{"id":"depo-provera-contraceptive-injection-dp150ci","safety":{"commonSideEffects":[{"rate":"30-50","effect":"Irregular bleeding or amenorrhea"},{"rate":"2-3","effect":"Weight gain"},{"rate":"5-10","effect":"Headache"},{"rate":"5-10","effect":"Breast tenderness"},{"rate":"5-10","effect":"Abdominal pain or bloating"},{"rate":null,"effect":"Delayed return to fertility"}]},"_chembl":{"chemblId":"CHEMBL2108760","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Medroxyprogesterone acetate (MPA) is a synthetic progestin that acts on the hypothalamic-pituitary-ovarian axis to inhibit the LH surge required for ovulation. It also alters the endometrium and increases cervical mucus viscosity, creating multiple barriers to conception. The injection provides sustained contraceptive effect for approximately 12 weeks per dose.","oneSentence":"Depo-Provera is a progestin injection that prevents pregnancy by suppressing ovulation and thickening cervical mucus.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:32:17.595Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Contraception in women of reproductive age"}]},"trialDetails":[{"nctId":"NCT00139685","phase":"PHASE4","title":"Depo-Provera: Bone Mineral Density and Total Body Calcium in Adolescent DP150CI Users and Non-Hormonal Contraception","status":"COMPLETED","sponsor":"Pfizer","startDate":"1998-04","conditions":"Contraception, Bone Density","enrollment":350}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Depo-Provera Contraceptive Injection - DP150CI","genericName":"Depo-Provera Contraceptive Injection - DP150CI","companyName":"Pfizer","companyId":"pfizer","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Depo-Provera is a progestin injection that prevents pregnancy by suppressing ovulation and thickening cervical mucus. Used for Contraception in women of reproductive age.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}