{"id":"deslanoside","rwe":[{"pmid":"41902440","year":"2026","title":"Possible Deslanoside-Induced Left Posterior Fascicular Ventricular Tachycardia: A Case Report.","finding":"","journal":"Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc","studyType":"Clinical Study"},{"pmid":"30725648","year":"2026","title":"Cardioactive Steroid Toxicity.","finding":"","journal":"","studyType":"Clinical Study"},{"pmid":"41689856","year":"2026","title":"Inhibitory effects and molecular interaction analysis of emergency cardiac drugs on human serum paraoxonase 1: an integrated in vitro and in silico approach.","finding":"","journal":"Archives of physiology and biochemistry","studyType":"Clinical Study"},{"pmid":"41656529","year":"2026","title":"Development and Validation of a UHPLC-MS/MS Method to Identify Interference from Qiliqiangxin Capsule and Deslanoside in Digoxin Therapeutic Drug Monitoring: A Comparison with Immunoassay.","finding":"","journal":"Therapeutic drug monitoring","studyType":"Clinical Study"},{"pmid":"41616397","year":"2026","title":"Magnetic C(18)-modified mesoporous silica as an efficient adsorbent for dispersive solid phase microextraction of cardiac glycosides in human plasma.","finding":"","journal":"Journal of chromatography. A","studyType":"Clinical Study"}],"tags":[{"label":"deslanoside","category":"class"},{"label":"Peptide","category":"modality"},{"label":"Sodium/potassium-transporting ATPase","category":"target"},{"label":"ATP1A1","category":"gene"},{"label":"ATP1A2","category":"gene"},{"label":"ATP1A3","category":"gene"},{"label":"C01AA07","category":"atc"},{"label":"Off-Patent","category":"patent"},{"label":"Active","category":"status"},{"label":"Novartis","category":"company"},{"label":"Anti-Arrhythmia Agents","category":"pharmacology"},{"label":"Cardiotonic Agents","category":"pharmacology"},{"label":"Cardiovascular Agents","category":"pharmacology"},{"label":"Enzyme Inhibitors","category":"pharmacology"},{"label":"Protective Agents","category":"pharmacology"}],"phase":"marketed","safety":{},"trials":[],"aliases":[],"company":"Novartis","patents":[],"pricing":[],"_sources":{"trials":{"url":"https://clinicaltrials.gov/search?intr=DESLANOSIDE","method":"api_direct","source":"ClinicalTrials.gov","rawText":"","confidence":1,"sourceType":"ctgov","retrievedAt":"2026-04-20T02:02:07.942840+00:00"},"regulatory.ca":{"url":"","method":"api_direct","source":"Health Canada DPD","rawText":"","confidence":1,"sourceType":"health_canada_dpd","retrievedAt":"2026-04-20T02:02:14.576412+00:00"},"publicationCount":{"url":"https://pubmed.ncbi.nlm.nih.gov/?term=DESLANOSIDE","method":"api_direct","source":"PubMed/NCBI","rawText":"","confidence":1,"sourceType":"pubmed","retrievedAt":"2026-04-20T02:02:15.219181+00:00"},"mechanism.target_chembl":{"url":"","method":"api_direct","source":"ChEMBL mechanism: Sodium/potassium-transporting ATPase inhibitor","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T02:02:16.290856+00:00"},"crossReferences.chemblId":{"url":"https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL1614/","method":"api_direct","source":"ChEMBL (EMBL-EBI)","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T02:02:15.951185+00:00"}},"allNames":"cedilanid d","offLabel":[],"synonyms":["deslanoside","Cedilanid D","Deacetylanatoside C","Deacetyllanatoside C","desace","Desacetyllanatoside C","Deslanatoside C","Deslanoside C","Purpurea glycoside C"],"timeline":[],"approvals":[{"date":"","orphan":false,"company":"NOVARTIS","regulator":"FDA"}],"brandName":"Cedilanid D","ecosystem":[],"mechanism":{"target":"Sodium/potassium-transporting ATPase","novelty":"First-in-class","targets":[{"gene":"ATP1A1","source":"DrugCentral","target":"Sodium/potassium-transporting ATPase","protein":"Sodium/potassium-transporting ATPase subunit alpha-1"},{"gene":"ATP1A2","source":"DrugCentral","target":"Sodium/potassium-transporting ATPase","protein":"Sodium/potassium-transporting ATPase subunit alpha-2"},{"gene":"ATP1A3","source":"DrugCentral","target":"Sodium/potassium-transporting ATPase","protein":"Sodium/potassium-transporting ATPase subunit alpha-3"},{"gene":"ATP1A4","source":"DrugCentral","target":"Sodium/potassium-transporting ATPase","protein":"Sodium/potassium-transporting ATPase subunit alpha-4"},{"gene":"ATP1B1","source":"DrugCentral","target":"Sodium/potassium-transporting ATPase","protein":"Sodium/potassium-transporting ATPase subunit beta-1"},{"gene":"ATP1B2","source":"DrugCentral","target":"Sodium/potassium-transporting ATPase","protein":"Sodium/potassium-transporting ATPase subunit beta-2"},{"gene":"ATP1B3","source":"DrugCentral","target":"Sodium/potassium-transporting ATPase","protein":"Sodium/potassium-transporting ATPase subunit beta-3"},{"gene":"FXYD2","source":"DrugCentral","target":"Sodium/potassium-transporting ATPase","protein":"Sodium/potassium-transporting ATPase subunit gamma"}],"modality":"Small Molecule","drugClass":"deslanoside","explanation":"","oneSentence":"","technicalDetail":"Deslanoside is a cardiac glycoside that inhibits the sodium/potassium-transporting ATPase (Na+/K+-ATPase) by binding to the enzyme's beta subunit, leading to an increase in intracellular sodium and a decrease in intracellular potassium, which in turn slows the heart rate and increases the force of contraction."