{"id":"denopamine","rwe":[{"pmid":"40201403","year":"2025","title":"Drug challenge test for early symptom control in patients with coronary artery spasm: a case report.","finding":"","journal":"European heart journal. Case reports","studyType":"Clinical Study"},{"pmid":"39483406","year":"2024","title":"Successful treatment of vasospastic angina refractory to various therapies using stenting: A case report.","finding":"","journal":"Journal of cardiology cases","studyType":"Clinical Study"},{"pmid":"38648720","year":"2024","title":"Synthesis of Chiral 1,2-Amino Alcohol-Containing Compounds Utilizing Ruthenium-Catalyzed Asymmetric Transfer Hydrogenation of Unprotected α-Ketoamines.","finding":"","journal":"The Journal of organic chemistry","studyType":"Clinical Study"},{"pmid":"37955124","year":"2024","title":"Modulation of fast sodium current in airway smooth muscle cells by exchange protein directly activated by cAMP.","finding":"","journal":"American journal of physiology. Cell physiology","studyType":"Clinical Study"},{"pmid":"36594387","year":"2022","title":"[β-arrestin2 recruitment by β-adrenergic receptor agonists and antagonists].","finding":"","journal":"Sheng li xue bao : [Acta physiologica Sinica]","studyType":"Clinical Study"}],"tags":[{"label":"denopamine","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Beta-1 adrenergic receptor","category":"target"},{"label":"ADRB1","category":"gene"},{"label":"SLC22A1","category":"gene"},{"label":"Active","category":"status"},{"label":"Adrenergic Agents","category":"pharmacology"},{"label":"Adrenergic Agonists","category":"pharmacology"},{"label":"Adrenergic beta-Agonists","category":"pharmacology"},{"label":"Cardiotonic Agents","category":"pharmacology"},{"label":"Cardiovascular Agents","category":"pharmacology"},{"label":"Neurotransmitter Agents","category":"pharmacology"},{"label":"Protective Agents","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"kalgut","offLabel":[],"synonyms":["denopamine","kalgut","carguto"],"timeline":[],"approvals":[],"brandName":"Kalgut","ecosystem":[],"mechanism":{"target":"Solute carrier family 22 member 1, Beta-1 adrenergic receptor","targets":[{"gene":"ADRB1","source":"DrugCentral","target":"Beta-1 adrenergic receptor","protein":"Beta-1 adrenergic receptor"},{"gene":"SLC22A1","source":"DrugCentral","target":"Solute carrier family 22 member 1","protein":"Solute carrier family 22 member 1"}],"modality":"Small Molecule","drugClass":"denopamine","explanation":"Think of it like a key that unlocks a lock on your heart. When denopamine binds to the beta-1 adrenergic receptor, it sends a signal that tells your heart to beat faster and stronger. This can help improve heart function and increase blood flow to the body.","oneSentence":"Denopamine works by stimulating the beta-1 adrenergic receptor, which increases heart rate and contractility.","technicalDetail":"Denopamine acts as a partial agonist at the beta-1 adrenergic receptor, increasing the receptor's activity and leading to increased heart rate and contractility through the activation of adenylate cyclase and subsequent increase in cyclic AMP levels."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/806","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=DENOPAMINE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T10:27:47.627786","biosimilars":[],"competitors":[{"drugName":"alfuzosin","drugSlug":"alfuzosin","fdaApproval":"2003-06-12","genericCount":9,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"amiloride","drugSlug":"amiloride","fdaApproval":"1981-10-05","genericCount":3,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"amitriptyline","drugSlug":"amitriptyline","fdaApproval":"1961-04-07","genericCount":33,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"apomorphine","drugSlug":"apomorphine","fdaApproval":"2004-04-20","patentExpiry":"Jun 11, 2030","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"atropine","drugSlug":"atropine","fdaApproval":"1960-09-15","genericCount":1,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"carvedilol","drugSlug":"carvedilol","fdaApproval":"1995-09-14","genericCount":17,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"chlorhexidine","drugSlug":"chlorhexidine","fdaApproval":"1976-09-17","patentExpiry":"Oct 