{"id":"demecolcine","rwe":[{"pmid":"40894525","year":"2025","title":"Bioinformatics Analysis Reveals the Oncogenic Role and Therapeutic Potential of lncRNA SNHG25 in Colon Adenocarcinoma.","finding":"","journal":"International journal of genomics","studyType":"Clinical Study"},{"pmid":"40754871","year":"2026","title":"Diagnostic Biomarkers and Targeted Drug Prediction for Acute Kidney Injury: A Computational Approach.","finding":"","journal":"Endocrine, metabolic & immune disorders drug targets","studyType":"Clinical Study"},{"pmid":"38554341","year":"2024","title":"Biodosimetric analysis of head and neck cancer patients undergoing radiotherapy by dicentric chromosome aberration assay.","finding":"","journal":"Journal of cancer research and therapeutics","studyType":"Clinical Study"},{"pmid":"38491315","year":"2024","title":"In vitro anticancer activity of Hirudinaria manillensis methanolic extract and its validation using in silico molecular docking approach.","finding":"","journal":"Medical oncology (Northwood, London, England)","studyType":"Clinical Study"},{"pmid":"36318780","year":"2023","title":"Mitotic index maximization with no effect on radiation-induced dicentric chromosome frequency.","finding":"","journal":"International journal of radiation biology","studyType":"Clinical Study"}],"tags":[{"label":"demecolcine","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"L01CC01","category":"atc"},{"label":"Active","category":"status"},{"label":"Antimitotic Agents","category":"pharmacology"},{"label":"Antineoplastic Agents","category":"pharmacology"},{"label":"Antineoplastic Agents, Phytogenic","category":"pharmacology"},{"label":"Tubulin Modulators","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"colchamine","offLabel":[],"synonyms":["colchamine","demecolcine","deacetylmethylcolchicine","demecolcin","desmecolcine"],"timeline":[],"approvals":[],"brandName":"Colchamine","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"demecolcine","explanation":"Imagine your cells are like a city with roads and buildings. Microtubules are like the roads that help cells move and divide. Colchamine blocks the formation of these roads, which can stop cancer cells from growing and dividing.","oneSentence":"Colchamine works by binding to tubulin, disrupting microtubule formation and function.","technicalDetail":"Colchamine binds to the beta subunit of tubulin, preventing the polymerization of microtubules and disrupting their function, which is essential for cell division and mitosis."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/4375","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=DEMECOLCINE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T10:27:33.667505","biosimilars":[],"competitors":[],"genericName":"demecolcine","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"Z01IVE25KI","CHEBI":"CHEBI:4393","INN_ID":"509","UMLSCUI":"C0011259","ChEMBL_ID":"CHEMBL433632","DRUGBANK_ID":"DB13318","PDB_CHEM_ID":"LON","PUBCHEM_CID":"220401","MESH_DESCRIPTOR_UI":"D003703"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":246,"therapeuticAreas":["Oncology"],"atcClassification":{"source":"DrugCentral","atcCode":"L01CC01","allCodes":["L01CC01"]},"biosimilarFilings":[],"recentPublications":[{"date":"2025","pmid":"40894525","title":"Bioinformatics Analysis Reveals the Oncogenic Role and Therapeutic Potential of lncRNA SNHG25 in Colon Adenocarcinoma.","journal":"International journal of genomics"},{"date":"2026","pmid":"40754871","title":"Diagnostic Biomarkers and Targeted Drug Prediction for Acute Kidney Injury: A Computational Approach.","journal":"Endocrine, metabolic & immune disorders drug targets"},{"date":"2024 Jan 1","pmid":"38554341","title":"Biodosimetric analysis of head and neck cancer patients undergoing radiotherapy by dicentric chromosome aberration assay.","journal":"Journal of cancer research and therapeutics"},{"date":"2024 Mar 15","pmid":"38491315","title":"In vitro anticancer activity of Hirudinaria manillensis methanolic extract and its validation using in silico molecular docking approach.","journal":"Medical oncology (Northwood, London, England)"},{"date":"2023","pmid":"36318780","title":"Mitotic index maximization with no effect on radiation-induced dicentric chromosome frequency.","journal":"International journal of radiation biology"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Colchamine, also known as demecolcine, is a small molecule drug in the demecolcine class. Its original development is attributed to a specific entity, but current ownership information is not available. The exact target of colchamine is unknown, and its commercial status, including FDA approval and off-patent status, is also unclear. Colchamine is used to treat certain conditions, but specific indications are not provided. As a result, key safety considerations and pharmacokinetic properties, such as half-life and bioavailability, are also unknown.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}