{"id":"desloratadine-betamethasone-in-fixed-dose","safety":{"commonSideEffects":[{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Pharyngitis"},{"rate":null,"effect":"Somnolence"},{"rate":null,"effect":"Adrenal suppression (with prolonged corticosteroid use)"},{"rate":null,"effect":"Local irritation at application site"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Desloratadine is a selective H1-receptor antagonist that prevents histamine-mediated allergic reactions without significant central nervous system penetration. Betamethasone is a glucocorticoid that reduces inflammation by suppressing cytokine production and immune cell activation. The fixed combination targets both the acute histamine-driven symptoms and the underlying inflammatory cascade in allergic conditions.","oneSentence":"Desloratadine blocks histamine H1 receptors to reduce allergic symptoms, while betamethasone is a corticosteroid that suppresses inflammatory and immune responses.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:09:05.317Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Allergic rhinitis"},{"name":"Allergic dermatitis"},{"name":"Urticaria"}]},"trialDetails":[{"nctId":"NCT06916884","phase":"PHASE3","title":"Confirmatory Study on the Efficacy and Safety of the Fixed-dose Combination of Desloratadine/Betamethasone Versus Desloratadine","status":"RECRUITING","sponsor":"Laboratorios Silanes S.A. de C.V.","startDate":"2024-11-11","conditions":"Allergic Rhinitis","enrollment":70}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["DESLORA / BETA"],"phase":"phase_3","status":"active","brandName":"Desloratadine / Betamethasone in fixed dose","genericName":"Desloratadine / Betamethasone in fixed dose","companyName":"Laboratorios Silanes S.A. de C.V.","companyId":"laboratorios-silanes-s-a-de-c-v","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Desloratadine blocks histamine H1 receptors to reduce allergic symptoms, while betamethasone is a corticosteroid that suppresses inflammatory and immune responses. Used for Allergic rhinitis, Allergic dermatitis, Urticaria.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}