{"id":"delorazepam","rwe":[{"pmid":"39452117","year":"2024","title":"Impact of Benzodiazepine Delorazepam on Growth and Behaviour of Artemia salina Nauplii.","finding":"","journal":"Biology","studyType":"Clinical Study"},{"pmid":"38396658","year":"2024","title":"Benzodiazepine Interference with Fertility and Embryo Development: A Preliminary Survey in the Sea Urchin Paracentrotus lividus.","finding":"","journal":"International journal of molecular sciences","studyType":"Clinical Study"},{"pmid":"38069390","year":"2023","title":"Benzodiazepine Delorazepam Induces Locomotory Hyperactivity and Alterations in Pedal Mucus Texture in the Freshwater Gastropod Planorbarius corneus.","finding":"","journal":"International journal of molecular sciences","studyType":"Clinical Study"},{"pmid":"37481049","year":"2023","title":"Structural and functional damage to the retina and skeletal muscle in Xenopus laevis embryos exposed to the commonly used psychotropic benzodiazepine delorazepam.","finding":"","journal":"Environmental toxicology and pharmacology","studyType":"Clinical Study"},{"pmid":"37414173","year":"2023","title":"Water contamination by delorazepam induces epigenetic defects in the embryos of the clawed frog Xenopus laevis.","finding":"","journal":"The Science of the total environment","studyType":"Clinical Study"}],"tags":[{"label":"delorazepam","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"GABA-A receptor alpha-1/beta-2/gamma-2","category":"target"},{"label":"GABRA1","category":"gene"},{"label":"GABRB2","category":"gene"},{"label":"GABRG2","category":"gene"},{"label":"Active","category":"status"},{"label":"Anticonvulsants","category":"pharmacology"},{"label":"Central Nervous System Agents","category":"pharmacology"}],"phase":"phase_2","safety":{"safetySignals":[{"llr":2540.399,"date":"","count":546,"signal":"Sopor","source":"DrugCentral FAERS","actionTaken":"Reported 546 times (LLR=2540)"},{"llr":2109.726,"date":"","count":651,"signal":"Drug abuse","source":"DrugCentral FAERS","actionTaken":"Reported 651 times (LLR=2110)"},{"llr":1206.377,"date":"","count":308,"signal":"Intentional self-injury","source":"DrugCentral FAERS","actionTaken":"Reported 308 times (LLR=1206)"},{"llr":292.594,"date":"","count":143,"signal":"Intentional overdose","source":"DrugCentral FAERS","actionTaken":"Reported 143 times (LLR=293)"},{"llr":253.106,"date":"","count":70,"signal":"Bradyphrenia","source":"DrugCentral FAERS","actionTaken":"Reported 70 times (LLR=253)"},{"llr":243.675,"date":"","count":119,"signal":"Suicide attempt","source":"DrugCentral FAERS","actionTaken":"Reported 119 times (LLR=244)"},{"llr":207.416,"date":"","count":191,"signal":"Toxicity to various agents","source":"DrugCentral FAERS","actionTaken":"Reported 191 times (LLR=207)"},{"llr":149.567,"date":"","count":116,"signal":"Overdose","source":"DrugCentral FAERS","actionTaken":"Reported 116 times (LLR=150)"},{"llr":141.053,"date":"","count":42,"signal":"Bradykinesia","source":"DrugCentral FAERS","actionTaken":"Reported 42 times (LLR=141)"},{"llr":126.875,"date":"","count":79,"signal":"Intentional product misuse","source":"DrugCentral FAERS","actionTaken":"Reported 79 times (LLR=127)"},{"llr":125.614,"date":"","count":47,"signal":"Psychomotor hyperactivity","source":"DrugCentral FAERS","actionTaken":"Reported 47 times (LLR=126)"},{"llr":114.869,"date":"","count":47,"signal":"Poisoning","source":"DrugCentral FAERS","actionTaken":"Reported 47 times (LLR=115)"},{"llr":98.116,"date":"","count":69,"signal":"Coma","source":"DrugCentral FAERS","actionTaken":"Reported 69 times (LLR=98)"},{"llr":96.287,"date":"","count":31,"signal":"Sluggishness","source":"DrugCentral FAERS","actionTaken":"Reported 31 times (LLR=96)"},{"llr":94.762,"date":"","count":115,"signal":"Confusional