{"id":"deptropine","rwe":[{"pmid":"41504784","year":"2026","title":"Integrated bioinformatic identification and translational validation of key biomarkers and therapeutic candidates for preeclampsia-related acute kidney injury.","finding":"","journal":"Archives of gynecology and obstetrics","studyType":"Clinical Study"},{"pmid":"40430433","year":"2025","title":"Systems Biology-Driven Discovery of Host-Targeted Therapeutics for Oropouche Virus: Integrating Network Pharmacology, Molecular Docking, and Drug Repurposing.","finding":"","journal":"Pharmaceuticals (Basel, Switzerland)","studyType":"Clinical Study"},{"pmid":"33381243","year":"2020","title":"Identification of miRNAs as the Crosstalk in the Interaction between Neural Stem/Progenitor Cells and Endothelial Cells.","finding":"","journal":"Disease markers","studyType":"Clinical Study"},{"pmid":"32570749","year":"2020","title":"The Antihistamine Deptropine Induces Hepatoma Cell Death through Blocking Autophagosome-Lysosome Fusion.","finding":"","journal":"Cancers","studyType":"Clinical Study"},{"pmid":"31503425","year":"2019","title":"Integrated transcriptomics reveals master regulators of lung adenocarcinoma and novel repositioning of drug candidates.","finding":"","journal":"Cancer medicine","studyType":"Clinical Study"}],"tags":[{"label":"deptropine","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"R06AX16","category":"atc"},{"label":"Active","category":"status"},{"label":"Histamine Agents","category":"pharmacology"},{"label":"Histamine Antagonists","category":"pharmacology"},{"label":"Histamine H1 Antagonists","category":"pharmacology"},{"label":"Neurotransmitter Agents","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"dibenzheptropine","offLabel":[],"synonyms":["deptropine","dibenzheptropine","deptropine citrate"],"timeline":[],"approvals":[],"brandName":"Dibenzheptropine","ecosystem":[],"mechanism":{"target":"Acetylcholine-binding protein, Soluble acetylcholine receptor","modality":"Small Molecule","drugClass":"deptropine","explanation":"Imagine your body's cells have locks on them, and each lock has a specific key that fits perfectly. Dibenzheptropine is like a key that tries to fit into one of these locks, but we don't know which lock it's meant for or how well it fits.","oneSentence":"Dibenzheptropine is thought to work by interacting with a specific molecular target, but the exact details of this interaction are not well understood.","technicalDetail":"Dibenzheptropine is a small molecule that binds to a specific protein or receptor, potentially altering its function or activity, but the precise molecular details of this interaction are unknown."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/808","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=DEPTROPINE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T10:28:02.125521","biosimilars":[],"competitors":[{"drugName":"cyproheptadine","drugSlug":"cyproheptadine","fdaApproval":"1961-10-17","genericCount":31,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"antazoline","drugSlug":"antazoline","fdaApproval":"1990-04-30","relationship":"same-class"},{"drugName":"triprolidine","drugSlug":"triprolidine","fdaApproval":"1983-05-17","genericCount":6,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"azatadine","drugSlug":"azatadine","fdaApproval":"1977-03-29","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"astemizole","drugSlug":"astemizole","fdaApproval":"1988-12-31","relationship":"same-class"},{"drugName":"terfenadine","drugSlug":"terfenadine","fdaApproval":"","relationship":"same-class"},{"drugName":"loratadine","drugSlug":"loratadine","fdaApproval":"1993-04-12","genericCount":29,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"ketotifen","drugSlug":"ketotifen","fdaApproval":"1999-07-02","patentExpiry":"Mar 27, 2028","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"acrivastine","drugSlug":"acrivastine","fdaApproval":"1994-03-25","relationship":"same-class"},{"drugName":"azelastine","drugSlug":"azelastine","fdaApproval":"1996-11-01","patentExpiry":"Jun 