{"id":"demegestone","rwe":[{"pmid":"1751397","year":"1991","title":"In vitro effect of synthetic progestogens on estrone sulfatase activity in human breast carcinoma.","finding":"","journal":"The Journal of steroid biochemistry and molecular biology","studyType":"Clinical Study"},{"pmid":"2345270","year":"1990","title":"[Male pseudo-hermaphroditism. Prenatal factors].","finding":"","journal":"Journal de gynecologie, obstetrique et biologie de la reproduction","studyType":"Clinical Study"},{"pmid":"3194612","year":"1988","title":"[Luteal insufficiency and elevation of sex-binding proteins by demegestone].","finding":"","journal":"Revue francaise de gynecologie et d'obstetrique","studyType":"Clinical Study"}],"tags":[{"label":"demegestone","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"G03DB05","category":"atc"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"lutionex","offLabel":[],"synonyms":["demegestone","lutionex"],"timeline":[],"approvals":[],"brandName":"Lutionex","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"demegestone","explanation":"Think of it like a key fitting into a lock. Demegestone is a key that fits into the progesterone receptor, allowing it to send signals to the body that progesterone is present. This helps to regulate the growth and maintenance of female reproductive tissues.","oneSentence":"Demegestone works by binding to and activating the progesterone receptor, mimicking the effects of the hormone progesterone.","technicalDetail":"Demegestone is a selective progesterone receptor modulator (SPRM) that binds to the progesterone receptor with high affinity, inducing a conformational change that activates the receptor and triggers downstream signaling pathways."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/803","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=DEMEGESTONE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T10:33:12.484192","biosimilars":[],"competitors":[{"drugName":"dydrogesterone","drugSlug":"dydrogesterone","fdaApproval":"","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"megestrol acetate","drugSlug":"megestrol-acetate","fdaApproval":"1971-08-18","genericCount":10,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"dienogest","drugSlug":"dienogest","fdaApproval":"2010-05-06","relationship":"same-class"}],"genericName":"demegestone","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"dydrogesterone","brandName":"dydrogesterone","genericName":"dydrogesterone","approvalYear":"","relationship":"same-class"},{"drugId":"megestrol-acetate","brandName":"megestrol acetate","genericName":"megestrol acetate","approvalYear":"1971","relationship":"same-class"},{"drugId":"dienogest","brandName":"dienogest","genericName":"dienogest","approvalYear":"2010","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"005320","UNII":"6E89AM91SZ","CHEBI":"CHEBI:135339","INN_ID":"2935","RXNORM":"22483","UMLSCUI":"C0057362","ChEMBL_ID":"CHEMBL2104231","KEGG_DRUG":"D07223","DRUGBANK_ID":"DB13857","PUBCHEM_CID":"93057","MESH_SUPPLEMENTAL_RECORD_UI":"C011214"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":3,"therapeuticAreas":["Other"],"atcClassification":{"source":"DrugCentral","atcCode":"G03DB05","allCodes":["G03DB05"]},"biosimilarFilings":[],"recentPublications":[{"date":"1991 Dec","pmid":"1751397","title":"In vitro effect of synthetic progestogens on estrone sulfatase activity in human breast carcinoma.","journal":"The Journal of steroid biochemistry and molecular biology"},{"date":"1990","pmid":"2345270","title":"[Male pseudo-hermaphroditism. Prenatal factors].","journal":"Journal de gynecologie, obstetrique et biologie de la reproduction"},{"date":"1988 Jul-Sep","pmid":"3194612","title":"[Luteal insufficiency and elevation of sex-binding proteins by demegestone].","journal":"Revue francaise de gynecologie et d'obstetrique"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Lutionex is a small molecule modality. It is also known by the synonyms DEMEGESTONA, DEMEGESTONE, DEMEGESTONE, NSC-118189, R 2453, and R-2453.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}