{"id":"dendrobium-huoshanense-suppository","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal irritation"},{"rate":null,"effect":"Local rectal discomfort"},{"rate":null,"effect":"Allergic reaction"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Dendrobium Huoshanense is a traditional Chinese medicinal orchid whose active constituents, including polysaccharides and alkaloid compounds, are believed to stimulate natural killer cells and T-cell mediated immunity while inducing programmed cell death in malignant cells. The suppository formulation allows direct mucosal absorption and systemic distribution of these immunomodulatory and cytotoxic agents.","oneSentence":"Dendrobium Huoshanense extract suppository delivers bioactive polysaccharides and alkaloids that enhance immune function and promote apoptosis in cancer cells.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T01:09:00.126Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Cancer (specific indication not publicly detailed; Phase 3 status suggests advanced solid tumors or hematologic malignancy)"}]},"trialDetails":[{"nctId":"NCT05079438","phase":"PHASE3","title":"Dendrobium Huoshanense Suppository in Rectal Cancer","status":"UNKNOWN","sponsor":"Zhejiang Cancer Hospital","startDate":"2021-09-07","conditions":"Locally Advanced Rectal Cancer","enrollment":168}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Dendrobium Huoshanense Suppository","genericName":"Dendrobium Huoshanense Suppository","companyName":"Zhejiang Cancer Hospital","companyId":"zhejiang-cancer-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Dendrobium Huoshanense Suppository is being studied as a treatment for locally advanced rectal cancer in a multicenter randomized controlled clinical trial. The study, titled \"A Multicenter Randomized Controlled Stage III Clinical Study of Dendrobium Huoshanense Suppository in Locally Advanced Rectal Cancer Patients Treated by Neoadjuvant Chemoradiotherapy,\" is being conducted at the Zhejiang Cancer Hospital.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}