state","source":"DrugCentral FAERS","actionTaken":"Reported 115 times (LLR=95)"}],"commonSideEffects":[{"effect":"Sopor","drugRate":"LLR 2540","severity":"serious"},{"effect":"Drug abuse","drugRate":"LLR 2110","severity":"serious"},{"effect":"Intentional self-injury","drugRate":"LLR 1206","severity":"serious"},{"effect":"Bradyphrenia","drugRate":"LLR 253","severity":"common"},{"effect":"Suicide attempt","drugRate":"LLR 244","severity":"common"},{"effect":"Toxicity to various agents","drugRate":"LLR 207","severity":"common"},{"effect":"Overdose","drugRate":"LLR 150","severity":"common"},{"effect":"Bradykinesia","drugRate":"LLR 141","severity":"common"},{"effect":"Intentional product misuse","drugRate":"LLR 127","severity":"common"},{"effect":"Psychomotor hyperactivity","drugRate":"LLR 126","severity":"common"},{"effect":"Poisoning","drugRate":"LLR 115","severity":"common"},{"effect":"Coma","drugRate":"LLR 98","severity":"common"},{"effect":"Sluggishness","drugRate":"LLR 96","severity":"common"},{"effect":"Confusional state","drugRate":"LLR 95","severity":"common"}]},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"chlordemethyldiazepam","offLabel":[],"synonyms":["delorazepam","chlordemethyldiazepam","chlordesmethyldiazepam","chlorodesmethyldiazepam"],"timeline":[],"approvals":[],"brandName":"Chlordemethyldiazepam","ecosystem":[],"mechanism":{"target":"GABA-A receptor alpha-1/beta-2/gamma-2, GABA-A receptor; anion channel","targets":[{"gene":"GABRA1","source":"DrugCentral","target":"GABA-A receptor alpha-1/beta-2/gamma-2","protein":"Gamma-aminobutyric acid receptor subunit alpha-1"},{"gene":"GABRB2","source":"DrugCentral","target":"GABA-A receptor alpha-1/beta-2/gamma-2","protein":"Gamma-aminobutyric acid receptor subunit beta-2"},{"gene":"GABRG2","source":"DrugCentral","target":"GABA-A receptor alpha-1/beta-2/gamma-2","protein":"Gamma-aminobutyric acid receptor subunit gamma-2"},{"gene":"GABRA2","source":"DrugCentral","target":"GABA-A receptor; anion channel","protein":"Gamma-aminobutyric acid receptor 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of cars (neurons) moving around. GABA is like a traffic cop that helps slow down the traffic when it gets too busy. Delorazepam helps the traffic cop do its job more effectively, which can help reduce anxiety and promote relaxation.","oneSentence":"Delorazepam works by enhancing the activity of the neurotransmitter GABA, which helps to calm excessive neuronal activity in the brain.","technicalDetail":"Delorazepam acts as a positive allosteric modulator of the GABA-A receptor, specifically enhancing the activity of the alpha-1, beta-2, and gamma-2 subunits, which increases the frequency of chloride channel opening and subsequent hyperpolarization of the neuronal membrane."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/800","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=DELORAZEPAM","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=DELORAZEPAM","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T10:31:22.663869","biosimilars":[],"competitors":[{"drugName":"alprazolam","drugSlug":"alprazolam","fdaApproval":"1981-10-16","genericCount":24,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"amoxapine","drugSlug":"amoxapine","fdaApproval":"1980-09-22","genericCount":3,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"brexanolone","drugSlug":"brexanolone","fdaApproval":"2019-03-19","patentExpiry":"Nov 27, 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It has been studied in combination with Cognitive Behavioral Therapy, individual psychology brief psychotherapy, and olanzapine, but its exact mechanism of action is not specified in the available data.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":false,"safety":true,"trials":true,"score":3}}