{"id":"desf","rwe":[{"pmid":"41809631","year":"2026","title":"Multi-trait and multi-environment genomic prediction enhances yield components improvement in durum wheat.","finding":"","journal":"Frontiers in plant science","studyType":"Clinical Study"},{"pmid":"41800140","year":"2026","title":"Genetic differentiation of morphologically similar polyploid wheat species.","finding":"","journal":"PeerJ","studyType":"Clinical Study"},{"pmid":"41794297","year":"2026","title":"Characterization of an NADPH-dependent 17ɑ-hydroxysteroid dehydrogenase encoded by the desF gene from the gut bacterium Clostridium scindens VPI 12708.","finding":"","journal":"The Journal of steroid biochemistry and molecular biology","studyType":"Clinical Study"},{"pmid":"41754228","year":"2026","title":"Understanding the Role of Durum Wheat Thioredoxin h-Type TdTrxh2 in Biotic Stress Tolerance.","finding":"","journal":"Plants (Basel, Switzerland)","studyType":"Clinical Study"},{"pmid":"41752444","year":"2026","title":"A Comparison of the Occurrence of Bioactive Compounds in the Grain of Different Triticum Species.","finding":"","journal":"Molecules (Basel, Switzerland)","studyType":"Clinical Study"}],"tags":[{"label":"Small Molecule","category":"modality"},{"label":"Off-Patent","category":"patent"},{"label":"Generic Available","category":"availability"},{"label":"Active","category":"status"},{"label":"Baxter Hlthcare","category":"company"}],"phase":"marketed","safety":{"commonSideEffects":[{"effect":"Coughing","drugRate":"34%","severity":"common","organSystem":""},{"effect":"Breath holding","drugRate":"30%","severity":"common","organSystem":""},{"effect":"Nausea","drugRate":"27%","severity":"common","organSystem":""},{"effect":"Apnea","drugRate":"15%","severity":"common","organSystem":""},{"effect":"Vomiting","drugRate":"16%","severity":"common","organSystem":""},{"effect":"Laryngospasm","drugRate":"","severity":"common","organSystem":""},{"effect":"Increased secretions","drugRate":"3%","severity":"common","organSystem":""},{"effect":"Oxyhemoglobin desaturation (SpO2 < 90%)","drugRate":"","severity":"common","organSystem":""},{"effect":"Pharyngitis","drugRate":"","severity":"common","organSystem":""},{"effect":"Headache","drugRate":"","severity":"common","organSystem":""},{"effect":"Bradycardia","drugRate":"","severity":"common","organSystem":""},{"effect":"Hypertension","drugRate":"","severity":"common","organSystem":""},{"effect":"Nodal arrhythmia","drugRate":"","severity":"common","organSystem":""},{"effect":"Tachycardia","drugRate":"","severity":"common","organSystem":""},{"effect":"Increased salivation","drugRate":"","severity":"common","organSystem":""},{"effect":"Cough increased","drugRate":"","severity":"common","organSystem":""},{"effect":"Conjunctivitis (conjunctival hyperemia)","drugRate":"","severity":"common","organSystem":""}],"contraindications":["Benign intracranial hypertension","Cirrhosis of liver","Disease of liver","Disorder of coronary artery","Duchenne muscular dystrophy","Familial periodic paralysis","Hyperkalemia","Lesion of brain","Malignant hyperthermia","Myasthenia gravis","Neuromyopathy","Viral hepatitis C","Viral hepatitis type B"],"seriousAdverseEvents":[{"effect":"Hepatic failure","drugRate":"","severity":"serious"},{"effect":"Hepatic necrosis","drugRate":"","severity":"serious"},{"effect":"Respiratory arrest","drugRate":"","severity":"serious"},{"effect":"Respiratory failure","drugRate":"","severity":"serious"},{"effect":"Cardiac arrest","drugRate":"","severity":"serious"},{"effect":"Myocardial infarction","drugRate":"","severity":"serious"},{"effect":"Ventricular failure","drugRate":"","severity":"serious"},{"effect":"Torsade de pointes","drugRate":"","severity":"serious"},{"effect":"Convulsion","drugRate":"","severity":"serious"},{"effect":"Malignant hypertension","drugRate":"","severity":"serious"}]},"trials":[],"aliases":[],"company":"Baxter Hlthcare","patents":[],"pricing":[],"allNames":["desf"],"offLabel":[],"synonyms":[],"timeline":[{"date":"2000-01-01","type":"neutral","source":"FDA Orange Book","milestone":"Rights transferred from Aquestive Therapeutics to Baxter Hlthcare"},{"date":"2018-02-26","type":"neutral","source":"FDA Orange Book","milestone":"Generic entry — 1 manufacturer