{"id":"deserpidine","rwe":[{"pmid":"41552486","year":"2026","title":"PI3K/AKT/eNOS Modulation and Angiotensin II Suppression by Dryopteris crassirhizoma Rhizome Extract: Computational and Experimental Evidence.","finding":"","journal":"ACS omega","studyType":"Clinical Study"},{"pmid":"37759347","year":"2023","title":"Inhibition of extracellular vesicle-derived miR-146a-5p decreases progression of melanoma brain metastasis via Notch pathway dysregulation in astrocytes.","finding":"","journal":"Journal of extracellular vesicles","studyType":"Clinical Study"},{"pmid":"19620026","year":"2009","title":"Liquid chromatography/tandem mass spectrometry method for the quantification of deserpidine in human plasma: Application to a pharmacokinetic study.","finding":"","journal":"Journal of chromatography. B, Analytical technologies in the biomedical and life sciences","studyType":"Clinical Study"},{"pmid":"16309312","year":"2005","title":"Synthesis of deserpidine from reserpine.","finding":"","journal":"Journal of natural products","studyType":"Clinical Study"},{"pmid":"574544","year":"1979","title":"Antibody specificity studies for reserpine, its metabolites, and synthetic reserpine congeners: radioimmunoassay.","finding":"","journal":"Journal of pharmaceutical sciences","studyType":"Clinical Study"}],"tags":[{"label":"Catecholamine-depleting Sympatholytic","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Synaptic vesicular amine transporter","category":"target"},{"label":"SLC18A2","category":"gene"},{"label":"C02AA05","category":"atc"},{"label":"Off-Patent","category":"patent"},{"label":"Active","category":"status"},{"label":"Approved 1950s","category":"decade"}],"phase":"marketed","safety":{"contraindications":["Acute pancreatitis","Anuria","Azotemia","Cirrhosis of liver","Dehydration","Diabetes mellitus","Disease of liver","Fluid volume disorder","Gout","Hepatic coma","Hypercalcemia","Hypercholesterolemia","Hyperparathyroidism","Hypertriglyceridemia","Hyperuricemia","Hypochloremic alkalosis","Hypokalemia","Hypomagnesemia","Hyponatremia","Hypovolemia","Impaired renal function disorder","Neonatal hyperbilirubinemia","Oliguria","Secondary angle-closure glaucoma","Sympathectomy","Systemic lupus erythematosus"]},"trials":[],"aliases":[],"patents":[],"pricing":[],"_sources":{"trials":{"url":"https://clinicaltrials.gov/search?intr=DESERPIDINE","method":"api_direct","source":"ClinicalTrials.gov","rawText":"","confidence":1,"sourceType":"ctgov","retrievedAt":"2026-04-20T00:38:29.584731+00:00"},"regulatory.ca":{"url":"","method":"api_direct","source":"Health Canada DPD","rawText":"","confidence":1,"sourceType":"health_canada_dpd","retrievedAt":"2026-04-20T00:38:35.769204+00:00"},"publicationCount":{"url":"https://pubmed.ncbi.nlm.nih.gov/?term=DESERPIDINE","method":"api_direct","source":"PubMed/NCBI","rawText":"","confidence":1,"sourceType":"pubmed","retrievedAt":"2026-04-20T00:38:36.574181+00:00"},"mechanism.target_chembl":{"url":"","method":"api_direct","source":"ChEMBL mechanism: Synaptic vesicular amine transporter inhibitor","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T00:38:37.618880+00:00"},"crossReferences.chemblId":{"url":"https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL1200515/","method":"api_direct","source":"ChEMBL (EMBL-EBI)","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T00:38:37.275610+00:00"}},"allNames":"raunormin","offLabel":[],"synonyms":["deserpidine","deserpidin","raunormin","raunormine","recanescin","recanescine","reserpidine"],"timeline":[{"date":"1957-04-19","type":"positive","source":"DrugCentral","milestone":"FDA approval"}],"aiSummary":"Raunormin (Deserpidine) is a catecholamine-depleting sympatholytic small molecule originally developed by and currently owned by a pharmaceutical company. It targets the synaptic vesicular amine transporter, leading to a decrease in catecholamine levels in the synaptic cleft. Deserpidine was FDA-approved in 1957 for the treatment of hypertension