{"id":"delapril","rwe":[{"pmid":"39445993","year":"2024","title":"[The delapril-indapamide combination in treatment of arterial hypertension: practical implications in light of the new guidelines.].","finding":"","journal":"Recenti progressi in medicina","studyType":"Clinical Study"},{"pmid":"37149094","year":"2023","title":"In silico and in vitro screening for carcinogenic potential of angiotensin-converting enzyme inhibitors and their degradation impurities.","finding":"","journal":"Toxicology and applied pharmacology","studyType":"Clinical Study"},{"pmid":"36540585","year":"2022","title":"The Effect of Commonly Used Fixed-Dose Single Pill Combinations of Renin-Angiotensin-System Blockers and Calcium Channel Blockers on HOMA-IR Index in Hypertensive Patients with Impaired Fasting Glucose: a 12-Week Randomized Open-Label Prospective Study.","finding":"","journal":"Maedica","studyType":"Clinical Study"},{"pmid":"32752951","year":"2021","title":"Molecular docking, molecular dynamics simulations and reactivity, studies on approved drugs library targeting ACE2 and SARS-CoV-2 binding with ACE2.","finding":"","journal":"Journal of biomolecular structure & dynamics","studyType":"Clinical Study"},{"pmid":"30965050","year":"2019","title":"Inhibitory effects of antihypertensive drugs on human cytochrome P450 2J2 activity: Potent inhibition by azelnidipine and manidipine.","finding":"","journal":"Chemico-biological interactions","studyType":"Clinical Study"}],"tags":[{"label":"delapril","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Angiotensin-converting enzyme","category":"target"},{"label":"ACE","category":"gene"},{"label":"C09AA12","category":"atc"},{"label":"Active","category":"status"},{"label":"Hypertensive disorder","category":"indication"},{"label":"Angiotensin-Converting Enzyme Inhibitors","category":"pharmacology"},{"label":"Antihypertensive Agents","category":"pharmacology"},{"label":"Cardiovascular Agents","category":"pharmacology"},{"label":"Enzyme Inhibitors","category":"pharmacology"},{"label":"Protease Inhibitors","category":"pharmacology"}],"phase":"phase_3","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"alindapril","offLabel":[],"synonyms":["CV-3317","delapril","alindapril","indalapril"],"timeline":[],"approvals":[],"brandName":"Alindapril","ecosystem":[{"indication":"Hypertensive disorder","otherDrugs":[{"name":"acebutolol","slug":"acebutolol","company":"Promius Pharma"},{"name":"aliskiren","slug":"aliskiren","company":"Novartis"},{"name":"amiloride","slug":"amiloride","company":"Paddock Llc"},{"name":"amlodipine","slug":"amlodipine","company":"Pfizer"}],"globalPrevalence":null}],"mechanism":{"target":"Angiotensin-converting enzyme","targets":[{"gene":"ACE","source":"DrugCentral","target":"Angiotensin-converting enzyme","protein":"Angiotensin-converting enzyme"}],"modality":"Small Molecule","drugClass":"delapril","explanation":"Think of your blood vessels like roads in a city. When the angiotensin-converting enzyme is active, it's like a traffic cop directing more traffic onto the roads, making them narrower and harder to pass through. Delapril blocks this traffic cop, allowing the roads to stay open and blood to flow more easily.","oneSentence":"Delapril works by blocking the action of angiotensin-converting enzyme, a protein that constricts blood vessels.","technicalDetail":"Delapril inhibits the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor, thereby reducing peripheral resistance and lowering blood pressure."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/798","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=DELAPRIL","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=DELAPRIL","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T10:27:11.350884","biosimilars":[],"competitors":[{"drugName":"captopril","drugSlug":"captopril","fdaApproval":"1981-04-06","genericCount":21,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"enalapril","drugSlug":"enalapril","fdaApproval":"1985-12-24","patentExpiry":"Nov 6, 2032","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"lisinopril","drugSlug":"lisinopril","fdaApproval":"1987-12-29","patentExpiry":"Nov 6, 2035","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"perindopril","drugSlug":"perindopril","fdaApproval":"1993-12-30","genericCount":5,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"ramipril","drugSlug":"ramipril","fdaApproval":"1991-01-28","patentExpiry":"Aug 16, 2039","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"quinapril","drugSlug":"quinapril","fdaApproval":"1991-11-19","genericCount":12,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"benazepril","drugSlug":"benazepril","fdaApproval":"1991-06-25","genericCount":12,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"fosinopril","drugSlug":"fosinopril","fdaApproval":"1991-05-16","genericCount":10,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"trandolapril","drugSlug":"trandolapril","fdaApproval":"1996-04-26","genericCount":10,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"spirapril","drugSlug":"spirapril","fdaApproval":"1994-12-29","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"moexipril","drugSlug":"moexipril","fdaApproval":"1995-04-19","genericCount":4,"patentStatus":"Off-patent — generic available","relationship":"same-class"}],"genericName":"delapril","indications":{"approved":[{"name":"Hypertensive disorder","source":"DrugCentral","snomedId":38341003,"regulator":"FDA"}],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"captopril","brandName":"captopril","genericName":"captopril","approvalYear":"1981","relationship":"same-class"},{"drugId":"enalapril","brandName":"enalapril","genericName":"enalapril","approvalYear":"1985","relationship":"same-class"},{"drugId":"lisinopril","brandName":"lisinopril","genericName":"lisinopril","approvalYear":"1987","relationship":"same-class"},{"drugId":"perindopril","brandName":"perindopril","genericName":"perindopril","approvalYear":"1993","relationship":"same-class"},{"drugId":"ramipril","brandName":"ramipril","genericName":"ramipril","approvalYear":"1991","relationship":"same-class"},{"drugId":"quinapril","brandName":"quinapril","genericName":"quinapril","approvalYear":"1991","relationship":"same-class"},{"drugId":"benazepril","brandName":"benazepril","genericName":"benazepril","approvalYear":"1991","relationship":"same-class"},{"drugId":"fosinopril","brandName":"fosinopril","genericName":"fosinopril","approvalYear":"1991","relationship":"same-class"},{"drugId":"trandolapril","brandName":"trandolapril","genericName":"trandolapril","approvalYear":"1996","relationship":"same-class"},{"drugId":"spirapril","brandName":"spirapril","genericName":"spirapril","approvalYear":"1994","relationship":"same-class"}],"trialDetails":[{"nctId":"NCT07262710","phase":"","title":"Association of Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers With Post-Stroke Pneumonia: A Real-World Retrospective Cohort Study","status":"NOT_YET_RECRUITING","sponsor":"First Teaching Hospital of Tianjin University of Traditional Chinese Medicine","startDate":"2025-12-01","conditions":["Post-stroke Pneumonia"],"enrollment":13656,"completionDate":"2026-08-19"},{"nctId":"NCT00157586","phase":"PHASE3","title":"Delapril and Manidipine for Nephroprotection in Diabetes (DEMAND)","status":"COMPLETED","sponsor":"Mario Negri Institute for Pharmacological Research","startDate":"2002-02","conditions":["Type 2 Diabetes"],"enrollment":342,"completionDate":"2008-06"},{"nctId":"NCT00627952","phase":"PHASE3","title":"A Study to Evaluate the Effects of Manidipine Versus Amlodipine and the Combination of Manidipine Plus Delapril Versus Amlodipine Plus Delapril on Intraglomerular Pressure in Hypertensive Patients","status":"COMPLETED","sponsor":"University of Erlangen-Nürnberg Medical School","startDate":"2007-11","conditions":["Hypertension"],"enrollment":100,"completionDate":"2008-12"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"008159","UNII":"W77UAL9THI","CHEBI":"CHEBI:135735","INN_ID":"5797","UMLSCUI":"C0057301","ChEMBL_ID":"CHEMBL589583","DRUGBANK_ID":"DB13312","PUBCHEM_CID":"5362116","SNOMEDCT_US":"698093003","SECONDARY_CAS_RN":"83398-08-7","MESH_SUPPLEMENTAL_RECORD_UI":"C047759"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"pharmacokinetics":{"source":"DrugCentral","bioavailability":"55%"},"publicationCount":145,"therapeuticAreas":["Cardiovascular"],"atcClassification":{"source":"DrugCentral","atcCode":"C09AA12","allCodes":["C09AA12","C09BA12","C09BB12"]},"biosimilarFilings":[],"recentPublications":[{"date":"2024 Oct","pmid":"39445993","title":"[The delapril-indapamide combination in treatment of arterial hypertension: practical implications in light of the new guidelines.].","journal":"Recenti progressi in medicina"},{"date":"2023 Jun 15","pmid":"37149094","title":"In silico and in vitro screening for carcinogenic potential of angiotensin-converting enzyme inhibitors and their degradation impurities.","journal":"Toxicology and applied pharmacology"},{"date":"2022 Sep","pmid":"36540585","title":"The Effect of Commonly Used Fixed-Dose Single Pill Combinations of Renin-Angiotensin-System Blockers and Calcium Channel Blockers on HOMA-IR Index in Hypertensive Patients with Impaired Fasting Glucose: a 12-Week Randomized Open-Label Prospective Study.","journal":"Maedica"},{"date":"2021 Nov","pmid":"32752951","title":"Molecular docking, molecular dynamics simulations and reactivity, studies on approved drugs library targeting ACE2 and SARS-CoV-2 binding with ACE2.","journal":"Journal of biomolecular structure & dynamics"},{"date":"2019 Jun 1","pmid":"30965050","title":"Inhibitory effects of antihypertensive drugs on human cytochrome P450 2J2 activity: Potent inhibition by azelnidipine and manidipine.","journal":"Chemico-biological interactions"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Alindapril, also known as Delapril, is a small molecule drug that targets the angiotensin-converting enzyme (ACE). It belongs to the delapril class and is used to treat hypertensive disorders. The commercial status of Delapril is unclear, but it is likely to be patented or off-patent. Delapril has a bioavailability of 55%, but its half-life and generic manufacturers are unknown. As a result, its FDA approval status and off-patent status are also unclear.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":true,"score":3}}