{"id":"delmopinol","rwe":[{"pmid":"37916545","year":"2023","title":"Reduced Use of Antibiotics and Nasal Decongestants During Treatment with a Mouthwash Containing Delmopinol.","finding":"","journal":"Oral health & preventive dentistry","studyType":"Clinical Study"},{"pmid":"37019823","year":"2023","title":"Delmopinol hydrochloride inhibits Campylobacter jejuni on skinless poultry meat, stainless steel, and high-density polyethylene food contact surfaces.","finding":"","journal":"Letters in applied microbiology","studyType":"Clinical Study"},{"pmid":"36610994","year":"2023","title":"Development of a Simple Extraction Procedure and an HPLC Method for the Determination of Delmopinol in a Challenging Rubbery Dental Chew.","finding":"","journal":"Journal of AOAC International","studyType":"Clinical Study"},{"pmid":"34894125","year":"2022","title":"Development and Validation of a Stability-Indicating Reversed-Phase Ultra High Pressure Liquid Chromatography Method for Assay of Delmopinol Hydrochloride and Estimation of Its Related Substances in Commercial Bulk Batches.","finding":"","journal":"Journal of chromatographic science","studyType":"Clinical Study"},{"pmid":"34664294","year":"2022","title":"The microbiome of dental and peri-implant subgingival plaque during peri-implant mucositis therapy: A randomized clinical trial.","finding":"","journal":"Journal of clinical periodontology","studyType":"Clinical Study"}],"tags":[{"label":"delmopinol","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"},{"label":"Dental plaque","category":"indication"},{"label":"Cosmetics","category":"pharmacology"},{"label":"Mouthwashes","category":"pharmacology"},{"label":"Surface-Active Agents","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"decapinol","offLabel":[],"synonyms":["delmopinol","decapinol","delmopinol hydrochloride","delmopinol HCl"],"timeline":[],"approvals":[],"brandName":"Decapinol","ecosystem":[{"indication":"Dental plaque","otherDrugs":[],"globalPrevalence":null}],"mechanism":{"modality":"Small Molecule","drugClass":"delmopinol","explanation":"This means that Decapinol creates a barrier on the teeth that prevents bacteria from sticking to them, making it harder for plaque to form. This helps to prevent the development of gum disease and other oral health issues.","oneSentence":"Decapinol works by preventing the adhesion of bacteria to tooth surfaces.","technicalDetail":"Decapinol acts as a non-ionic surfactant that interferes with the hydrophobic interactions between bacterial cells and tooth surfaces, thereby inhibiting bacterial adhesion and biofilm formation."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/3131","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=DELMOPINOL","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=DELMOPINOL","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T10:27:24.317106","biosimilars":[],"competitors":[],"genericName":"delmopinol","indications":{"approved":[{"name":"Dental plaque","source":"DrugCentral","snomedId":4522001,"regulator":"FDA"}],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[{"nctId":"NCT03421145","phase":"","title":"A Clinical Study to Evaluate Effects of an Oral Rinse on Plaque and Gingivitis","status":"COMPLETED","sponsor":"Solventum US LLC","startDate":"2017-12-17","conditions":["Plaque"],"enrollment":200,"completionDate":"2019-01-17"},{"nctId":"NCT01236950","phase":"NA","title":"Study of an Essential Oil and a Delmopinol Mouthrinse Effect on Dental Plaque Accumulation Index, Gingivitis Index and on Streptococcus Mutans, Lactobacillus, Aerobic and Anaerobic Oral Bacteria Colony Counts.","status":"COMPLETED","sponsor":"University of Lisbon","startDate":"2007-04","conditions":["Gingivitis","Dental Plaque Accumulation"],"enrollment":90,"completionDate":"2008-09"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"DT67WL708F","CHEBI":"CHEBI:135122","INN_ID":"5586","RXNORM":"60451","UMLSCUI":"C0166532","ChEMBL_ID":"CHEMBL2104220","PUBCHEM_CID":"57337","SNOMEDCT_US":"416652002","SECONDARY_CAS_RN":"98092-92-3","MESH_SUPPLEMENTAL_RECORD_UI":"C073738"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":70,"therapeuticAreas":["Infectious Disease"],"biosimilarFilings":[],"recentPublications":[{"date":"2023 Nov 2","pmid":"37916545","title":"Reduced Use of Antibiotics and Nasal Decongestants During Treatment with a Mouthwash Containing Delmopinol.","journal":"Oral health & preventive dentistry"},{"date":"2023 Apr 3","pmid":"37019823","title":"Delmopinol hydrochloride inhibits Campylobacter jejuni on skinless poultry meat, stainless steel, and high-density polyethylene food contact surfaces.","journal":"Letters in applied microbiology"},{"date":"2023 May 3","pmid":"36610994","title":"Development of a Simple Extraction Procedure and an HPLC Method for the Determination of Delmopinol in a Challenging Rubbery Dental Chew.","journal":"Journal of AOAC International"},{"date":"2022 Nov 5","pmid":"34894125","title":"Development and Validation of a Stability-Indicating Reversed-Phase Ultra High Pressure Liquid Chromatography Method for Assay of Delmopinol Hydrochloride and Estimation of Its Related Substances in Commercial Bulk Batches.","journal":"Journal of chromatographic science"},{"date":"2022 Jan","pmid":"34664294","title":"The microbiome of dental and peri-implant subgingival plaque during peri-implant mucositis therapy: A randomized clinical trial.","journal":"Journal of clinical periodontology"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Decapinol, also known as delmopinol, is a small molecule drug in the delmopinol class. It is used to treat dental plaque, a condition where bacteria accumulate on teeth. The commercial status of Decapinol is unclear, but it is likely patented. Key safety considerations include unknown half-life and bioavailability. Decapinol is owned by an unknown entity.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":true,"score":3}}