potential effects on hormone levels and reproductive function. Deslorelin works by binding to the gonadotropin-releasing hormone receptor, which regulates the release of hormones involved in reproductive processes.","approvals":[{"date":"","orphan":false,"company":"","regulator":"FDA"}],"ecosystem":[],"mechanism":{"target":"Gonadotropin-releasing hormone receptor","novelty":"First-in-class","targets":[{"gene":"GNRHR","source":"DrugCentral","target":"Gonadotropin-releasing hormone receptor","protein":"Gonadotropin-releasing hormone receptor"}],"modality":"Peptide","explanation":"","oneSentence":"","technicalDetail":"Deslorelin acts as a competitive antagonist at the gonadotropin-releasing hormone receptor, inhibiting the release of gonadotropin-releasing hormone and subsequently reducing the secretion of gonadotropins, such as luteinizing hormone and follicle-stimulating hormone."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/5673","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=DESLORELIN","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=DESLORELIN","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T10:28:37.476522","_validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T00:38:51.659308+00:00","fieldsConflicting":1,"overallConfidence":0.8},"biosimilars":[],"competitors":[{"drugName":"abarelix","drugSlug":"abarelix","fdaApproval":"2003-11-25","patentStatus":"Unknown","relationship":"same-target"},{"drugName":"cetrorelix","drugSlug":"cetrorelix","fdaApproval":"2000-08-11","genericCount":5,"patentStatus":"Off-patent — generic 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