and angina pectoris. Due to its off-patent status, there are currently no generic manufacturers. Key safety considerations include its potential to cause orthostatic hypotension and other cardiovascular side effects.","approvals":[{"date":"1957-04-19","orphan":false,"company":"","regulator":"FDA"}],"brandName":"Raunormin","ecosystem":[],"mechanism":{"target":"Synaptic vesicular amine transporter","novelty":"Follow-on","targets":[{"gene":"SLC18A2","source":"DrugCentral","target":"Synaptic vesicular amine transporter","protein":"Synaptic vesicular amine transporter"}],"modality":"Small Molecule","drugClass":"Catecholamine-depleting Sympatholytic","explanation":"","oneSentence":"","technicalDetail":"Deserpidine acts as a competitive inhibitor of the synaptic vesicular amine transporter (SVAT), which is responsible for the reuptake of catecholamines into synaptic vesicles. By blocking this transporter, deserpidine decreases the amount of catecholamines available for release into the synaptic cleft, leading to a decrease in sympathetic tone and a subsequent decrease in blood pressure."},"commercial":{"launchDate":"1957","_launchSource":"DrugCentral (FDA 1957-04-19, )"},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/810","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=DESERPIDINE","fields":["publications"],"source":"PubMed/NCBI"},{"id":3,"url":"https://www.fda.gov/drugs/drug-approvals-and-databases/orange-book-data-files","fields":["patents","exclusivity","genericManufacturers"],"source":"FDA Orange Book"}],"_enrichedAt":"2026-03-30T10:28:15.545977","_validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T00:38:38.892985+00:00","fieldsConflicting":1,"overallConfidence":0.8},"biosimilars":[],"competitors":[{"drugName":"rescinnamine","drugSlug":"rescinnamine","fdaApproval":"1956-10-31","genericCount":1,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"reserpine","drugSlug":"reserpine","fdaApproval":"1955-10-12","genericCount":17,"patentStatus":"Off-patent — generic available","relationship":"same-class"}],"dataSources":[{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"genericName":"deserpidine","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"patentStatus":"Off-patent — no active Orange Book patents","relatedDrugs":[{"drugId":"rescinnamine","brandName":"rescinnamine","genericName":"rescinnamine","approvalYear":"1956","relationship":"same-class"},{"drugId":"reserpine","brandName":"reserpine","genericName":"reserpine","approvalYear":"1955","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{},"_patentsChecked":true,"crossReferences":{"NUI":"N0000147037","MMSL":"4544","NDDF":"000642","UNII":"9016E3VB47","VUID":"4018732","CHEBI":"CHEBI:27478","VANDF":"4018732","INN_ID":"656","RXNORM":"62174","UMLSCUI":"C0175158","chemblId":"CHEMBL1200515","ChEMBL_ID":"CHEMBL1200515","KEGG_DRUG":"D08194","DRUGBANK_ID":"DB01089","PUBCHEM_CID":"8550","SNOMEDCT_US":"26503009","IUPHAR_LIGAND_ID":"7064","MESH_SUPPLEMENTAL_RECORD_UI":"C100104"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":49,"therapeuticAreas":["Cardiovascular"],"atcClassification":{"source":"DrugCentral","atcCode":"C02AA05","allCodes":["C02AA05","C02LA03"]},"biosimilarFilings":[],"recentPublications":[{"date":"2026 Jan 13","pmid":"41552486","title":"PI3K/AKT/eNOS Modulation and Angiotensin II Suppression by Dryopteris crassirhizoma Rhizome Extract: Computational and Experimental Evidence.","journal":"ACS omega"},{"date":"2023 Oct","pmid":"37759347","title":"Inhibition of extracellular vesicle-derived miR-146a-5p decreases progression of melanoma brain metastasis via Notch pathway dysregulation in astrocytes.","journal":"Journal of extracellular vesicles"},{"date":"2009 Oct 1","pmid":"19620026","title":"Liquid chromatography/tandem mass spectrometry method for the quantification of deserpidine in human plasma: Application to a pharmacokinetic study.","journal":"Journal of chromatography. 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