{"id":"dermovate-cream","phase":"phase_1","safety":{"boxedWarnings":[],"safetySignals":[],"drugInteractions":[],"commonSideEffects":["Skin atrophy","Burning or stinging at application site","Telangiectasia","Striae","Local hypopigmentation"],"contraindications":["Hypersensitivity to clobetasol propionate or other corticosteroids","Rosacea","Acne vulgaris","Perioral dermatitis","Untreated bacterial, fungal, or viral skin infections"],"specialPopulations":{},"discontinuationRates":[],"seriousAdverseEvents":[]},"status":"active","trials":["NCT01946386"],"aliases":[],"patents":[],"pricing":[],"modality":"Small molecule","timeline":[],"aiSummary":"","brandName":"Dermovate® cream","companyId":"leo-pharma","mechanism":{"target":"Glucocorticoid receptor","novelty":"","modality":"Small molecule","drugClass":"","explanation":"Clobetasol propionate is a highly potent corticosteroid that binds to cytoplasmic glucocorticoid receptors. This complex then translocates to the nucleus where it modulates gene transcription, suppressing the production of inflammatory cytokines, prostaglandins, and leukotrienes, thereby reducing inflammation, itching, and redness in affected skin.","oneSentence":"Clobetasol propionate binds to glucocorticoid receptors to suppress inflammatory mediators and reduce skin inflammation.","technicalDetail":""},"commercial":null,"_claudeStub":{"ts":1779123398,"model":"claude-sonnet-4-5-20250929"},"companyName":"LEO Pharma","competitors":[{"name":"betamethasone dipropionate","brand":"Diprosone","company":"Organon","rationale":"Potent topical corticosteroid for inflammatory skin conditions"},{"name":"halobetasol propionate","brand":"Ultravate","company":"Sun Pharma","rationale":"Ultra-high potency topical corticosteroid for severe dermatoses"},{"name":"mometasone furoate","brand":"Elocon","company":"Organon","rationale":"Potent topical corticosteroid with favorable safety profile"}],"description":"Dermovate cream is a potent topical corticosteroid containing clobetasol propionate, used to treat severe inflammatory skin conditions. It provides anti-inflammatory, antipruritic, and vasoconstrictive effects for conditions like psoriasis, eczema, and dermatitis that have not responded to less potent steroids.","genericName":"Dermovate® cream","indications":{"approved":[{"status":"approved","condition":"Psoriasis","patientPopulation":"Adults and children over 1 year, short-term treatment"},{"status":"approved","condition":"Eczema","patientPopulation":"Adults and children over 1 year, severe cases"},{"status":"approved","condition":"Lichen planus","patientPopulation":"Adults"},{"status":"approved","condition":"Discoid lupus erythematosus","patientPopulation":"Adults"}],"offLabel":[],"pipeline":[]},"labelChanges":[],"trialDetails":[],"manufacturing":[],"administration":{"icon":"","route":"","frequency":"","formulation":""},"formularyStatus":[],"apiManufacturers":[],"developmentCodes":[],"ownershipHistory":[],"biosimilarFilings":[],"firstApprovalDate":"","companionDiagnostics":[],"firstApprovalCountry":null,"rwe":[],"genericFilers":[],"relatedDrugs":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":false,"score":3}}