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/813","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=DESLANOSIDE","fields":["publications"],"source":"PubMed/NCBI"},{"id":3,"url":"https://www.fda.gov/drugs/drug-approvals-and-databases/orange-book-data-files","fields":["patents","exclusivity","genericManufacturers"],"source":"FDA Orange Book"}],"_enrichedAt":"2026-03-30T10:28:32.824903","_validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T02:02:17.494208+00:00","fieldsConflicting":1,"overallConfidence":0.8},"biosimilars":[],"competitors":[{"drugName":"acetyldigitoxin","drugSlug":"acetyldigitoxin","fdaApproval":"1975-04-24","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"digitoxin","drugSlug":"digitoxin","fdaApproval":"","genericCount":1,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"digoxin","drugSlug":"digoxin","fdaApproval":"1975-10-24","genericCount":14,"patentStatus":"Off-patent — generic available","relationship":"same-class"}],"dataSources":[{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"genericName":"deslanoside","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"patentStatus":"Off-patent — no active Orange Book patents","relatedDrugs":[{"drugId":"acetyldigitoxin","brandName":"acetyldigitoxin","genericName":"acetyldigitoxin","approvalYear":"1975","relationship":"same-class"},{"drugId":"digitoxin","brandName":"digitoxin","genericName":"digitoxin","approvalYear":"","relationship":"same-class"},{"drugId":"digoxin","brandName":"digoxin","genericName":"digoxin","approvalYear":"1975","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{},"_patentsChecked":true,"crossReferences":{"NUI":"N0000147056","NDDF":"000595","UNII":"YGY317RK75","VUID":"4018753","CHEBI":"CHEBI:31468","VANDF":"4018753","INN_ID":"1581","RXNORM":"3248","UMLSCUI":"C0011689","chemblId":"CHEMBL1614","ChEMBL_ID":"CHEMBL1614","KEGG_DRUG":"D01240","DRUGBANK_ID":"DB01078","PUBCHEM_CID":"28620","SNOMEDCT_US":"16214005","IUPHAR_LIGAND_ID":"6806","MESH_DESCRIPTOR_UI":"D003892"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[{"period":"","companyName":"Novartis","relationship":"Original Developer"}],"publicationCount":91,"therapeuticAreas":["Cardiovascular"],"atcClassification":{"source":"DrugCentral","atcCode":"C01AA07","allCodes":["C01AA07"]},"biosimilarFilings":[],"originalDeveloper":"Novartis","recentPublications":[{"date":"2026 May","pmid":"41902440","title":"Possible Deslanoside-Induced Left Posterior Fascicular Ventricular Tachycardia: A Case Report.","journal":"Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc"},{"date":"2026 Jan","pmid":"30725648","title":"Cardioactive Steroid Toxicity.","journal":""},{"date":"2026 Feb 14","pmid":"41689856","title":"Inhibitory effects and molecular interaction analysis of emergency cardiac drugs on human serum paraoxonase 1: an integrated in vitro and in silico approach.","journal":"Archives of physiology and biochemistry"},{"date":"2026 Feb 9","pmid":"41656529","title":"Development and Validation of a UHPLC-MS/MS Method to Identify Interference from Qiliqiangxin Capsule and Deslanoside in Digoxin Therapeutic Drug Monitoring: A Comparison with Immunoassay.","journal":"Therapeutic drug monitoring"},{"date":"2026 Mar 29","pmid":"41616397","title":"Magnetic C(18)-modified mesoporous silica as an efficient adsorbent for dispersive solid phase microextraction of cardiac glycosides in human plasma.","journal":"Journal of chromatography. A"}],"companionDiagnostics":[],"genericManufacturers":0,"_genericFilersChecked":true,"genericManufacturerList":[],"status":"approved","companyName":"Novartis","companyId":"novartis","modality":"Small molecule","firstApprovalDate":"1982","aiSummary":"","enrichmentLevel":3,"visitCount":1,"regulatoryByCountry":[{"country_code":"US","regulator":"FDA","status":"approved","approval_date":null,"mah":"NOVARTIS","brand_name_local":null,"application_number":""},{"country_code":"CA","regulator":"Health Canada","status":"approved","approval_date":null,"mah":"","brand_name_local":"","application_number":""},{"country_code":"BR","regulator":"ANVISA","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"MX","regulator":"COFEPRIS","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"AR","regulator":"ANMAT","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"TR","regulator":"TITCK","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"IN","regulator":"CDSCO","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"TH","regulator":"FDA-TH","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"MY","regulator":"NPRA","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"PH","regulator":"FDA-PH","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"CO","regulator":"INVIMA","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"ZA","regulator":"SAHPRA","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"TW","regulator":"TFDA","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"HK","regulator":"DH","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"IL","regulator":"MOH","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"SG","regulator":"HSA","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"AE","regulator":"MOH","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"KR","regulator":"MFDS","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"AU","regulator":"TGA","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"GB","regulator":"MHRA","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null}],"trialStats":{"total":0,"withResults":0},"validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T02:02:17.494208+00:00","fieldsConflicting":1,"overallConfidence":0.8},"verificationStatus":"enriching","dataCompleteness":{"mechanism":false,"indications":false,"safety":false,"trials":false,"score":0}}