4, 2028","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"epinastine","drugSlug":"epinastine","fdaApproval":"2003-10-16","genericCount":6,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"fexofenadine","drugSlug":"fexofenadine","fdaApproval":"1996-07-25","patentExpiry":"Aug 2, 2030","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"desloratadine","drugSlug":"desloratadine","fdaApproval":"2001-12-21","genericCount":10,"patentStatus":"Off-patent — generic available","relationship":"same-class"}],"dataSources":[{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"genericName":"deptropine","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"cyproheptadine","brandName":"cyproheptadine","genericName":"cyproheptadine","approvalYear":"1961","relationship":"same-class"},{"drugId":"antazoline","brandName":"antazoline","genericName":"antazoline","approvalYear":"1990","relationship":"same-class"},{"drugId":"triprolidine","brandName":"triprolidine","genericName":"triprolidine","approvalYear":"1983","relationship":"same-class"},{"drugId":"azatadine","brandName":"azatadine","genericName":"azatadine","approvalYear":"1977","relationship":"same-class"},{"drugId":"astemizole","brandName":"astemizole","genericName":"astemizole","approvalYear":"1988","relationship":"same-class"},{"drugId":"terfenadine","brandName":"terfenadine","genericName":"terfenadine","approvalYear":"","relationship":"same-class"},{"drugId":"loratadine","brandName":"loratadine","genericName":"loratadine","approvalYear":"1993","relationship":"same-class"},{"drugId":"ketotifen","brandName":"ketotifen","genericName":"ketotifen","approvalYear":"1999","relationship":"same-class"},{"drugId":"acrivastine","brandName":"acrivastine","genericName":"acrivastine","approvalYear":"1994","relationship":"same-class"},{"drugId":"azelastine","brandName":"azelastine","genericName":"azelastine","approvalYear":"1996","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{},"crossReferences":{"UNII":"AY31301GKG","CHEBI":"CHEBI:50189","INN_ID":"1331","UMLSCUI":"C0057763","ChEMBL_ID":"CHEMBL1946186","KEGG_DRUG":"D07404","DRUGBANK_ID":"DB13466","PUBCHEM_CID":"203911","SECONDARY_CAS_RN":"2169-75-7","MESH_SUPPLEMENTAL_RECORD_UI":"C100220"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":38,"therapeuticAreas":["Other"],"atcClassification":{"source":"DrugCentral","atcCode":"R06AX16","allCodes":["R06AX16"]},"biosimilarFilings":[],"recentPublications":[{"date":"2026 Jan 8","pmid":"41504784","title":"Integrated bioinformatic identification and translational validation of key biomarkers and therapeutic candidates for preeclampsia-related acute kidney injury.","journal":"Archives of gynecology and obstetrics"},{"date":"2025 Apr 23","pmid":"40430433","title":"Systems Biology-Driven Discovery of Host-Targeted Therapeutics for Oropouche Virus: Integrating Network Pharmacology, Molecular Docking, and Drug Repurposing.","journal":"Pharmaceuticals (Basel, Switzerland)"},{"date":"2020","pmid":"33381243","title":"Identification of miRNAs as the Crosstalk in the Interaction between Neural Stem/Progenitor Cells and Endothelial Cells.","journal":"Disease markers"},{"date":"2020 Jun 18","pmid":"32570749","title":"The Antihistamine Deptropine Induces Hepatoma Cell Death through Blocking Autophagosome-Lysosome Fusion.","journal":"Cancers"},{"date":"2019 Nov","pmid":"31503425","title":"Integrated transcriptomics reveals master regulators of lung adenocarcinoma and novel repositioning of drug candidates.","journal":"Cancer medicine"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Dibenzheptropine (DEPTROPINE) is a small molecule drug in the deptropine class, but its target and mechanism of action are unknown. Its commercial status and approved indications are also unclear. As a result, there is limited information available on its safety profile, pharmacokinetics, and generic availability. Further research is needed to fully understand this compound. Its development history is also unclear.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}