2, 2027","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"chlorpromazine","drugSlug":"chlorpromazine","fdaApproval":"1957-09-18","patentStatus":"Unknown","relationship":"same-target"},{"drugName":"chlorprothixene","drugSlug":"chlorprothixene","fdaApproval":"1967-06-19","patentStatus":"Unknown","relationship":"same-target"},{"drugName":"citalopram","drugSlug":"citalopram","fdaApproval":"1998-07-17","genericCount":26,"patentStatus":"Off-patent — generic available","relationship":"same-target"}],"dataSources":[{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"genericName":"denopamine","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"alfuzosin","brandName":"alfuzosin","genericName":"alfuzosin","approvalYear":"2003","relationship":"same-target"},{"drugId":"amiloride","brandName":"amiloride","genericName":"amiloride","approvalYear":"1981","relationship":"same-target"},{"drugId":"amitriptyline","brandName":"amitriptyline","genericName":"amitriptyline","approvalYear":"1961","relationship":"same-target"},{"drugId":"apomorphine","brandName":"apomorphine","genericName":"apomorphine","approvalYear":"2004","relationship":"same-target"},{"drugId":"atropine","brandName":"atropine","genericName":"atropine","approvalYear":"1960","relationship":"same-target"},{"drugId":"carvedilol","brandName":"carvedilol","genericName":"carvedilol","approvalYear":"1995","relationship":"same-target"},{"drugId":"chlorhexidine","brandName":"chlorhexidine","genericName":"chlorhexidine","approvalYear":"1976","relationship":"same-target"},{"drugId":"chlorpromazine","brandName":"chlorpromazine","genericName":"chlorpromazine","approvalYear":"1957","relationship":"same-target"},{"drugId":"chlorprothixene","brandName":"chlorprothixene","genericName":"chlorprothixene","approvalYear":"1967","relationship":"same-target"},{"drugId":"citalopram","brandName":"citalopram","genericName":"citalopram","approvalYear":"1998","relationship":"same-target"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{},"crossReferences":{"NDDF":"008205","UNII":"V5F60UPD8P","CHEBI":"CHEBI:135359","INN_ID":"5460","UMLSCUI":"C0075749","ChEMBL_ID":"CHEMBL493682","KEGG_DRUG":"D02614","PUBCHEM_CID":"5311064","IUPHAR_LIGAND_ID":"534","MESH_SUPPLEMENTAL_RECORD_UI":"C037293"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":131,"therapeuticAreas":["Cardiovascular"],"biosimilarFilings":[],"recentPublications":[{"date":"2025 Apr","pmid":"40201403","title":"Drug challenge test for early symptom control in patients with coronary artery spasm: a case report.","journal":"European heart journal. Case reports"},{"date":"2024 Sep","pmid":"39483406","title":"Successful treatment of vasospastic angina refractory to various therapies using stenting: A case report.","journal":"Journal of cardiology cases"},{"date":"2024 May 3","pmid":"38648720","title":"Synthesis of Chiral 1,2-Amino Alcohol-Containing Compounds Utilizing Ruthenium-Catalyzed Asymmetric Transfer Hydrogenation of Unprotected α-Ketoamines.","journal":"The Journal of organic chemistry"},{"date":"2024 Jan 1","pmid":"37955124","title":"Modulation of fast sodium current in airway smooth muscle cells by exchange protein directly activated by cAMP.","journal":"American journal of physiology. Cell physiology"},{"date":"2022 Dec 25","pmid":"36594387","title":"[β-arrestin2 recruitment by β-adrenergic receptor agonists and antagonists].","journal":"Sheng li xue bao : [Acta physiologica Sinica]"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Kalgut, also known as denopamine, is a small molecule drug that targets the beta-1 adrenergic receptor. It is a denopamine drug class, but its commercial status and approved indications are unknown. The mechanism of action involves stimulating the beta-1 adrenergic receptor, which can increase heart rate and contractility. As a result, it may be used to treat heart failure or other cardiovascular conditions. However, its safety and efficacy have not been established through FDA approval.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}