approved"}],"approvals":[],"ecosystem":[],"mechanism":{"target":"Potassium channel subfamily K member 10, Potassium channel subfamily K member 18, Potassium channel subfamily K member 2","modality":"Small Molecule","explanation":"Imagine desf as a key that fits into a lock on a cell. When it binds to the lock, it triggers a series of events that ultimately lead to the desired outcome, such as reducing symptoms or slowing disease progression.","oneSentence":"Desf works by interacting with a specific biological target to produce a therapeutic effect.","technicalDetail":"Desf is a small molecule that binds to a specific receptor or enzyme, altering its activity and leading to a cascade of downstream effects that result in its therapeutic effects."},"commercial":{},"references":[{"id":1,"url":"https://clinicaltrials.gov/search?intr=desf","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=desf","fields":["publications"],"source":"PubMed/NCBI"},{"id":3,"url":"https://www.fda.gov/drugs/drug-approvals-and-databases/orange-book-data-files","fields":["patents","exclusivity","genericManufacturers"],"source":"FDA Orange Book"}],"_enrichedAt":"2026-03-31T10:29:43.844970","biosimilars":[],"competitors":[],"genericName":"desf","indications":{"approved":[{"name":"General anesthesia","diseaseId":"general-anesthesia","approvalDate":"","lineOfTherapy":"","approvalCountry":"United States"}],"offLabel":[],"pipeline":[]},"currentOwner":"Baxter Hlthcare","drugCategory":"active","labelChanges":[],"patentStatus":"Off-patent — no active Orange Book patents","relatedDrugs":[],"trialDetails":[{"nctId":"NCT06527937","phase":"PHASE2","title":"Pharmacokinetics Study of DESF in Adults With Oral Allergy Syndrome","status":"COMPLETED","sponsor":"Aquestive Therapeutics","startDate":"2024-07-17","conditions":["Allergic Reaction"],"enrollment":36,"completionDate":"2024-10-13"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{},"_patentsChecked":true,"formularyStatus":[],"_enricherVersion":"v2-openfda","developmentCodes":[],"ownershipHistory":[{"period":"","companyName":"Aquestive Therapeutics","relationship":"Original Developer"},{"period":"present","companyName":"Baxter Hlthcare","relationship":"Current Owner"}],"publicationCount":753,"therapeuticAreas":["Other"],"biosimilarFilings":[],"originalDeveloper":"Aquestive Therapeutics","recentPublications":[{"date":"2026","pmid":"41809631","title":"Multi-trait and multi-environment genomic prediction enhances yield components improvement in durum wheat.","journal":"Frontiers in plant science"},{"date":"2026","pmid":"41800140","title":"Genetic differentiation of morphologically similar polyploid wheat species.","journal":"PeerJ"},{"date":"2026 Mar 5","pmid":"41794297","title":"Characterization of an NADPH-dependent 17ɑ-hydroxysteroid dehydrogenase encoded by the desF gene from the gut bacterium Clostridium scindens VPI 12708.","journal":"The Journal of steroid biochemistry and molecular biology"},{"date":"2026 Feb 7","pmid":"41754228","title":"Understanding the Role of Durum Wheat Thioredoxin h-Type TdTrxh2 in Biotic Stress Tolerance.","journal":"Plants (Basel, Switzerland)"},{"date":"2026 Feb 14","pmid":"41752444","title":"A Comparison of the Occurrence of Bioactive Compounds in the Grain of Different Triticum Species.","journal":"Molecules (Basel, Switzerland)"}],"companionDiagnostics":[],"genericManufacturers":1,"_genericFilersChecked":true,"genericManufacturerList":["Shanghai Hengrui"],"status":"active","brandName":"DESF","companyName":"Baxter Hlthcare","companyId":"baxter","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Desf is a small molecule drug developed by Aquestive Therapeutics and currently owned by Baxter Healthcare. Unfortunately, there is limited information available on its target, drug class, and approved indications. It is available as a generic medication, indicating that its patent has expired. As a result, there is no active Orange Book patent for desf. Further research is needed to understand its mechanism of action and key safety considerations.","enrichmentLevel":3,"visitCount":0,"regulatoryByCountry":[{"country_code":"US","regulator":"FDA","status":"approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null}],"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}